Publications (2)1.01 Total impact
Article: [Biological side-effects of potential antitubercular agents. VIII. Antimitotic activity of thiobenzamides substituted on the nitrogen thioamide function group or on the aromatic cycle in position 2].Ceskoslovenská farmacie 06/1985; 34(3-4):135-8.
[show abstract] [hide abstract]
ABSTRACT: It is very difficult to meet all prerequisites for the optimization of the tuberculostatic action of thiobenzamides. On the one hand, a strongly polarized C=S bond of the thiocarbamido group is necessary, and on the other hand, the value of the Hammett constant must be positive (to prevent hepatotoxicity). The conjugated system can be extended to reduce the excitation energy of the eta-eta electronic transition. However, the lipophilicity should not be overincreased (to avoid the risk of increased antimitotic activity and acute toxicity). Of the culture media, the Sauton system seems to be best suited since it is the most simple. However, the culture medium according to Sula comes closest to in vivo conditions as it contains proteins and is devoid of surfactants.Pharmazie 01/1984; 38(12):874-6. · 1.01 Impact Factor