Claudia Knippig

Otto-von-Guericke-Universität Magdeburg, Magdeburg, Saxony-Anhalt, Germany

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Publications (11)18.69 Total impact

  • Scandinavian Journal of Gastroenterology 03/2007; 42(2):277-8. · 2.33 Impact Factor
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    ABSTRACT: Patients with familial adenomatous polyposis (FAP) are at increased risk of developing duodenal and jejunal adenocarcinomas. The aim of this study was to assess the usefulness of double-balloon enteroscopy- (DBE-) assisted chromoendoscopy for the detection and characterization of small-bowel polyps in patients with FAP. We performed a prospective evaluation of patients with clinically and genetically proved FAP who were enrolled in an endoscopic surveillance program. DBE was performed using a Fujinon intestinoscope (FN 450P 5/20; Fujinon Corp., Omiya, Japan), and chromoendoscopy was performed using indigo carmine. The severity of small bowel polyposis was based on the Spigelman-Saurin classification. Nine patients underwent DBE-assisted chromoendoscopy. Small-bowel polyps (including papillary adenomas) were detected in seven patients (88 %). The mean depth of small-bowel insertion was 180 cm (range 120-320 cm). The mean Spigelman-Saurin score was 4.6 (range 0-8). Jejunal polyps were detected in six patients (67 %). Chromoendoscopy aided in the detection of additional polyps in two patients. In one patient the polyps were flat and only visible with chromoendoscopy (biopsy confirmed these to be adenomas). Jejunal polyps and advanced neoplasms were more frequent in patients with APC gene mutations in exon 15. The following endoscopic therapies were performed: polypectomy (n = 1), duodenal mucosectomy (n = 1), and ablation therapy with argon plasma coagulation (n = 2). DBE was found to be a helpful method for the evaluation of small-bowel polyps in patients with FAP. DBE-assisted chromoendoscopy was of further assistance for the detection of jejunal polyps.
    Endoscopy 02/2007; 39(1):52-7. · 5.74 Impact Factor
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    ABSTRACT: Gastric cancer is the second most common malignancy and prognosis remains dismal. The reasons for the poor prognosis are the lack of sensitive serum markers for early detection and screening of high-risk individuals as well as the limited treatment options in advanced cancer stages. Using MALDI-TOF mass spectrometry after prefractionation of sera with magnet hydrophobic C8 coated beads sera from 14 patients with gastric cancer and 14 healthy controls mass spectra were generated. A peptide fragment was found to be highly elevated in cancer sera and was identified as fibrinopeptide A. To confirm proteome analysis of gastric cancer sera, we then screened a larger series of patients with gastric cancer (n = 99), high-risk individuals (n = 13) and normal controls (n = 111) for fibrinopeptide A serum levels. Interestingly, the mean logarithmic concentrations of serum fibrinopeptide A levels were significantly higher in cancer patients (mean 3.636 +/- 0.3738; p < 0.0001) and high-risk individuals (mean 3.569 +/- 0.4722; p < 0.05) compared to normal controls (mean 3.303 +/- 0.4012). In contrast, we observed no association of fibrinopeptide A levels with tumor stage, tumor location, presence of regional or distant metastasis, and Lauren type of gastric cancer. In conclusion, MALDI-TOF mass spectrometry of prefractionated gastric cancer sera allows the identification of potential biomarkers that may lead to the development of serum based tests for screening of high-risk individuals.
    Journal of Proteome Research 09/2006; 5(9):2152-8. · 5.06 Impact Factor
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    C. Knippig, P. Malfertheiner
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    ABSTRACT: The interesting pathophysiological interaction between Helicobacter pylori infection, type of gastritis, acid secretion and GORD complicated by weakness of study designs with small numbers of patients should not lead to confusion. The risk of gastric carcinogenesis and peptic ulcer formation against the need for possible higher doses of acid suppressive therapy for symptom control after eradication should be balanced carefully and can only lead us to one conclusion: there are more reasons that favour Helicobacter pylori eradication than to leave the bug in the stomach of your patients.
    05/2006: pages 73-80;
  • S. Wolff, S. Franke, C. Knippig, H. Lippert
    Viszeralchirurgie 01/2006; 41(2):114-118. · 0.06 Impact Factor
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    ABSTRACT: Obesity is a severe health problem in Europe and in the USA. There are many different methods to reduce patients' weight. We report a new method: gastric pacing. Gastric pacing is intended to induce early satiety through electrical stimulation of the gastric wall. We report the operative technique and the complications.
    Der Chirurg 08/2002; 73(7):700-3. · 0.52 Impact Factor
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    ABSTRACT: Primary diagnosis of hepatocellular carcinoma (HCC) by a shoulder metastasis is a rare event. A 68-year-old man was admitted with swelling of his left shoulder. No further clinical symptoms. Alcohol consumption: 1 l beer/day. On ultrasound, the clinically impressing tumor of the left shoulder showed calcifications. Histologic examination of the tumor of the shoulder showed a well-differentiated, trabecular carcinoma consistent with the metastasis of an HCC. Subsequent ultrasound of the abdomen gave evidence of liver cirrhosis. In addition, an infiltrating mass was found, which encompassed 75% of the right liver lobe and was subsequently shown by histology to be a well-differentiated HCC with identical features of the tumor of the shoulder. Further metastases with pathologic rib fractures were found on CT scan of the thorax. Based on clinical findings, laboratory investigations and imaging studies, the patient suffered from an HCC owing to ethyl-toxic liver cirrhosis stage Child C, and initially presented with a shoulder metastasis. Due to the advanced tumor stage, no curative or palliative therapy was administered. This is an interesting case of an atypical primary diagnosis of HCC. The most important information was given by the pathologists who raised the suspicion of a metastasizing HCC by examining the tumor of the shoulder.
    Medizinische Klinik 07/2002; 97(6):361-4. · 0.34 Impact Factor
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    ABSTRACT: Living conditions (e. g. domestic crowding) may influence the infection rate. Some studies suggested that the reappearance of H. pylori in H. pylori positive patients after successful eradication therapy might be a result of transmission by H. pylori positive spouses. Therefore this study has been performed to evaluate the effect of the H. pylori status of family members on the reinfection rate of H. pylori positive patients after successful eradication therapy. 108 H. pylori positive patients (64 male, 44 female, aged 48.7 years, range 18-76 years) who presented with dyspeptic symptoms for upper GI-endoscopy have been included into this study. H. pylori status has been defined by culture and/or histology, rapid urease test and serology. For eradication therapy patients received omeprazole 20 mg bd, clarithromycine 250 mg bd and metronidazole 400 mg bd. H. pylori status was controlled by (13)C-urea breath test 28 days (n = 96), 6 (n = 35), 12 (n = 28) and 24 months (n = 25) after eradication therapy. Additionally H. pylori status of 170 family members (82 spouses, 68 children, 20 siblings/parents, aged 3-83 years) was defined by (13)C-urea breath test (n = 167), upper GI-endoscopy (n = 2) or serology (n = 1). The eradication rate was 98 % (94/96). H. pylori prevalence in all family members was 40 % (56 % in spouses, 20 % in children). No reinfection has been found in successful eradicated patients within the two-years follow-up. These results suggest that reinfection is not dependent on the H. pylori prevalence in family members and that H. pylori reinfection after successful eradication therapy is an unlikely event.
    Zeitschrift für Gastroenterologie 07/2002; 40(6):383-7. · 1.41 Impact Factor
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    ABSTRACT: Übergewicht ist heute in Europa und den USA ein gesundheitliches und soziales Problem. Neben den konservativen Therapiemaßnahmen Übergewicht ist heute in Europa und den USA ein gesundheitliches und soziales Problem. Neben den konservativen Therapiemaßnahmen gibt es zahlreiche Verfahren zur operativen Therapie bei Adipositas. Wir berichten über eine neue laparoskopische Operationstechnik: gibt es zahlreiche Verfahren zur operativen Therapie bei Adipositas. Wir berichten über eine neue laparoskopische Operationstechnik: das Gastric pacing. Neu ist hierbei, dass über eine elektrische Stimulation des Magens beim Patienten ein Sättigungsgefühl das Gastric pacing. Neu ist hierbei, dass über eine elektrische Stimulation des Magens beim Patienten ein Sättigungsgefühl ausgelöst wird. Der Eingriff wird hier in seiner Technik und im Hinblick auf mögliche Komplikationen beschrieben. ausgelöst wird. Der Eingriff wird hier in seiner Technik und im Hinblick auf mögliche Komplikationen beschrieben. Obesity is a severe health problem in Europe and in the USA. There are many different methods to reduce patients' weight. Obesity is a severe health problem in Europe and in the USA. There are many different methods to reduce patients' weight. We report a new method: gastric pacing. Gastric pacing is intended to induce early satiety through electrical stimulationgh electrical stimulation of the gastric wall. We report the operative technique and the complications. of the gastric wall. We report the operative technique and the complications.
    Der Chirurg 06/2002; 73(7):700-703. · 0.52 Impact Factor
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    ABSTRACT: Zusammenfassung Hintergrund: Die Erstdiagnose eines hepatozellulren Karzinoms (HCC) anhand einer Schultermetastase ist eine Raritt. Anamnese und klinischer Befund: Herr H. G., 68 Jahre alt, wurde aufgrund einer zunehmenden Schwellung der linken Schulter im April 1998 erstmalig vorstellig. Keine B-Symptomatik, Alkohol: 1 l Bier/Tag. Der krperliche Untersuchungsbefund ergab eine tumorse Vernderung der linken Schulter mit sonographisch darstellbaren Verkalkungen. Untersuchungen: Histologisch zeigte sich das Bild eines gut differenzierten, trabekulr wachsenden Karzinoms mit V. a. auf eine Metastase eines HCC. In der weiterfhrenden gastroenterologischen Diagnostik stellten sich im Ultraschall des Abdomens Zeichen der Leberzirrhose mit einer im rechten Leberlappen ca. 75% des Parenchyms einnehmenden, infiltrativ wachsenden, echoreichen Raumforderung dar. Das Stanzbioptat aus dem Lebertumor zeigte die dem Befund aus der Schulterbiopsie entsprechenden Tumorformationen eines hochdifferenzierten HCC. EinCT des Thorax wies weitere Metastasen mit pathologischen Rippenfrakturen nach. Diagnose: In Zusammenschau von Klinik, Labor und bildgebenden Verfahren (Ultraschall/CT) litt der Patient an einem metastasierten HCC auf dem Boden einer thyltoxischen Leberzirrhose im Stadium Child C mit Erstmanifestation anhand einer Schultermetastase. Verlauf: Aufgrund des fortgeschrittenen Tumorleidens wurde von einer therapeutischen Intervention abgesehen, und der Patient wurde in die husliche Versorgung entlassen. Schlussfolgerung: Dieser Fallbericht zeigt ein ungewhnliches Beispiel fr die Erstdiagnose eines HCC anhand einer atypisch lokalisierten Schultermetastase. Richtungsweisend war die histologische Verdachtsdiagnose, die zu der weiterfhrenden gastroenterologischen Diagnostik und dem Nachweis des Primrtumors in der Leber fhrte. Abstract Background: Primary diagnosis of hepatocellular carcinoma (HCC) by a shoulder metastasis is a rare event. History and Clinical Findings: A 68-year-old man was admitted with swelling of his left shoulder. No further clinical symptoms. Alcohol consumption: 1 l beer/day. On ultrasound, the clinically impressing tumor of the left shoulder showed calcifications. Investigations: Histologic examination of the tumor of the shoulder showed a well-differentiated, trabecular carcinoma consistent with the metastasis of an HCC. Subsequent ultrasound of the abdomen gave evidence ofliver cirrhosis. In addition, an infiltrating mass was found, which encompassed 75% of the right liver lobe and was subsequently shown by histology to be a well-differentiated HCC with identical features of the tumor of the shoulder. Further metastases with pathologic rib fractures were found on CT scan of the thorax. Diagnosis: Based on clinical findings, laboratory investigations and imaging studies, the patient suffered from an HCC owing to ethyl-toxic liver cirrhosis stage Child C, and initially presentated with a shoulder metastasis. Therapy: Due to the advanced tumor stage, no curative or palliative therapy was administered. Conclusion: This is an interesting case of an atypical primary diagnosis of HCC. The most important information was given by the pathologists who raised the suspicion of a metastasizing HCC by examining the tumor of the shoulder.
    01/2002; 97(6):361-364.
  • C Knippig, R Fass, P Malfertheiner
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    ABSTRACT: Functional gastrointestinal disorders are a common problem. Different noninvasive and invasive strategies have been carried out in recent years to study the role of impaired myoelectrical activity, tone, compliance, transit and perception of the gastrointestinal tract. Esophageal barostat examination and impedance measurements have been added to standard clinical methods like manometry and pH-metry for the esophagus. Bilirubin measurement allows the evaluation of duodenogastroesophageal reflux and perception can be studied by gastric barostat. Electrogastrography and tenostat test are still research tools. Rectal or sigmoid barostat examination is a new research tool to study visceral sensitivity in the lower gastrointestinal tract. New methods--like functional MRI and SPECT--are promising features for the future.
    Digestive Diseases 02/2001; 19(3):232-9. · 2.73 Impact Factor