Iris Parrini

Publications (4)24.26 Total impact

• Article: Management, risk factors, and outcomes in recurrent pericarditis.

  Massimo Imazio, Brunella Demichelis, Iris Parrini, Enrico Cecchi, Daniela Demarie, Aldo Ghisio, Riccardo Belli, Marco Bobbio, Rita Trinchero
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  ABSTRACT: Fifty-five of 294 consecutive patients with acute pericarditis had first attacks of recurrent pericarditis and were evaluated and treated according to a management protocol. Corticosteroids were restricted to aspirin contraindication or failure. Colchicine was added in cases of aspirin and prednisone failure and was the treatment of choice for the second and subsequent recurrences. After logistic regression multivariate analysis, only the previous use of corticosteroids (odds ratio 10.35, 95% confidence interval 4.46 to 23.99, p <0.001) was associated with an increased risk for recurrence. After a mean follow-up of 72 months (range 48 to 108), a similar rate of complications was found in patients with or without recurrences.
  The American Journal of Cardiology 09/2005; 96(5):736-9. · 3.37 Impact Factor
• Article: Relation of acute pericardial disease to malignancy.

  Massimo Imazio, Brunella Demichelis, Iris Parrini, Elisa Favro, Federico Beqaraj, Enrico Cecchi, Franco Pomari, Daniela Demarie, Aldo Ghisio, Riccardo Belli, Marco Bobbio, Rita Trinchero
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  ABSTRACT: Neoplastic etiology was found in 33 of 450 patients with acute pericardial disease (7.3%). Acute pericardial disease was the first manifestation of previously unknown malignancies in 18 of 450 patients (4.0%), and lung cancer was the most common malignancy (72.2%, p = 0.02). The following clinical characteristics were associated with a greater probability of a neoplastic etiology: a history of malignancy (odds ratio [OR] 19.8), cardiac tamponade at presentation (OR 7.0), a lack of response to nonsteroidal anti-inflammatory drugs, and recurrent or incessant pericarditis (OR 10.0). A similar prognosis was found in patients with or without a history of known cancer.
  The American Journal of Cardiology 07/2005; 95(11):1393-4. · 3.37 Impact Factor
• Article: Recurrent pain without objective evidence of disease in patients with previous idiopathic or viral acute pericarditis.

  Massimo Imazio, Brunella Demichelis, Iris Parrini, Enrico Cecchi, Franco Pomari, Daniela Demarie, Gianni Gaschino, Aldo Ghisio, Riccardo Belli, Rita Trinchero
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  ABSTRACT: Recurrent pain without clinical evidence of acute pericarditis was recorded in 27 of 275 patients (9.8%; mean age 55.6 +/- 16.0 years, female/male ratio 20/7) with previous viral or idiopathic acute pericarditis. Female gender (odds ratio [OR] 4.3, 95% confidence interval [CI] 1.8 to 10.6), previous use of corticosteroids (OR 5.2, 95% CI 2.2 to 12.3), and previous recurrent pericarditis (OR 3.7, 95% CI 1.3 to 10.2) were identified as risk factors for this syndrome. After a mean follow-up of 40 months, a higher recurrence rate was recorded in these patients (33.3% vs 14.1%; p = 0.02) as well as a nonsignificant trend to a higher rate of constrictive pericarditis.
  The American Journal of Cardiology 11/2004; 94(7):973-5. · 3.37 Impact Factor
• Article: Day-hospital treatment of acute pericarditis: a management program for outpatient therapy.

  Massimo Imazio, Brunella Demichelis, Iris Parrini, Marco Giuggia, Enrico Cecchi, Gianni Gaschino, Daniela Demarie, Aldo Ghisio, Rita Trinchero
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  ABSTRACT: We sought to investigate the safety and efficacy of a protocol for acute pericarditis triage and outpatient management of low-risk cases. Acute pericarditis has generally a brief and benign course after empiric treatment by non-steroidal anti-inflammatory drugs, and routine hospitalization of most patients may be unnecessary. From January 1996 to December 2001, all consecutive cases of acute pericarditis were evaluated on a day-hospital basis. Patients without clinical poor prognostic predictors (fever >38 degrees C, subacute onset, immunodepression, trauma, oral anticoagulant therapy, myopericarditis, severe pericardial effusion, cardiac tamponade) were considered low-risk cases and assigned to outpatient treatment with high-dose oral aspirin. Patients with poor prognostic predictors or aspirin failure were hospitalized for etiology search and treatment. A clinical and echocardiographic follow-up was performed at 48 to 72 h, 7 to 10 days, 1 month, 6 months, and 1 year. Two hundred fifty-four out of 300 (84.7%) patients were selected as low-risk cases. Outpatient treatment was efficacious in 221 out of 254 (87%) cases. Thirty-three out of 254 patients were hospitalized because of aspirin failure. Patients treated on an out-of-hospital basis had no serious complications after a mean follow-up of 38 months (no cases of cardiac tamponade). A higher frequency of recurrences and constriction was recorded in aspirin-resistant cases than in aspirin responders (60.6% vs. 10.4% for recurrences and 9.1% vs. 0.5% for constriction, respectively; all p < 0.01). A protocol for acute pericarditis triage and outpatient therapy of low-risk cases is safe and efficacious and may reduce management costs.
  Journal of the American College of Cardiology 03/2004; 43(6):1042-6. · 14.16 Impact Factor