G Pliagus

Publications (2)1.05 Total impact

• Article: Myocardial and circulatory performance during the ischemic phase of superior mesenteric artery occlusion.

  W G Jamieson, G DeRose, K A Harris, G Pliagus, L Stafford
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  ABSTRACT: To investigate myocardial and circulatory parameters during the acute ischemic phase of mesenteric artery occlusion. A prospective, randomized, control trial. Twelve, adult, mongrel dogs. In seven dogs the superior mesenteric artery was occluded with two silk ligatures (experimental group). In five dogs the ligatures were not tied (control group). Measurements were made during 7 hours of occlusion. Myocardial performance and circulatory performance. There were significant (p < 0.05) reductions in arterial blood pressure, mean pulmonary artery pressure, diastolic pulmonary artery pressure and cardiac index in dogs exposed to intestinal ischemia compared with the control dogs. No differences were identified in ventricular performance, stroke volume index or peripheral vascular resistance index. Early cardiac and central circulatory changes in massive intestinal ischemia are due to intravascular hypovolemia. Sepsis and myocardial depressant factors were not found to be a cause of death.
  Canadian journal of surgery. Journal canadien de chirurgie 10/1993; 36(5):435-9. · 1.05 Impact Factor
• Article: Effect of antibiotic and fluid resuscitation upon survival time in experimental intestinal ischemia.

  W G Jamieson, G Pliagus, S Marchuk, G DeRose, D Moffat, L Stafford, R J Finley, W Sibbald, B M Taylor, J Duff
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  ABSTRACT: Acute massive intestinal ischemia is an abdominal catastrophe. Prompt diagnosis and restoration of blood flow is essential; otherwise, massive intestinal resection occurs, leading to death or, in the survivors, intestinal cripples. In this study, the time of warm reversible ischemia in the canine intestine was explored. After this time was established, fluids and antibiotics were administered to note change in survival times. Massive intestinal ischemia (superior mesenteric artery was clamped) was tolerated without death for five hours (20 dogs in each group). With six hours of ischemia, a 10 per cent mortality rate occurred; with seven hours of ischemia, a 90 per cent mortality rate occurred. These dogs had a maintenance of 75 milliliters of fluid administered per hour. Using this group of dogs as the control (that is, the group with seven hour clamping time of the superior mesenteric artery with maintenance intravenously administered replacement), fluids were given to dogs in the experimental group to keep the pulmonary artery wedge pressure at a normal value (average of 300 milliliters per hour). This group of dogs had an increased survival rate of 40 per cent (ten dogs). Antibiotics were given to the dogs in the experimental group both before and after clamping, increasing the over-all survival rate to more than 80 per cent (46 dogs). Aggressive fluid replacement and antibiotic coverage may lengthen the so-called golden period in which intestinal ischemia may be reversed by revascularization.
  Surgery, gynecology & obstetrics 09/1988; 167(2):103-8.