F Neczyporenko

Université Libre de Bruxelles, Bruxelles, Brussels Capital Region, Belgium

Are you F Neczyporenko?

Claim your profile

Publications (5)8.48 Total impact

  • F Neczyporenko, J André, K Torosian, A Theunis, B Richert
    [Show abstract] [Hide abstract]
    ABSTRACT: Background Nail apparatus melanoma (NAM) is a rare melanocytic neoplasm with pejorative prognosis often related to late diagnosis. Early diagnosis at in situ stage (NAMis) is difficult, but essential to improve prognosis. NAMis management is not well established yet. Removal of the whole nail unit has been advocated in several small series as a potential treatment for NAMis. Objective To report and assess functional' or conservative' surgery for NAMis and evaluate its long-term oncologic safety. Methods Retrospective study of cases diagnosed in the University Hospital Saint-Pierre collected over a 13year period and compared with the published data. ResultsEleven cases of NAMis were identified: 73% concerned females. Thumb and first toe were the most affected digits (63% of total). Monodactylic longitudinal melanonychia (LM) was the most frequent presentation (92%). Mean diagnosis delay was 5years. Diagnosis was suspected on the basis of clinical and dermatoscopic signs and was confirmed by pathological examination. All patients underwent complete nail unit removal with 6mm security margins around the anatomic boundaries of the nail. Two late local recurrences were observed at 7 and 11years follow-up. Conclusions Our series, the largest up to now, demonstrates that functional surgery' is a rational approach for NAMis with an excellent oncologic safety at 5years. However, this study suggests that a very long-term follow-up is mandatory, as recurrences may appear late.
    Journal of the European Academy of Dermatology and Venereology 03/2013; 28(5). DOI:10.1111/jdv.12131 · 3.11 Impact Factor
  • Florence Neczyporenko, Arlette Blondeel
    Contact Dermatitis 09/2010; 63(3):171-2. DOI:10.1111/j.1600-0536.2010.01764.x · 3.62 Impact Factor
  • C Martin, F Neczyporenko, S De Wit
    [Show abstract] [Hide abstract]
    ABSTRACT: Pyoderma gangrenosum is a rare, chronic, non infectious ulcerative skin disease. It is an inflammatory neutrophilic dermatosis. It is associated in 50% with a systemic disorder. Unfortunately, there are no randomized controlled studies concerning PG treatment. Immunosuppression is the mainstay of treatment and includes local and systemic measures, with high risk of potential side effects. Multidisciplinary care to patients with PG is essential for best management. We present a patient with pyoderma gangrenosum which was admitted in our Infectious Diseases Unit and first treated based on an infectious assumption. Collaboration between internists and dermatologists led to quick correct diagnosis, PG management, exclusion of an associated systemic disorder and management of further complications.
    Acta clinica Belgica 07/2010; 65(4):265-8. DOI:10.1179/acb.2010.056 · 0.59 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Since its first use 40 years ago, 5-fluorouracil (5-FU) has become an unquestionable component of colorectal cancer treatment. It is also now well established that infusional 5-FU administration, in combination with leucovorin, is associated with better tolerance and at least equal efficacy than bolus administration. However, requiring catheter and infusion pumps, infusional 5-FU administration is costly, rather inconvenient for patients and potentially associated with morbidity, initiating subsequent oral chemotherapy development. To address intravenous 5-FU related issues, oral fluoropyrimidines have been developed such as capecitabine, preferentially converted to 5-FU into tumour cells, and UFT, able of bypassing intestinal dihydropyrimidine dehydrogenase. We discuss in this article current oral fluoropyrimidines achievements in colorectal cancer management.
    Acta gastro-enterologica Belgica 01/2004; 67(4):331-3. · 0.58 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cutaneous Paget's disease (PD) is a rare entity, predominantly involving the breasts. Anal involvement is rather exceptional, and can be associated with underlying malignancies, among which prostate and rectal adenocarcinoma. We report the case of a 71-year-old man suffering from a long history of anal itching, associated with an erythematosquamous lesion of the right buttock extending up to the anus. The diagnosis of perianal PD (PAPD) was confirmed by histopathological demonstration of Paget's cells from a biopsy performed after ineffective topical treatment. Radiological and further clinical inspections allowed us to exclude any synchronous malignancy. A first-step surgery consisted in coelioscopic diverting sigmoid colostomy, along with multiple perianal, anal and rectal biopsies revealing an anal canal involvement. Coelioscopic abdominoperineal surgery and a wide cutaneous excision were then performed. Histopathological analysis revealed positive posterior margin, requiring further excision. No adjuvant therapy was prescribed, and to this day, after a one-year and a half follow-up, the patient remains disease-free. Our case report and review of PAPD stress that appropriate management is required to improve the poor prognosis of this rare affection.
    Acta gastro-enterologica Belgica 67(2):228-31. · 0.58 Impact Factor