Hiroyoshi Yoshinami

Saitama Medical University, Saitama, Saitama, Japan

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Publications (7)11.48 Total impact

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    ABSTRACT: Background Upper respiratory illness can adversely impact the lower airway. This study aimed to evaluate the relationship between clinical background and improvement in the lower airway after surgery for treatment of chronic rhinosinusitis. Methods A total of 22 patients with chronic rhinosinusitis surgically treated between January 2010 and February 2011 were included in the study. The presence or absence of asthma and peripheral blood eosinophils count were examined for all patients in addition to preoperative radioallergosorbent tests. Spirometry was conducted and fractional exhaled nitric oxide (NO) was measured at the preoperative, 1-month postoperative, and 3-month postoperative visits. Results The average level of NO in the exhaled air at the preoperative, 1-month postoperative, and 3-month postoperative visits was 51.5 ppb, 42.5 ppb, and 38.0 ppb, respectively. Although the average results of spirometry didn't show any improvement, forced expiratory volume in 1 second percentage improved in 2 of 4 cases with obstructive ventilatory disturbance. There were 10 improved cases, which were defined as those showing more than 1.2-fold difference in the ratio of preoperative NO level to the 3-month postoperative one. The remaining 12 cases, including 4 of 6 cases with asthma, 5 of 7cases with eosinophilia, and 4 of 4 cases with animal dander allergy were unimproved cases. Conclusions Chronic rhinosinusitis can cause latent lower respiratory disease. Endoscopic sinus surgery can improve the status of the lower airway. However, the effectiveness of surgery is significantly less in cases of animal dander allergy.
    World Allergy Organization Journal 02/2012; 5(Suppl 2):S95-S95. DOI:10.1097/01.WOX.0000411995.15620.0b
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    Masanobu Shinogami · Ryoji Kagoya · Wakako Nakanishi · Hiroyoshi Yoshinami
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    ABSTRACT: Background Seasonal allergic rhinitis could predispose to the development of chronic bronchial inflammation. However, association between seasonal allergic rhinitis and airway function, especially exhaled nitric oxide [FENO], are not fully understood. Objectives The aim of this study was to evaluate the relationship among FENO and airway function and nasal symptoms in patients with seasonal allergic rhinitis without asthma. Methods We included 37 subjects [9 males and 28 females] in this study. Total serum IgE were investigated and specific IgE for 4 pollen allergens and 5 perennial antigens were determined by RAST. Sensitization to a specific allergen was defined as over RAST score 2. We compared 4 groups. Group A: 7 nonatopic subjects [no nasal symptoms and RIST, RAST negative, 1 males and 6 females, mean age: 33.2 24–52 years]. Group B: 10 atopic subjects with a sensitization to Japanese ceder without medication [6 males and 4 females, mean age: 44 20–58 years]. Group C: 10 atopic subjects with a sensitization to Japanese ceder who took oral anti-histamine medicine during pollen season [2 males and 8 females, mean age: 34.9 24–52 years]. Group D: 10 atopic subjects with a sensitization to Japanese ceder who receive intranasal corticosteroid treatment during pollen season [2 males and 8 females, mean age: 40.2 26–56 years]. Score of nasal symptoms, FENO, spirometry, total eosinophils, nasal eosinophils, were investigated before, during, and after pollen season. Results Regardless of having treatment or not, in comparison with the subjects without the allergy, FENO showed a statistically significant increase in all patients with a sensitization to Japanese after pollen season. In group D, v 50/v 25 was the tendency to adversely affect after the pollen season, and correlation between FeNO rate of the change and v 50/v25 rate of the change admitted. As for the other indexes, a statistically change were not showed in the comparison of each group. Conclusions These results suggest that FENO is a primarily marker of bronchial inflammation in patients with seasonal allergic rhinitis during pollen season and intranasal corticosteroid treatment may be effective for improvements in lower airway outcome.
    World Allergy Organization Journal 02/2012; 5(Suppl 2):S11. DOI:10.1097/01.WOX.0000411778.82590.a0
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    ABSTRACT: Background It is said that the chronic rhinosinusitis influences the lower respiratory airway and there is a report that a tendency to increase the eosinophilic rhinosinusitis later, but they are still unknown. Methods We divided the chronic rhinosinusitis patients with the adaptation of the operation into 4 groups and exaed whether there was a difference in the respiratory function, exhaled NO, and the number of the blood eosinophil. Object 29 patients with chronic rhinosinusitis who planned the endonasal sinus surgery. Results Comparing these 4 groups, it was the worst on the respiratory function (one second rate) in the group with nasal polyps and without nasal allergy. It was recognized the connection between the respiratory function and the presence of the nasal polyps. It was possible that the exhaled NO became the index to the lower airway inflammation. Conclusions We classified the chronic rhinosinusitis and evaluated the lower airway function. It helps the pathologic understanding of the chronic rhinosinusitis. And it leads to understand of the influence on the lower airway inflammation.
    World Allergy Organization Journal 02/2012; 5(Suppl 2):S79. DOI:10.1097/01.WOX.0000411999.07996.b8
  • R. Kagoya · M. Shinogami · H. Mouri · S. Suzuki · W. Nakanishi · H. Yoshinami
    Journal of Allergy and Clinical Immunology 02/2012; 129(2):AB44. DOI:10.1016/j.jaci.2011.12.829 · 11.48 Impact Factor
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    ABSTRACT: We report three cases of hyper-IgG4 disease with synchronous or asynchronous lymphocytic infiltration onset, IgG4 positive plasma cell infiltration, and fibril formation in multiple exocrine glands and extranodal organs. IgG4-related sialadenitis attracting recent attention has yet to be clarified as a clinical entity. Case 1, a 61-year-old man, had a submandibular gland sample showing IgG4-positive plasma cell infiltration. Case 2, a 61-year-old man, was diagnosed with IgG4-related Mikulicz's disease confirmed by a sublingual gland sample. Case 3, a 57-year-old woman, had a diagnosis of IgG4-related Mikulicz's disease confirmed based on labial and sublingual gland samples. All reported oral dryness and bilateral submandibular swelling. Cases 1 and 2 recovered following Predonine administration tapered from 30 or 20 mg. IgG4-related Mikulicz's disease must be recognized as a clinical entity, together with its diagnostic criteria and treatment. Sublingual gland biopsy should be done to confirm its diagnosis following sublingual gland swelling.
    Nippon Jibiinkoka Gakkai Kaiho 10/2010; 113(10):798-804. DOI:10.3950/jibiinkoka.113.798
  • Yasuhiro Kase · Hiroyoshi Yoshinami · Yasuo Toriyama · Hiroto Nakada · Yoshiki Okasaka
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    ABSTRACT: The different modalities of malignant tumor invasion were presented and discussed. When determining the extent of malignant tumor invasion, it is useful to assess surrounding tissues such as bone marrow, fat tissues, and nerves.In addition, qualitative diagnoses can be made based on such information as the location of bony destruction as well as the preservation of maxillary sinus mucosa. We reviewed diseases having characteristic magnetic resonance imaging (MRI) findings.These findings are useful for distinguishing between malignant and benign lesions that occur in the nasal and paranasal sinuses.
    International Congress Series 10/2003; 1240(1240):469-474. DOI:10.1016/S0531-5131(03)00755-6
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    ABSTRACT: The nasal valve area has long been under investigation and has been measured with various methods with varying modifications. This diversity in methodology points to two aspects, namely, the definition itself is vague and the morphological configuration is rather complicated for refined evaluations. We investigated and evaluated the area using coronal CT scans on 133 subjects.
    International Congress Series 10/2003; 1240:1491-1494. DOI:10.1016/S0531-5131(03)00815-X