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ABSTRACT: Chemotherapeutic agents are the primary treatment of many solid (breast, bone, brain, and lung) and hematological malignancies (leukemia, lymphoma, and multiple myeloma). Because these drugs are not specific for cancer cells, healthy, rapidly dividing cells can also be damaged by chemotherapeutic agents, and such damage manifests itself in the form of chemotherapy short- and long-term adverse effects. The increased survival rate for patients with cancer has led to the recognition that adverse effects associated with chemotherapy regimens may appear or persist months to years after chemotherapy has been completed. Therefore, the purpose of this article is to highlight the late adverse effects of the most common chemotherapeutic agents, present screening tools that can suggest the presence of these adverse effects, and then briefly describe rehabilitation considerations with case study examples.
Topics in Geriatric Rehabilitation 06/2011; 27(3):234–243. · 0.14 Impact Factor
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Meredith A Wampler,
Mary Lou Galantino,
Sujuan Huang,
Laura S Gilchrist,
Victoria G Marchese, G Stephen Morris,
David A Scalzitti,
Melissa M Hudson,
Kevin C Oeffinger,
Marilyn Stovall,
Wendy M Leisenring,
Gregory T Armstrong,
Leslie L Robison,
Kirsten K Ness
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ABSTRACT: Adult survivors of childhood lower-extremity sarcoma are largely physically inactive, a behavior which potentially compounds their health burden. Altering this behavior requires understanding those factors that contribute to their physical inactivity. Therefore, this investigation sought to identify factors associated with inactivity in this subpopulation of cancer survivors.
Demographic, personal, treatment, and physical activity information from adult survivors of childhood lower-extremity sarcomas was obtained from the Childhood Cancer Survivor Study (CCSS) cohort. Generalized linear models were used to identify variables that best identified those individuals who were physically inactive.
Only 41% of survivors met Center for Disease Control (CDC) activity guidelines. Survivors were 1.20 (95% confidence intervals (CI) 1.11-1.30) more likely compared to CCSS sibling cohort and 1.12 (95% CI 1.10-1.15) times more likely than the general population to fail to meet CDC guidelines. Significant predictors of physical inactivity included female sex, hemipelvectomy surgery, and platinum and vinca alkaloid chemotherapy.
The primary findings of this study are that survivors of childhood onset lower-extremity sarcoma are (1) highly likely to be physically inactive and (2) less likely than their siblings or the general population to regularly exercise. This study has identified treatment-related risk factors associated with inactivity that will help health and wellness practitioners develop successful exercise interventions to help these survivors achieve recommended levels of physical activity for health.
These results suggest that physical activity interventions for adult survivors of childhood lower-extremity sarcomas should be sex specific and responsive to unique physical late effects experienced by these survivors.
Journal of Cancer Survivorship 06/2011; 6(1):45-53. · 2.63 Impact Factor
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ABSTRACT: Although the incidence of cancer in the United States is high, improvements in early diagnosis and treatment have significantly increased survival rates in recent years. Many survivors of cancer experience lasting, adverse effects caused by either their disease or its treatment. Physical therapy interventions, both established and new, often can reverse or ameliorate the impairments (body function and structure) found in these patients, improving their ability to carry out daily tasks and actions (activity) and to participate in life situations (participation). Measuring the efficacy of physical therapy interventions in each of these dimensions is challenging but essential for developing and delivering optimal care for these patients. This article describes the acute and long-term effects of cancer and its treatment and the use of the World Health Organization's International Classification of Functioning, Disability and Health (ICF) as a basis for selection of assessment or outcome tools and diagnostic or screening tools in this population.
Physical Therapy 02/2009; 89(3):286-306. · 3.11 Impact Factor
