Publications (2)6.72 Total impact
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Article: Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria.
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ABSTRACT: Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.Infection and Immunity 08/2003; 71(7):4193-6. · 4.16 Impact Factor -
Article: A sub-family of common and highly conserved Plasmodium falciparum var genes.
Molecular and Biochemical Parasitology 07/2002; 122(1):111-5. · 2.55 Impact Factor