D D Kakhiani

Publications of D D Kakhiani

• Effects of low ethanol doses on heart rhythm in rabbits.

  Authors: K Sh Nadareishvili, I I Meskhishvili, D D Kakhiani, G L Ormrtsadze, M T Khvedelidze, E T Chitanava

  Bulletin of experimental biology and medicine. 10/2004; 138(3):271-5.

  Effects of low ethanol doses on the vagosympathetic mechanisms of heart rhythm regulation were studied in rabbits. Analysis of heart rhythm variability showed that single intragastric administrationEffects of low ethanol doses on the vagosympathetic mechanisms of heart rhythm regulation were studied in rabbits. Analysis of heart rhythm variability showed that single intragastric administration of 0.5 mg/kg ethanol caused tachycardia in animals with initial predominance of vagal activity and bradycardia in animals with predominating sympathetic mechanisms. This was associated with general activation of all regulatory effects on the heart rhythm and a drastic increase in power spectrum for all frequency ranges, though with a certain deficiency of vagal effects. However, after 24 h the vagal component of the spectrum drastically increased in animals of both groups, while other parameters did not differ from the control. Presumably, this rebound can be used as a physiological marker, ethanol tolerance measure, formation of the abstinence syndrome and liability to alcoholism.

• Heart rate variability in Chinchilla rabbits.

  Authors: K Sh Nadareishvili, I I Meskhishvili, D D Kakhiani, G L Ormotsadze, G T Nazarishvili, M G Gvasalia, M T Khvedelidze, V Ya Sandodze

  Bulletin of experimental biology and medicine. 01/2003; 134(6):568-70.

  Temporal and spectral parameters of heart rate variability were studied as criteria for classification of mature Chinchilla rabbit population according to their basal neurovegetative status. TheTemporal and spectral parameters of heart rate variability were studied as criteria for classification of mature Chinchilla rabbit population according to their basal neurovegetative status. The absolute values of total spectral power density and individual frequency bands differed significantly in vagotonics and sympathotonics. However, standardized spectral power distributions in high-, low- and very low-frequency ranges were similar in both groups. Our results suggest that the intensity of regulatory influences on the heart at all levels of regulation, which can be evaluated by spectral analysis, is similarly distributed in both groups. Hence, the observed differences in the heart rate variability can not be explained by peculiarities in sympathovagal balance, but are determined by more universal mechanisms.