D C McLachlan

Publications (3)47.15 Total impact

• Article: Gerstmann-Sträussler-Scheinker disease with mutation at codon 102 and methionine at codon 129 of PRNP in previously unreported patients.

  K Young, C K Jones, P Piccardo, A Lazzarini, L I Golbe, T R Zimmerman, D W Dickson, D C McLachlan, P St George-Hyslop, A Lennox
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  ABSTRACT: We present two patients with Gerstmann-Sträussler-Scheinker disease (GSS), one from a previously undescribed kindred and one from the Canadian branch of a previously reported British kindred. In both patients, GSS is caused by a substitution of thymine for cytosine at codon 102 of the prion protein gene (PRNP). In each patient, we confirmed the clinical diagnosis by neuropathologic examination. The mutation, causing a substitution of leucine for proline at residue 102 (P102L) of the prion protein, has been previously reported in at least 30 other families. In the patients described here, the mutation was in coupling with methionine at PRNP codon 129.
  Neurology 07/1995; 45(6):1127-34. · 8.31 Impact Factor
• Article: Alzheimer's disease and possible gene interaction.

  P St George-Hyslop, D C McLachlan, T Tsuda, E Rogaev, H Karlinsky, C F Lippa, D Pollen, T Tuda
  Science 02/1994; 263(5146):537. · 31.20 Impact Factor
• Article: An informative microsatellite repeat polymorphism in the human neurofilament light polypeptide (NEFL) gene.

  E Rogaev, E Rogaeva, W J Lukiw, G Vaula, Y Liang, R Hancock, D C McLachlan, P H St George-Hyslop
  Human Molecular Genetics 01/1993; 1(9):781. · 7.64 Impact Factor