Gholam Reza Karimi

Mashhad University of Medical Sciences, Mashad, Razavi Khorasan, Iran

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Publications (1)1.84 Total impact

  • Source
    Hossein Hosseinzadeh · Gholam Reza Karimi · Maryam Ameri ·
    [Show abstract] [Hide abstract]
    ABSTRACT: As a folk remedy, Anethum graveolens seed (dill) is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum graveolens in mice. Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g/kg, i.p., (1.5, 6.16) and 6.98 g/kg, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts. The results suggest that A. graveolens seed extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice.
    BMC Pharmacology 01/2003; 2(1):21. DOI:10.1186/1471-2210-2-21 · 1.84 Impact Factor

Publication Stats

42 Citations
1.84 Total Impact Points

Top Journals


  • 2003
    • Mashhad University of Medical Sciences
      • Department of Pharmacodynamics & Toxicology
      Mashad, Razavi Khorasan, Iran