G Ceña Lázaro

Publications (7)8.66 Total impact

• Article: Refractory ulcerative chronic pouchitis in a patient with Gardner syndrome following restorative proctocolectomy with ileal pouch-anal anastomosis.

  Juan J Sebastián-Domingo, Mara Charro-Calvillo, Mónica Navarro-Dourdi, Tomás Cabrera-Chaves, Gloria Ceña-Lázaro, María Ortiz-Lucas
  Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 11/2011; 103(11):600-1. · 1.55 Impact Factor
• Article: [Effects of blood volume expansion on atrial natriuretic factor and the renin-aldosterone axis in experimental cirrhosis].

  J J Sebastián Domingo, F Barrao Comps, F Esteva Díaz, G Ceña Lázaro, M Arroyo, T Serrano
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  ABSTRACT: Serum concentrations of ANF, Renin and Aldosterone were measured in animals with experimental cirrhosis and volume overload. We studied 75 Wistar rats divided in five groups. Group I: rats with hepatic cirrhosis induced by CCl4; Group II: Control rats; Group III: rats with hepatic cirrhosis and continuous infusion of saline serum; Group IV: control rats with continuous infusion and Group V: cirrhotic rats and bolus infusion of saline. There were no statistical differences in serum concentrations of ANF (232 +/- 75 vs 195 +/- 42 pg/ml) and Renin concentration (182 +/- 24 vs 171 +/- 34 ng/ml/hour) between controls and rats with cirrhosis. However, Aldosterone levels were elevated in cirrhotic rats in basal conditions as compared to controls (1197 +/- 287 vs 475 +/- 88 pg/ml; p < 0.001). The volume overload caused a paradoxical decrease of ANF in cirrhotic rats (124 +/- 15 and 122 +/- 17; p < 0.001). On the other hand, no changes were observed in Renin and Aldosterone after volume expansion. These results suggest the existence of a hemodynamic response to compensate the volume overload. Other studies are necessary to confirm this hypothesis.
  Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 05/1994; 85(4):261-6. · 1.55 Impact Factor
• Article: [Importance of portal hypertension in the release of tissue plasminogen activator (t-PA): experimental study in the rat].

  F Barrao Comps, J Lasierra Cirujeda, G Ceña Lázaro, M J Aza Pascual-Salcedo, M J Morandeira García, M E Barrao Yoldi, J González Gallego
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  ABSTRACT: Tissue plasminogen activator (t-PA) activity was studied in three different experimental models of male Wistar rats; hepatic lesion without portal hypertension, portal hypertension without hepatic lesion and portal hypertension plus function liver suppression by ligation of both portal vein and hepatic artery. t-PA activity was higher in animals with portal hypertension alone than in animals with only hepatic lesion (146%). Maximal values were present in animals with functional liver suppression (1.774% vs. controls, 248% vs. hepatic lesion and 169% vs. portal hypertension only). These results suggest that both reduced hepatic t-PA clearance and portal hypertension could be involved in the increased t-PA activity normally appearing in chronic liver disease.
  Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 09/1993; 84(2):105-8. · 1.55 Impact Factor
• Article: [Behavior of glycolic acid in comparison with other biological parameters in experimental extrahepatic cholestasis].

  F Esteva Díaz, J Ducons García, G Ceña Lázaro, M Márques Galván, E Gómez Díaz Bravo, F Barrao Comps
  Revista española de las enfermedades del aparato digestivo 11/1987; 72(4 Pt 2):435-8.
• Article: [Study of the response of c-AMP, glucose and free fatty acids to stimulus with glucagon in rats in experimental hepatic cirrhosis].

  F Esteva Díaz, J Ducons García, G Ceña Lázaro, M Márquez Galván, F Barrao Comps
  Revista Clínica Española 05/1987; 180(7):364-7. · 2.01 Impact Factor
• Article: [Implications of the arterialization of the sinusoid in its capillarization and in the maintenance of portal hypertension in the cirrhotic patient].

  G Ceña Lázaro, F Barrao Comps, J L Omiste Martínez, J Ducóns García, S Rojo Puente, M Laquidaín Hergueta, J Bueno Gómez
  Revista española de las enfermedades del aparato digestivo 03/1987; 71(2):111-3.
• Article: [The cyclic AMP, insulin and glucose responses to glucagon stimulation in patients with liver cirrhosis according to the stage of development ].

  F Esteva Díaz, J Ducóns García, G Ceña Lázaro, M Márquez Galván, G Juste Rullo, F Barrao Comps
  Revista Clínica Española 12/1986; 179(7):347-51. · 2.01 Impact Factor