Benjamin I Andrews

Publications (10)83.85 Total impact

• Article: Stereoselective synthesis of cyclohexanones via phase transfer catalyzed double addition of nucleophiles to divinyl ketones.

  Andrew C Silvanus, Benjamin J Groombridge, Benjamin I Andrews, Gabriele Kociok-Köhn, David R Carbery
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  ABSTRACT: Functionalized cyclohexanones are formed in excellent yield and diastereoselectivity from a phase transfer catalyzed double addition of active methylene pronucleophiles to nonsymmetrical divinyl ketones.
  The Journal of Organic Chemistry 10/2010; 75(21):7491-3. · 4.45 Impact Factor
• Article: Stereoselective double Friedel-Crafts alkylation of indoles with divinyl ketones.

  Andrew C Silvanus, Stephen J Heffernan, David J Liptrot, Gabriele Kociok-Köhn, Benjamin I Andrews, David R Carbery
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  ABSTRACT: A tandem double Friedel-Crafts reaction of indoles and nonsymmetrical divinyl ketones has been achieved. The tandem reaction forms complex [6-5-7]-tricyclic indoles in excellent yields. The reaction is completely regioselective and offers high levels of syn diastereoselectivity. The reaction is also seen to be sensitive to substrate structure and catalyst.
  Organic Letters 04/2009; 11(5):1175-8. · 5.86 Impact Factor
• Article: Asymmetric phase-transfer catalysis utilizing chiral quaternary ammonium salts: asymmetric alkylation of glycine imines.

  Barry Lygo, Benjamin I Andrews
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  ABSTRACT: O-Alkyl N-anthracenylmethyl derivatives of Cinchona alkaloids can function as enantioselective phase-transfer catalysts. By employing these catalysts in the asymmetric alkylation of glycine imines, one can generate a range of alpha-amino acid derivatives with high levels of enantiomeric excess. It is also possible to generate the catalysts in situ from commercially available chiral amines, which offers the opportunity to evaluate libraries of related structures. This latter approach has been successfully applied to a series of biphenyl quaternary ammonium salts resulting in the development of a new highly selective catalyst and opening up the potential of further expanding the range of alpha-amino acid derivatives that can be prepared.
  Accounts of Chemical Research 09/2004; 37(8):518-25. · 21.64 Impact Factor
• Article: Computational screening of combinatorial catalyst libraries.

  James L Melville, Benjamin I Andrews, Barry Lygo, Jonathan D Hirst
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  ABSTRACT: A catalyst design methodology, utilizing combinatorial synthesis in parallel with chemometric analysis, is presented, which considers the 3D steric and electrostatic properties of substituents about a constant core structure.
  Chemical Communications 07/2004; · 6.17 Impact Factor
• Article: Die katalytisch durchgeführte Desymmetrisierung cyclischer Anhydride durch nucleophile Ringöffnung mit Alkoholen

  Alan C. Spivey, Benjamin I. Andrews
  Angewandte Chemie 09/2001; 113(17):3227 - 3230.
• Source

  Available from: ic.ac.uk

  Article: Catalysis of the Asymmetric Desymmetrization of Cyclic Anhydrides by Nucleophilic Ring‐Opening with Alcohols

  Alan C. Spivey, Benjamin I. Andrews
  Angewandte Chemie International Edition 09/2001; 40(17):3131 - 3134. · 13.45 Impact Factor
• Article: Enantioselective Desymmetrization of meso-Decalin Diallylic Alcohols by a New Zr-Based Sharpless AE Process: A Novel Approach to the Asymmetric Synthesis of Polyhydroxylated Celastraceae Sesquiterpene Cores AE=Asymmetric epoxidation. Grateful acknowledgement is made to the EPSRC for a QUOTA studentship (S.J.W.) and to Pfizer (Drs. Alan R. Brown and John P. Mathias) for financial support of this work.

  Alan C. Spivey, Steven J. Woodhead, Matthew Weston, Benjamin I. Andrews
  Angewandte Chemie International Edition 03/2001; 40(4):769-771. · 13.45 Impact Factor
• Source

  Available from: imperial.ac.uk

  Article: Enantioselective Desymmetrization of meso‐Decalin Diallylic Alcohols by a New Zr‐Based Sharpless AE Process: A Novel Approach to the Asymmetric Synthesis of Polyhydroxylated Celastraceae Sesquiterpene Cores

  Alan C. Spivey, Steven J. Woodhead, Matthew Weston, Benjamin I. Andrews
  Angewandte Chemie International Edition 02/2001; 40(4):769 - 771. · 13.45 Impact Factor
• Source

  Available from: 144.206.159.178

  Article: Asymmetric alkylation of glycine imines using in situ generated phase-transfer catalysts

  Barry Lygo, Benjamin I. Andrews, John Crosby, Justine A. Peterson
  Tetrahedron Letters 43(45):8015-8018. · 2.68 Impact Factor
• Article: Stereoselective approach to C-glycosylasparagines

  Barry Lygo, Benjamin I. Andrews, Daniel Slack
  Tetrahedron Letters 44(50):9039-9041. · 2.68 Impact Factor