C M Lostao

Universidad del País Vasco / Euskal Herriko Unibertsitatea, Bilbao, Basque Country, Spain

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Publications (40)67.22 Total impact

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    ABSTRACT: The relationship between phenotype distribution of Cepaea nemoralis and environmental factors was investigated at 105 sites in northern Spain, using canonical correlation analysis. Two interpretable canonical correlations were identified between the phenotype and environmental variable groups at the 0.05 level of significance, and canonical loadings were determined for each set of variables. The first canonical correlation represents the association of unbanded phenotypes with rainy and cloudy sites and of the more banded phenotypes (five banded and fused bands) with high degrees of insolation and solar radiation. The second canonical correlation separates yellow from pink phenotypes, associating the former with warm places and the latter with sunny or rainy places. These results indicate that the darkening of the shell observed may be related with climatic selective forces acting in the passage from Green to Brown Iberia climatic regions.Key words: Cepaea nemoralis, polymorphism, climatic selection.
    Genome. 02/2011; 32(5):908-912.
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    ABSTRACT: In a survey of 105 populations of Cepaea nemoralis sampled in North Spain, the distribution of morph polymorphism seems to have a climatic component. The area sampled corresponds with the two main climatic regions in the Iberian Peninsula: Green and Brown Iberia, which have an Atlantic and Continental climate, respectively. Paler colour and banding phenotypes are found in the Atlantic zone, while the dark ones are commoner in Brown Iberia. This may arise from climatic selection related to behaviour patterns, which may be particularly important in limiting situations with harsh climates.
    Biological Journal of the Linnean Society 01/2008; 35(3):217 - 227. · 2.41 Impact Factor
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    ABSTRACT: Digital patterns of a sample of monozygotic and dizygotic twins were analyzed to obtain heritability values for the four basic types of patterns: arch, tented arch, loops, and whorls. Loops have been separated according to their orientation radial or ulnar. To carry out this study, we used the Holzinger and Clark indices. The results show highest concordances for monozygotic twins except for ulnar loops of the left hand and radial ones of the right hand. Different values of heritability were found for the right and left hands, with finger I having the highest values.
    American Journal of Human Biology 05/2005; 3(1):11 - 15. · 2.34 Impact Factor
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    ABSTRACT: The present study involves the evaluation of digital dermatoglyphic traits of 2185 unrelated individuals (1152 females and 1033 males) from 17 natural valleys of the four Basque provinces (Vizcaya, Guipúzcoa, Navarra, and Alava) in the Spanish Basque Country. Univariate intervalley and between-sex comparisons were carried out by means of chi-square contingency analysis for pattern types and by means of one-way analysis of variance for ridge counts. Multivariate intervalley comparison was carried out by means of correspondence analysis for pattern types and by principal component analysis for ridge counts. The results of this study are notable for the following findings: (1) in general, all variables are significantly heterogeneous among valley populations; (2) there was a greater differentiation among the valley populations than between sexes in one valley population; (3) affinities among the intervalley populations depend on the variables considered; (4) the valley populations from Vizcaya resemble those from the Pyrenees; (5) based on interprovince comparisons, the Vizcaya and Navarra samples are the closest: (6) in general, the valley samples from Alava are the worst clustered; (7) the universality of dermatoglyphic component structure fits better in males.
    Human Biology 05/2003; 75(2):265-91. · 1.52 Impact Factor
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    ABSTRACT: Fragile X syndrome is associated with an unstable CGG repeat sequence in the 5' untranslated region of the first exon of the FMR1 gene. The present study involved the evaluation of factors implicated in CGG repeat stability in a normal sample from two Basque valleys (Markina and Arratia), to discover whether the Basque population shows allelic diversity and to identify factors involved, by using the data in conjunction with previous findings. The study was based on a sample of 204 and 58 X chromosomes from the Markina and Arratia valleys, respectively. The CGG repeat, the AGG interspersion and two flanking microsatellite markers, FRAXAC1 and DXS548, were examined. In the Markina valley, gray zone alleles (> or =35 CGG repeats) were associated with anchoring AGGs, with the longest 3' pure CGG repeats of the valley (=15), with the 5' instability structure 9+n and with one principal fragile X FRAXAC1-DXS548 haplotype 42-50. In the Arratia valley, gray zone alleles (> or =35 CGG repeats) showed the highest frequency among the Basque samples analyzed, and were associated with anchoring AGGs, with the longest 3' pure repeats (> or =20), with the 5' instability structure 9+n and with one "normal" FRAXAC1-DXS548 haplotype 38-40 (these data from Arratia suggest the existence of a "protective" haplotype). The results showed, on the one hand, differences between Markina and Arratia in factors implicated in CGG repeat instability and, on the other hand, a great similarity between the general Basque sample from Biscay and the Markina valley.
    Heredity 03/2003; 90(3):206-11. · 4.11 Impact Factor
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    ABSTRACT: Numerous studies have shown there is consistent evidence implicating genetic factors in the etiology of autism. In some cases chromosomal abnormalities have been identified. One type of these abnormalities is gaps and breaks nonrandomly located in chromosomes, denominated fragile sites (FS). We cytogenetically analyzed a group of autistic individuals and a normal population, and we examined the FS found in both samples with the aim of (1) comparing their FS expression, (2) ascertaining whether any FS could be associated with our autistic sample, and (3) examining if there are differences between individual and pooled-data analyses. Different statistical methods were used to analyse the FS of pooled and individual data. Our results show that there are statistically significant differences in the spontaneous expression of breakages between patients and controls, with a minimal sex difference. Using the method for pooled data, eight autosomal FS have preferential expression in patients and five patients were found to be positive at FS Xq27.3. With the method per-individual analysis, four FS emerged as specific in our autistic sample. Inferences of FS from pooled data were different from those of individual data. The findings suggest that although analysis of pooled data is necessitated by the problem of sparse data, analysis of single individuals is essential to know the significance of FS in autism.
    Behavior Genetics 12/2002; 32(6):397-412. · 2.61 Impact Factor
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    ABSTRACT: The genotoxicity of atenolol, a beta-blocker antihypertensive drug, both in vitro and in vivo, was cytogenetically tested for its ability to induce sister chromatid exchange (SCE) and micronuclei (MN) in cultured peripheral lymphocytes. Also, fluorescence in situ hybridization (FISH) with a centromeric probe was performed to determine the origin of the induced MN. The in vivo study was carried out, on the one hand, on four patients under antihypertensive treatment with atenolol and, on the other hand, on four matched control individuals taking an oral dose of atenolol. The in vitro study was performed on the control individuals by adding the drug to the culture medium at a final concentration similar to the levels found in plasma. When a comparison was made, the frequency of SCE did not show significant differences in any case. A statistically significant increase in the frequency of MN was detected in patients but not in control individuals either in vitro or in vivo. FISH analysis revealed statistically significant differences between patients and control individuals without the drug with respect to the frequency of centromeric signals in MN. Taking all these observations together, our data suggest that chronic exposure to atenolol resulted mainly in the induction of chromosome loss, so an aneugenic activity could be predicted. Different sensitivity to the compound was observed among control individuals. Nevertheless, all of them responded to the presence of atenolol in the same way in both assays. Interindividual variability was also reported. The intervariability seen in patients suggested an adaptive response to the chemical after long-term therapy.
    Mutagenesis 06/2000; 15(3):195-202. · 3.50 Impact Factor
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    ABSTRACT: The fragile X syndrome is an X-chromosome-linked dominant disorder with reduced penetrance. It is the most common inherited form of mental retardation. The molecular basis is usually the unstable expansion of a CGG trinucleotide repeat in the 5' untranslated region of the first exon of the FMR1 gene, which resides at chromosome position Xq27.3 and is coincident with the cytogenetic fragile site FRAXA, which characterizes the syndrome. In the Biscay province of the Basque Country the prevalence of FRAXA in a mentally retarded sample of non-Basque origin is in the range of other analyzed Spanish populations. In the sample of Basque origin we have not found FRAXA site expression and the repeat size is in the normal range. Based on this, we have examined FMR1 gene stability in normal individuals of Basque origin from the Biscay province. This study is based on a sample of 242 X chromosomes. The results from the CGG repeat region of FMR1 indicate that a prevalence of predisposing normal alleles toward repeat instability in the Basque population is 0.00% or near to it. This could be 1 of the explanations of the apparently low fragile X syndrome incidence found in the Basque mentally retarded sample analyzed by us. This low incidence does not seem to be associated with the flanking microsatellite markers.
    Human Biology 03/1999; 71(1):55-68. · 1.52 Impact Factor
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    ABSTRACT: Fragile X syndrome is the most common inherited form of mental retardation. The syndrome is associated with a CGG repeat expansion in the 5'UTR of the first exon of the FMR1 gene. This gene maps to Xq27.3 and coincides with the cytogenetic fragile site (FRAXA). The present study deals with the prevalence of fragile X syndrome among individuals with mental retardation of unknown cause from institutions and special schools from the Spanish Basque Country. Results of cytogenetic and molecular studies, performed in a group of 134 unrelated individuals (92 males and 42 females) are presented. The cytogenetic marker at Xq27.3 was identified in 12 patients. Other chromosomal abnormalities were found in two cases that this and previous studies confirmed as Angelman and Prader-Willi syndromes. Two males, in whom the cytogenetic marker was identified, were found negative for FRAXA and FRAXE expansion at the molecular level. The present study shows that the frequency of the FRAXA full mutation in individuals of Spanish non-Basque origin is in the range of other Spanish populations. In the sample of Spanish Basque origin we have not found cytogenetic FRAXA site expression, and the CGG repeat size of FMR1 gene is in the normal range. The significance of these results are discussed.
    Annales de Génétique 02/1999; 42(4):197-201.
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    ABSTRACT: We have analyzed the a-b ridge count and its fluctuating asymmetry in a sample (331 males and 290 females) from the Basque region of Alava province, Spain. Significant bimanual differences in the a-b ridge count are apparent only for females, and the sexual differences are significant for both hands. A comparison of the results in the Alava Basque population with results for other Basque populations showed sexual dimorphism. The results for fluctuating asymmetry do not support the hypothesis that if the regression of fluctuating asymmetry on the right and left hands is quadratic, the fluctuating asymmetry is a result of developmental homeostasis. Our data seem to indicate also that the factors that determine the a-b ridge count are canalized in females and males in the same way.
    Human Biology 03/1995; 67(1):121-33. · 1.52 Impact Factor
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    ABSTRACT: Genetic and environmental prenatal factors influencing the fluctuating asymmetry of the a-b interdigital ridge count are examined. From the results obtained we can conclude that fluctuating asymmetry of the a-b interdigital ridge count is poorly influenced by genetic factors. We suggest that fluctuating asymmetry of dermatoglyphics provides a good measure of developmental stability in humans, especially for males. The results also indicate that random environmental factors, acting before the 19th week of embryonic development, could be related to the differential timing of maturation of the sexes.
    Annals of Human Biology 01/1993; 20(6):557-63. · 1.48 Impact Factor
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    ABSTRACT: Palmar dermatoglyphics of a sample including 552 males and 701 females from 8 Basque valleys were analyzed. We studied the frequency of palmar pattern types and compared them using correspondence the frequency of palmar pattern types and compared them using correspondence analysis. The results of this comparative study show that there is diversity among valleys and also that this diversity depends on the trait and on sex. Genetic drift could explain this variability found in the Basque population.
    Human Biology 11/1992; 64(5):705-16. · 1.52 Impact Factor
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    ABSTRACT: A study of 100 MZ (55 female and 45 male) and 97 DZ (50 male and 47 female) same-sexed twin pairs was carried out to analyse the genetic component of the variance of the a-b, b-c and c-d interdigital ridge counts by means of the Christian method. Especially for the a-b interdigital ridge count, we found it important to analyse both sexes separately. Our results suggest that the a-b count in males seems to be more influenced by environmental factors than the other counts. For females, the three interdigital counts seem to have a strong genetic component influencing their phenotypic expression. Factor analysis with VARIMAX rotation showed each interdigital ridge count to be genetically independent.
    Hereditas 02/1992; 117(2):189-94. · 0.96 Impact Factor
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    ABSTRACT: Different analyses of genetic polymorphisms performed on the Basque population have suggested a possible heterogeneity of the Basques and a singularity of their genetic characteristics. In this paper, both aspects are analyzed by means of the genetic study of seven polymorphic systems--ACP, ADA, AK, ESD, PGD, GC, and HP--in 854 autochthonous individuals from the province of Vizcaya. The individuals were classified as being from the regions of Arratia, Guernica, Durango, Uribe, Marquina, Lea, and Bilbao, on the basis of the birthplaces of their four grandparents. Analyses for heterogeneity of the gene frequencies distribution suggest that there is a moderate genetic heterogeneity, probably produced by centuries of geographical and administrative isolation of these regions. The comparison with caucasoid populations, performed using the principal components analysis and Cavalli-Sforza and Edwards arc distance, indicates that the subpopulations of the province of Vizcaya have experienced little genetic exchange with other caucasoids and that the distribution of their genetic frequencies differentiates them from other populations.
    The American Journal of Human Genetics 09/1991; 49(2):450-8. · 11.20 Impact Factor
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    ABSTRACT: The 3 red-cell polymorphic systems acid phosphatase (ACP), adenosine deaminase (ADA) and esterase D (ESD) have been studied in a random sample of 1,112 individuals from the Basque country: The allelic frequencies obtained were ACP*A = 0.275, ACP*B = 0.718 and ACP*C = 0.007; ADA*2 = 0.021, and, ESD*2 = 0.066. The allelic frequencies have been compared with those of other Basque and other European populations. In comparison with Basques, significant differences were detected only for ACP, whereas as regards other Europeans significant differences were obtained with practically all the populations compared for the 3 genetic systems studied. The low values of the less frequent alleles, especially that for the ACP*C allele which is the lowest reported in Europe, are noteworthy.
    Human Heredity 02/1991; 41(2):93-102. · 1.57 Impact Factor
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    ABSTRACT: Fluctuating asymmetry for the digital quantitative value was analyzed in a sample of twins (mono and dizygotic) and singletons. The aim was to check if the influence of twinning on the development is expressed in a higher fluctuating asymmetry in twins than in singletons. The results have shown that significant differences exist among the three groups studied, and these differences are fundamentally expressed when the radial and ulnar counts are considered separately.
    Hereditas 02/1991; 115(1):31-5. · 0.96 Impact Factor
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    ABSTRACT: Digital dermatoglyphics of a sample from the Basque Valley of Salazar, situated in the West of the Pyrenees, were analysed. The results showed bimanual differences in both sexes, and also sexual differences for both hands. The comparative study with other Basque valleys showed that, in spite of their supposed common origin, the geographic barriers and the isolation have generated a genetic/dermatoglyphic and linguistic differentiation.
    Annals of Human Biology 01/1991; 18(3):221-33. · 1.48 Impact Factor
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    ABSTRACT: Eighty-six females and 79 males from the Basque valley of Deba were analyzed with respect to their digital patterns using correspondence analysis. We found that there was a significant sexual difference for only one type of pattern, tented arch. Also, this population was compared with other Basque valley populations and with other Spanish populations. We found great variability among Basque subpopulations, despite their supposed common origin. Dermatoglyphic distances for some traits can be interpreted as genetic distances because there is high heritability of these traits. The results of the comparison between the Deba valley population and other Spanish populations showed that the Deba population is markedly distant from the other populations.
    Human Biology 09/1990; 62(4):553-72. · 1.52 Impact Factor
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    ABSTRACT: Cepaea hortensis (Mull) is found in Spain only in the western part of the Iberian mountain range. This is the southernmost limit of its range. The most frequent colour is yellow, brown being very rare. The most frequent band patterns are 12345, fused banded and unbanded. There are associations between maximum and minimum temperatures and pink and effectively unbanded yellow phenotypes. The populations may be grouped into two zones, one located in the north and the other in the south of the sampled area. Visual predation was not observed. The marginal populations studied by us were compared with others from Northern Europe, and it was observed that pink snails are more frequent at the southern limit, and unbanded ones at the northern limit. This was interpreted as a climatic selection.
    Genetica 07/1990; 81(2):109-115. · 1.68 Impact Factor
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    ABSTRACT: Digital dermatoglyphics of an indigenous sample of 87 males and 101 females from the Urola Valley in the Spanish Basque Country are compared with those from the nine other Basque valleys previously analyzed. In both sexes of the Urola Valley, there is a very high frequency of radial loops; the mean found in this valley extends the range of variation for South European-Mediterranean populations, and it is in the superior limit of all Caucasian populations. There are bimanual and sex differences in the frequencies of whorls and loops. Contrary to what occurs normally in populations, in the Urola Valley the frequency of whorls is higher in females and the quantitative value of digital patterns is lower in males. The results of this study show the existence of heterogeneity among valleys for digital trait frequencies and for finger ridge count, and this heterogeneity is more marked in females.
    Anthropologischer Anzeiger 04/1990; 48(1):65-84. · 0.54 Impact Factor