Evagelos F Kalfarentzos

Shanghai Jiao Tong University, Shanghai, Shanghai Shi, China

Are you Evagelos F Kalfarentzos?

Claim your profile

Publications (8)6.36 Total impact

  • Chunyue Ma · Zhuowei Tian · Evagelos Kalfarentzos · Yue He
    [Show abstract] [Hide abstract]
    ABSTRACT: Surgical reconstruction of extensive retromolar and lateral buccal defects after oncologic resection remains a major challenge because early and aggressive invasion by retromolar malignancies generally entails wider resection of several local anatomic structures to attain tumor-free margins. The superficial circumflex iliac artery perforator (SCIP) flap, which is a promising candidate with multiple advantages, provides a better choice of quality and esthetics for such reconstruction. Three patients (median age, 44.7 yr; age range, 23 to 63 yr) diagnosed with retromolar or lateral buccal squamous cell carcinoma (or mucoepidermoid carcinoma) underwent ablative surgery and simultaneous SCIP flap reconstruction. Preoperative computed tomographic angiographic (CTA) and color ultrasonographic images were used for confirmation and positioning of the SCIPs. Volumes of defects and corresponding SCIP flaps were recorded and analyzed. In addition, pre- and postoperative functions of speech, swallowing, and mouth opening and donor-site morbidity were compared. The SCIP flaps were raised according to information gathered from CTA and sonographic imaging. The median pedicle length reached 8.2 cm and the flap sizes ranged from 5 × 6 to 6.0 × 8.0 cm. All flaps survived uneventfully during the perioperative period and subsequent follow-up showed no recurrence. Compatible donor-recipient volume, easy harvesting, acceptable postoperative functions, and inconspicuous donor-site scars were regarded as the main advantages of the SCIP flaps. For defects after resection of retromolar and lateral buccal tumors, the SCIP flap might play an innovative and supplementary role to traditional soft tissue reconstruction approaches. Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
    Journal of Oral and Maxillofacial Surgery 01/2015; DOI:10.1016/j.joms.2014.12.022 · 1.28 Impact Factor
  • Evagelos Kalfarentzos · Chunyue Ma · Zhuowei Tian · Hanguang Zhu · Yue He
    [Show abstract] [Hide abstract]
    ABSTRACT: The purposes of this study were to evaluate the clinical application and efficacy of the dorsalis pedis fasciocutaneous flap in the reconstruction of oral cavity defects and to assess the associated donor-site morbidity. From September 2009 to December 2012, 7 patients with associated oral cavity defects resulting from tumor resection underwent reconstruction with a dorsalis pedis fasciocutaneous flap. Surgical anatomy and harvesting procedure of the dorsalis pedis flap are described. Special consideration was given to the associated donor-site morbidity. All flaps survived without any complications. All 7 flaps were based on the dorsalis pedis artery and the greater saphenous vein for perfusion and drainage respectively. In all 7 cases, the donor site was closed with a full-thickness skin graft, with no associated healing complications or functional deficit of the foot. The resulting scar was well hidden in the lower extremity. The dorsalis pedis fasciocutaneous flap is a thin and pliable flap sharing many similarities with the radial forearm flap, thus making it ideal for intraoral reconstruction. Proper intraoperative and postoperative care of the donor site can result in minimal morbidity, as shown in this study. This flap may provide an ideal alternative to the radial forearm free flap, with the added advantages of a well-hidden scar and a high level of patient satisfaction. Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
    Journal of Oral and Maxillofacial Surgery 08/2014; 73(2). DOI:10.1016/j.joms.2014.08.001 · 1.28 Impact Factor
  • Source
    Yue He · Chenping Zhang · Guanglong Liu · Zhuowei Tian · Lizhen Wang · Evagelos Kalfarentzos
    [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: To present the clinical, imaging, pathological and immunohistochemical features of giant cell angiofibroma (GCA). In this paper we report an atypical case of a GCA extending from the parotid to the parapharyngeal space. The lesion was being treated as a vascular malformation for one year prior to surgical removal. We summarize the clinical manifestations, imaging, pathological and molecular features of this rare disease.After complete surgical removal of the tumor, immunohistochemical analysis revealed strong positivity for the mesenchymal markers vimentin, CD34, CD31 and CD99 in neoplastic cells. Tumor proliferation antigen marker Ki67 was partly positive (<5% of cells). Tumor cells were negative for muscle-specific actin, epithelial membrane antigen, smooth muscle actin, cytokeratin pan, S100, desmin, glial fibrillary acidic protein, myogenin, MyoD1 and F8. The morphological and immunohistochemical profile was consistent with the diagnosis of GCA. GCA is a rare soft tissue tumor that can easily be misdiagnosed in the clinical preoperative setting. In view of the clinical, pathological and molecular features of the tumor, complete surgical removal is the current optimal treatment option, providing accurate diagnosis and low to minimal recurrence rate.
    World Journal of Surgical Oncology 04/2014; 12(1):117. DOI:10.1186/1477-7819-12-117 · 1.20 Impact Factor
  • Labros Goutzanis · Evagelos F Kalfarentzos · Vassilis Petsinis · Nick Papadogeorgakis
    [Show abstract] [Hide abstract]
    ABSTRACT: Werner syndrome, also called progeria of the adult and pangeria is a rare autosomal recessive disorder that affects connective tissue throughout the body. It is associated with premature ageing and an increased risk of cancer and other diseases. The mean survival for patients with Werner syndrome is 47 years. Death usually occurs when patients are aged 30-65 years because of atherosclerosis or malignant tumours. The purpose of this paper is to present a patient with Werner syndrome exhibiting a chondrosarcoma of the left temporomandibular joint and ramus. To the best of our knowledge this is the first case, of a Werner syndrome patient with an associated head and neck chondrosarcoma being reported. The diagnostic procedure followed and management of the patient are outlined in the paper as well.
    Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 01/2013; 41(7). DOI:10.1016/j.jcms.2012.11.045 · 2.60 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Pleomorphic adenoma is the most common neoplasm of the parotid gland. It is a benign tumor composed of epithelial and myoepithelial cells arranged in various morphological patterns. The most common reasons contributing to a recurrent disease are obvious or underestimated tumor spillage, incomplete excision, and violation of the pseudocapsule of the tumor. This article presents a case of gross multinodular recurrence of a parotid gland pleomorphic adenoma in a 38-year-old female patient. Upon clinical examination of the homolateral neck, multiple, painless, well-defined, palpable, nontender masses and subcutaneous nodules of the right parotid and homolateral neck region were revealed. The patient was treated with surgery and subsequent radiation therapy. Histologic examination of the resected specimen was suggestive of a recurrent pleomorphic adenoma disease. There were no signs of malignant transformation in the specimen. The diagnostic procedure followed, and management of the patient is outlined in the paper. Pleomorphic adenoma is the most common tumor of the parotid gland. In spite of being a benign neoplasm, inadequate management of the lesion may lead to problems such as local recurrence or malignant transformation. Management of recurrent tumors is challenging because the probability of subsequent recurrence increases with each recurrent episode, thus making local control increasingly difficult and damage to the facial nerve more likely.
    Oral and Maxillofacial Surgery 06/2011; 16(1):137-40. DOI:10.1007/s10006-011-0279-4
  • [Show abstract] [Hide abstract]
    ABSTRACT: Sublingual salivary gland neoplasms are extremely rare, accounting for only 0.3-1% of all epithelial salivary gland tumors. Most of the sublingual tumors are malignant, adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) being the most common histological types. The coexistence of two salivary gland tumors located in different major salivary glands is uncommon. A rare case of two simultaneous tumors of the major salivary glands, one in the sublingual and the other in the contralateral parotid gland in a female patient is reported. The diagnostic procedure followed, and the management of the patient, is outlined in the paper.
    Oral and Maxillofacial Surgery 09/2009; 13(4):221-4. DOI:10.1007/s10006-009-0168-2
  • [Show abstract] [Hide abstract]
    ABSTRACT: Dermoid cysts of the floor of the mouth and submandibular space represent an unusual clinical entity. A case of an enlarged median dermoid cyst in a young female adult causing obstruction of the airway is reported. The need of an extraoral and intraoral incision for the removal of the cyst is discussed, along with a review of the literature.
    Oral and Maxillofacial Surgery 08/2009; 13(3):181-4. DOI:10.1007/s10006-009-0165-5
  • Evagelos F Kalfarentzos · Despoina Deligianni · Georgios Mitros · Minos Tyllianakis
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to comparatively evaluate the use of a three-dimensional (3D) square-shaped plate for the treatment of mandibular angle fractures. Synthetic mandible replicas were used to evaluate the effectiveness of the 3D square plate along with three other mandibular angle plating techniques. The plating techniques consisted of: (1) a 3D miniplate (2 x 2 holes, square, 2 mm); (2) a 3D miniplate (6 x 2 holes, curved, 2 mm); (3) two miniplates (four holes, straight, 2 mm and 1.6 mm); and (4) one single miniplate (four holes, straight, 2 mm). Each group was subjected to incisal and homolateral molar region loading by a tensile materials testing machine (Monsanto Tensometer 20). Load stiffness values and peak measurements of the fracture gap distraction at the superior aspect of the mandible were measured. The mean values (+/-standard deviation) were derived and compared using one-way analysis of variance, with statistical significance set at p < 0.05. For homolateral molar loading, statistically significant differences existed within groups (p < 0.05). For incisal edge loading, no statistically significant differences were found for stiffness among the fixation methods tested. Gap distraction at the superior aspect of the mandible was limited for three of the groups tested. Under the conditions tested, the 3D square plate system provided the most favorable mechanical behavior.
    Oral and Maxillofacial Surgery 07/2009; 13(3):139-44. DOI:10.1007/s10006-009-0163-7