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ABSTRACT: The effect of pinealectomy on the adrenal growth in unilaterally adrenalectomized rats was studied by evaluation of the mitotic activity of adrenocortical cells on the fifth and tenth day after operation. It was found that pinealectomy resulted in an about double increase of mitotic index on the 5th day after unilateral adrenalectomy, and on the 10th day the stimulatory effect of pinealectomy became less significant.
Endocrinologia experimentalis 10/1990; 24(3):351-6.
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ABSTRACT: The influence of diazepam on the mitotic activity of regenerating adrenal cortex in male Wistar rats was investigated. Diazepam administration (5 mg/kg/day) was shown to inhibit the mitotic index of adrenocortical cells on the 4th and 8th day after adrenal enucleation combined with contralateral adrenalectomy. The possible mechanism of diazepam action is discussed.
Cytobios 02/1990; 61(245):85-8.
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ABSTRACT: Circadian patterns of plasma melatonin, FSH, LH, prolactin, and testosterone were studied in 10 healthy men, 20 men with oligozoospermia, and 8 men with azoospermia. Circadian rhythms were found in concentrations of melatonin and prolactin, with higher values at night in comparison with daytime levels. In patients with oligozoospermia and azoospermia an elevation in melatonin levels was observed, and an increase in melatonin concentrations occurred before onset of darkness (i.e., at 2000 h). Levels of FSH, LH, and prolactin were elevated in infertile patients. The possibilities that an increase in melatonin concentrations is either the primary feature that leads to the regression of the seminiferous epithelium or is secondary and depends on elevated gonadotropins and/or prolactin levels are discussed.
Journal of Pineal Research 02/1990; 9(2):149-57. · 5.79 Impact Factor
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ABSTRACT: The effect of diazepam on adrenocortical cell proliferation was investigated in unilaterally adrenalectomized Wistar rats by evaluation of the mitotic ratio. Diazepam administration (5 mg/kg/day) was shown to decrease the mitotic index of the adrenal cortex on the 5th day after monoadrenalectomy, while on the 10th day after the operation the inhibitory effect became insignificant. The possible mechanism of diazepam action is discussed.
Cytobios 02/1990; 64(257):81-5.
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ABSTRACT: The effect of constant light and darkness on the mitotic activity of the adrenal cortex in the course of adrenal regeneration and compensatory growth in male Wistar rats was investigated. Three separate experiments were performed in different seasons. It was found, that on the tenth day of both regeneration and compensatory growth, constant darkness decreased the mitotic activity of the adrenal cortex, and in contrast, constant light had no significant effect when compared with the controls.
Cytobios 02/1989; 59(238-239):137-42.
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ABSTRACT: The influence of nifedipine, a calcium channel antagonist, on adrenal regeneration was investigated by evaluation of mitotic activity of adrenocortical cells. It was found, that nifedipine given at a daily dose of 10 mg/kg, reduced the proliferation of regenerating adrenal cortex on the fourth day after adrenal enucleation, but the inhibitory effect of nifedipine became insignificant on the eighth day after the operation.
Cytobios 02/1989; 57(230-231):185-8.
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ABSTRACT: The role of the pituitary in the regeneration of the adrenal cortex was examined. Enucleation of the left adrenal, and removal of the right adrenal were performed in hypophysectomized rats, in sham-operated control rats and in intact control rats. The mitotic activity of adrenal regenerates was evaluated on the 5th day after enucleation. A statistically significant decrease (p less than 0.001) in the mean mitotic activity rate was noted in the hypophysectomized rats, when compared with both control groups. The results obtained indicate a significant stimulating effect of the pituitary on the regeneration of the adrenal cortex in rats.
Cytobios 02/1988; 56(226-227):145-8.
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ABSTRACT: Although there is little evidence that melatonin may have a direct antimitotic effect on various cells, it has been shown that this pineal compound may influence the cell proliferation of either normal or neoplastic cells. Therefore, the influence of melatonin on the mitotic activity of regenerating adrenal cortex of rats was studied. The mitotic activity was counted in the adrenal cortex or rats on days 2, 7, and 12 following enucleation of the adrenals. Melatonin did not influence the mitotic activity of regenerating adrenal cortex in the rat.
Journal of Pineal Research 02/1987; 4(2):197-200. · 5.79 Impact Factor
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ABSTRACT: There is some evidence that the pineal gland may influence the proliferation of both normal and neoplastic cells. The adrenal cortex has very high capacity for regeneration. Therefore, the effects of pinealectomy on the mitotic activity of regenerating adrenal cortex of rats were studied on the second, seventh and twelfth days following the enucleation of adrenals. Pinealectomy caused a significant decrease in the mitotic index of regenerating adrenal cortex after 2 and 12 days in comparison to sham operated controls.
Cytobios 02/1986; 47(189):85-8.
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Acta medica Polona 02/1986; 27(3-4):93-6.
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Acta medica Polona 02/1986; 27(3-4):97-9.
