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ABSTRACT: OBJECTIVE: To assess the safety and effectiveness of oral propranolol (OP) in the treatment of infantile hemangiomas. MATERIAL AND METHOD: We conducted a prospective study of infantile hemangiomas (IHs) treated with oral propranolol between October 2008 and March 2011. We included fast-growing IHs in the proliferative phase, IHs affecting vital structures, ulcerated IHs, and IHs that could cause functional or aesthetic problems after the proliferative phase. The patients received oral propranolol 2mg/kg/d and were monitored on an outpatient basis. Response to treatment was assessed by volume reduction, lightening of color, improvement of symptoms, and parent satisfaction. Time of initial and peak response, as well as side effects and sequelae, were recorded. RESULTS: We analyzed 20 IHs, corresponding to 17 girls and 3 boys. The main sites of involvement were around the eyes (20%), the nose (15%), the neck (15%), and the trunk (15%). Ninety percent of the hemangiomas were focal and in the proliferative phase. Treatment was started between the ages of 2 and 19 months and the main reason for starting treatment was rapid growth (50% of cases). Initial response was observed in 70% of cases and only in 2 of them it took over a month. Peak response occurred at 3 months. All the IHs responded to treatment; response was excellent in 55% of cases, good in 35%, and minimal in 10%. The following factors were predictive of response: focal IH, proliferative phase, periorbital location, and ulceration. No serious side effects were observed. CONCLUSION: Oral propranolol was clinically effective in reducing the volume and color of infantile hemangiomas, although the reduction was not complete and telangiectasia and scarring persisted after treatment. Oral propranolol also proved to be safe for use in outpatients.
Actas Dermo-Sifiliográficas 06/2012; 103(9):806-815.
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Anales de Pediatría 03/2011; 75(4):277-8. · 0.77 Impact Factor
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ABSTRACT: Many skin diseases appear as annular lesions. Some are more typical of adults or older children, whereas others usually appear in young children. Annular or figurate erythema of infancy comprises a group of dermatoses in which the primary lesion adopts an annular, oval circinate, or polycyclic pattern. Similarities in clinical presentation, age at onset, and duration of lesions mean that these conditions are difficult to diagnose; sometimes, they can only be identified by subtle differences in their clinicopathologic features. Clinical pictures enable us to distinguish one member of this group of diseases from another and also to differentiate them from other annular eruptions. For ease of description, we classify annular erythema of infancy into 2 types: conditions with a known etiology and conditions with characteristic reaction patterns but uncertain etiology.
Actas Dermo-Sifiliográficas 07/2010; 101(6):473-84.
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Actas Dermo-Sifiliográficas 10/2009; 100(7):635-6; author reply 636-7.
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ABSTRACT: The objective of this study was to investigate the possible relationship between the presence of anogenital warts (AGW) in children and the sexual abuse as mode of transmission. Our series includes 8 patients with AGW who were treated in our hospital during the year 2007. A complete physical examination was carried out, including colposcopy or anoscopy, and samples were taken for histopathological examination and human papiloma virus (HPV) subtyping. We considered perinatal transmission as a possible route in two cases. Although sexual abuse was definitively confirmed in only one case, we observed some findings in four cases that led us to consider the possibility of sexual abuse. We did not consider the possibility of heteroinoculation or autoinoculation from common warts in any case. Our results have demonstrated the difficulty in assessing with certainty the source of HPV contamination in children with AGW.
Anales de Pediatría 01/2009; 69(6):572-6. · 0.77 Impact Factor
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Anales de Pediatría 02/2008; 68(1):81-2. · 0.77 Impact Factor
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Anales de Pediatría 10/2007; 67(3):281-2. · 0.77 Impact Factor
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International journal of dermatology 05/2007; 26(4):242 - 243. · 1.18 Impact Factor
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ABSTRACT: Sweat gland origin of Paget disease is demonstrated by the presence of carcinoembryonic antigen (CEA). We studied the expression of CEA and keratin in two cases of extramammary Paget disease. Our results are commented.
Medicina cutánea ibero-latino-americana 02/1989; 17(1):67-9.
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ABSTRACT: Carcinoembryonic antigen (CEA) has been studied extensively, in association with visceral tumors and normal tissues. Although CEA has been demonstrated in sweat gland cutaneous tumors, little is known about its presence in skin and epithelial related tumors. We studied the presence of CEA and keratin in squamous cell and basal cell carcinoma using immunohistochemical techniques. Its distribution related with differentiation, proliferation and malignant potential is observed. The expression of both antigens is correlated.
Medicina cutánea ibero-latino-americana 02/1989; 17(2):121-6.
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ABSTRACT: Carcinoembryonic antigen (CEA) has been studied extensively, in association with visceral tumors and normal tissues. Although CEA has been demonstrated in sweat gland cutaneous tumors, little is known about its presence in skin and epithelial related tumors. We studied the presence of CEA and keratin in keratoacanthomas and precancerous skin lesions using immunohistochemical techniques. Its distribution related with differentiation, proliferation and malignant potential is observed. The expression of both antigens is correlated.
Medicina cutánea ibero-latino-americana 02/1989; 17(2):127-32.
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ABSTRACT: Kawasaki syndrome is not usual in our country. We report this case to stress the clinical importance of this syndrome in which dermatological signs predominate.
Medicina cutánea ibero-latino-americana 02/1988; 16(3):211-2.
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International Journal of Dermatology 06/1987; 26(4):242-3. · 1.14 Impact Factor
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ABSTRACT: We report herein a case of Acquired Immunodeficiency Syndrome in a 38 years old man with Kaposi's sarcoma, which evolution was fulminant in some months. The clinical, pathological and pathogenic characteristics of Kaposi's sarcoma in this syndrome are discussed.
Medicina cutánea ibero-latino-americana 02/1987; 15(2):98-104.
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ABSTRACT: Eosinophilic fasciitis is a syndrome of imprecise classification which usually responds well to corticosteroids. We report a patient who did not respond to such treatment but he improved with cimetidine therapy. The pathogenesis of this syndrome and the possible action mechanism of cimetidine are discussed.
Medicina cutánea ibero-latino-americana 02/1987; 15(1):81-3.
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Annales de Dermatologie et de Vénéréologie 02/1985; 112(10):825-9. · 0.72 Impact Factor