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Publications (2)1.43 Total impact

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    ABSTRACT: To review the Notre-Dame Hospital experience in the treatment of carcinoma in situ of the glottis by radiotherapy and to evaluate the different factors affecting local control and survival. Between January 1990 and June 2002, 61 patients presenting with carcinoma in situ of the glottis were treated with curative intent radiotherapy. No patients received either surgery or chemotherapy in the initial treatment of their cancer. The median follow-up for the entire population was 3.2 years. The local control rate was 96% and 94% at 2 and 5 years, respectively. Overall survival was 100% and 90% at 2 and 5 years, respectively. No statistically significant prognostic factor could be identified either for local control or survival. No patient experienced severe treatment complications or death. Radiotherapy offers excellent treatment results for carcinoma in situ of the glottic larynx, with few treatment complications. These results are comparable to those published in the literature and justify our choice of primary radiotherapy for carcinoma in situ of the glottis.
    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 09/2008; 37(4):572-6. · 0.71 Impact Factor
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    ABSTRACT: To assess the rate of pathologic residual neck disease and complication rates following selective neck dissection in patients with advanced head and neck carcinoma after concurrent chemotherapy (CT) and radiation therapy (RT). Two hundred sixty-four patients with advanced-stage head and neck carcinoma underwent concurrent CT and RT from 1998 to 2004 at Notre-Dame Hospital. We describe the outcome of 32 of these patients who underwent neck dissections at our institution. The median age was 56 years (35-73 years). The primary sites were the oropharynx (n = 25), followed by the larynx (n = 3), hypopharynx (n = 1), and oral cavity (n = 1), and there were two unknown primary sites. The initial neck stages were 2 N1, 19 N2, and 11 N3. The known primary sites were staged 2 T1, 10 T2, 8 T3, 10 T4, and 2 Tx. All patients received conventional RT to a dose of 70 Gy in 35 fractions concurrent with a platinum-based CT regimen The median follow-up was 20 months. The mean operative blood loss for neck dissections alone was 170 mL (SD = 158.3 mL), the mean operative time was 128 minutes (SD = 41.6 minutes), and the mean hospital stay was 3.6 days (SD = 1.7 days). There were no major surgical complications. Five minor complications were noted in four patients (12.5%). Twelve patients (38%) had pathologic evidence of persistent disease (1 of 2 N1, 7 of 19 N2, and 4 of 11 N3). Cervical neck dissection is a safe procedure following concurrent CT and RT and is still indicated if there is clinical or radiologic evidence of disease persistence in the neck. We experienced no major surgical complications and few minor complications. The pathologic residual rate was 38%.
    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 09/2008; 37(4):452-6. · 0.71 Impact Factor