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Publications (7)17.24 Total impact

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    Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology 04/2012; 108(4):284-5. · 3.45 Impact Factor
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    ABSTRACT: En nuestro hospital se ha realizado un estudio para validar la seguridad de las pruebas cutáneas con fluoresceína y su sensibilidad. Se estudiaron 341 pacientes candidatos a angiografía con fluoresceína, con SPT con fluoresceína al 20% e ID al 2%, realizándose lecturas inmediata (20 minutos) y tardías (24 horas) de dichas pruebas. Se encontraron 11 pacientes con pruebas positivas: un SPT, 8 ID en lectura inmediata y dos tardías. En la paciente con SPT positivo no se administró fluoresceína por motivos éticos, ya que se trata de una mujer de avanzada edad y múltiple patología asociada, además según algunos autores, la positividad del SPT se asocia a alta probabilidad de complicaciones anafilácticas (3). No así ocurre con la ID: de los 8 pacientes con positividad inmediata en la misma, 4 dieron su consentimiento para realizar pruebas de provocación endovenosa, tolerándose sin complicaciones en todos ellos. En los dos pacientes con positividad en la lectura de las 24 horas se realizaron pruebas epicutáneas, que fueron positivas en una paciente con la aparición de rash generalizado y negativas en el otro. En estos dos pacientes no se administró la fluoresceína. Los 330 pacientes restantes toleraron la prueba sin complicaciones, por lo que consideramos que las pruebas cutáneas con fluoresceína tienen un valor predictivo negativo y sensibilidad altos, especialmente en el caso del SPT (4). La ID, de acuerdo con lo publicado por diversos autores (3) y con nuestra experiencia (Pérez EM, Matheu V et al: Validez de las pruebas cutáneas con fluoresceína; XXIV Congreso de la Sociedad Española de Alergia e Inmunología Clínica, Marbella 20-23 de octubre de 2004, comunicación póster), parece ser de menor utilidad, aunque puede tener un papel en el estudio de reacciones tardías.
    Archivos de la Sociedad Espanola de Oftalmologia 09/2005; 80(8):441-2.
  • Archivos de la Sociedad Espanola de Oftalmologia 01/2005; 80(8).
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    ABSTRACT: The standardisation of allergenic extracts in micrograms of the major allergen has encouraged the search for new treatment schedules, with the purpose of shortening the number of visits and doses required to reach the maintenance dose without eliciting a greater risk of adverse reactions for the patients. With this objective, a prospective multicentre pharmacovigilance study was designed that included 200 patient with allergic rhinoconjunctivitis and/or allergic asthma sensitised to mites (Dermatophagoides pteronyssinu and/or farinae). The dose increment period was carried out using a cluster schedule, where the optimal dose wa reached after 4 visits, administering two doses in each visit. The duration of the study was 5 months and a total o 1902 doses were administered. At the end of the trial, 31 adverse reactions in 23 patients were recorded. Six of these were systemic (0.3% of t administered doses) recorded in 6 patients (3% of the sample). One was an immediate reaction (grade 1) and delayed (4 mild and 1 moderate). Two were asthmatic exacerbations, 2 cutaneous reactions, 1 rhinitis and 1 an unspecific symptom (not IgE-mediated). Two appeared upon administration of the first vial and the remaining 4 after administration of the third cluster. Therefore, the schedule tested presents an adequate tolerance profile, suggesting savings (compared to th conventional schedule of 13 doses per patient) of 1800 visits and 1000 treatment doses in the whole study.
    Journal of investigational allergology & clinical immunology: official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 02/2004; 14(3):193-7. · 1.89 Impact Factor
  • Allergy 05/2001; 56(4):357-8. · 5.88 Impact Factor
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    ABSTRACT: Most published studies on changes of specific IgG or its subclasses as a response to stimuli by allergens have been performed on patients under immunotherapy. There are few reports analysing the response to immunoglobulins in patients exposed to allergens in their natural habitats. The aim of this work was to discover the natural history of Apis specific IgG (IgG-ap) and IgG4 (IgG4-ap) levels in beekeepers from the Canary Islands. We studied 242 beekeepers (Bks). We used a questionnaire and measured total IgE and seric Apis specific IgE (IgE-ap), IgG-ap and IgG4-ap against Apis mellifera venom. All Bks had IgG-ap and IgG4-ap. IgE-ap was positive in 160 Bks (65.6%), but only 92 (37.6%) Bks were considered sensitized. IgG-ap and IgG4-ap showed significant correlation (r = 0.84); IgE did not correlate with IgG-ap or IgG4-ap. There was no seasonal variation in IgG-ap or IgG4-ap. The group of sensitized Bks had significantly lower IgG-ap and IgG4-ap levels (P < 0.05). The groups with longer beekeeping activity showed significantly higher levels of IgG-ap and IgG4-ap (P < 0.001). Bks with locals reactions had significantly higher IgG-ap and IgG4-ap than Bks who reported systemic reactions (P < 0.05). Our study showed that IgG-ap and IgG4-ap appear to increase in Bks, either according to their beekeeping experience or in subjects with local reactions after bee stings.
    Clinical & Experimental Allergy 05/1997; 27(4):418-23. · 4.79 Impact Factor
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    ABSTRACT: Beekeepers (Bks) represent a high allergic risk population against Hymenoptera because of their frequent exposure to bee stings. Most published studies show different percentage of sensitization and systemic reactions with to another groups of population. With the aim to know the prevalence and type of allergic reaction in Bks from the Canary Islands, 246 subjects were studied prospectively. A questionnaire was developed and skin test and specific IgE determination against Apis mellifera, Vespula and Polistes venom were performed. One hundred and twenty eight subjects had presented at least one reaction greater than merely local. In 83.5% of these subjects subsequent stings caused reactions of lesser intensity. Specific IgE in serum for Apis mellifera was positive in 126 BKs, for Vespula in 27 and for Polistes in 9. We found that the group of BKs sensitized to Apis was significantly higher among atopics BKs (p < 0.001) and with fewest years of working experience in beekeeping (p = 0.0134). This study showed that sensitization to Hymenoptera is higher in beekeepers with less than 5 years working experience and who are sensitized to another allergens.
    Allergologia et Immunopathologia 01/1995; 23(3):127-32. · 1.23 Impact Factor