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ABSTRACT: The aim of the study is to ascertain the antifibrotic effect of topically applied halofuginone after acute subglottic injury.
After standardized trauma to subglottic area, rats were divided into two groups: the study group that received treatment and the control group that did not. The subjects were treated with topical application of cottonoid soaked in 30 mg/dL halofuginone solution for 5 minutes after subglottic trauma. The larynx specimens were examined histopathologically by light microscopy to assess fibrosis, epithelialization, inflammation, and necrosis.
The fibrosis indexes of the treated group were significantly less than those of the control group (P < 0.05).
Topically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.
Otolaryngology Head and Neck Surgery 06/2009; 140(5):720-3. · 1.72 Impact Factor
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ABSTRACT: This study was undertaken to compare the effects of radiofrequency and injection snoreplasty on the histological structure of the soft palate in an animal model.
This is a blinded, controlled histologic evaluation of rat soft palates that underwent separate palatal interventions. Fifty rats were divided into 5 groups of 10 rats (Group 1 = injection snoreplasty [IS], Group 2 = IS + steroid, Group 3 = saline injection, Group 4 = radiofrequency ablation [RFA], and Group 5 = no intervention). The animals were sacrificed after 24 hours, 1 week, 3 weeks, and 5 weeks. Then the soft palates were subjected to histological analysis.
Histological analysis demonstrated normal remucosalization in all specimens, with fibrosis increased in Group 1. Interstitial edema was minimal in Group 2. Keratinization was most apparent in Group 4.
Radiofrequency and injection snoreplasty stiffen the rat soft palate compared with controls.
Otolaryngology Head and Neck Surgery 11/2006; 135(4):561-4. · 1.72 Impact Factor
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ABSTRACT: Nasal septal cyst is a rare complication seen after submucous resection of the nasal septum. A 25-year-old male patient presented with a complaint of nasal obstruction four years after submucous resection. Physical examination revealed a grey mass obstructing both nasal cavities and the nasal airway. Magnetic resonance imaging showed a nasal septal cyst filling the nasal cavity. Following aspiration of the cyst content, endoscopic examination was performed and perforation of the lower part of the nasal septum was noted. Under local anesthesia, superior, posterior, and anterior parts of the cyst and the left wall of the septum were endoscopically released and prepared to be used as a flap. It was sutured on the lower part of the septal perforation. No recurrence was seen during a follow-up of 18 months.
Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 02/2006; 16(2):87-90.
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ABSTRACT: The purpose of this study is to compare the effects of two different doses of 5-fluorouracil (5-FU) on closure rates and histopathological findings in myringotomy to those of simple myringotomy with saline application.
36 rats were divided into two study groups and a control group of 12 rats each. After bilateral myringotomy, we applied 5-FU 50 mg/ml in group A, 10 mg/ml in group B and saline in the control group for 10 minutes. Examination was made by otoendoscopy on days 1, 3, 5, 7, 10, 15, 20, 25. After the follow up examination, two rats from each group were randomly sacrificed on days 7, 15, 25 and 35. Both tympanic membranes were investigated for fibrosis and inflammation by light microscopy.
Most of the tympanic membranes from group B and the control group healed on the 10th day, but 16 myringotomies were patent in group A; by the 25th day, all myringotomies in all three groups were completely healed. The mean healing time was 14.62 days, 10.20 days and 10.40 days respectively in groups A, B and control. Fibrosis and inflammation were less in group A than in group B and the controls.
5-FU at a concentration of 50 mg/mL is effective in prolonging the patency of myringotomies in rat tympanic membranes, while a concentration of 10 mg/mL has no greater effect than a simple myringotomy procedure with saline application.
Medical science monitor: international medical journal of experimental and clinical research 10/2005; 11(9):BR330-4. · 1.70 Impact Factor
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ABSTRACT: The effects of topical application of Mitomycin-C (MMC) and 5-fluorouracil (5-FU) for maintaining myringotomy patency were investigated in this experimental study.
We performed simple myringotomy with a knife on 140 tympanic membranes of 70 rats. Rats were divided in two study groups and a control group. Each study group had 60 tympanic membranes, and the control group had 20. We applied Mitomycin-C (0.4 mg/ml) in Group A, 5-fluorouracil (50 mg/ml) in Group B topically, and sterile saline in the control group for 10 minutes. Examination was made with otoendoscope on days 1, 3, 5, 7, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, and 70, and patency rates were recorded.
MMC and 5-FU Groups remained open for a mean of 46.17 days and 14.62 days, respectively. The control ears healed within 10.4 days. Fibrosis of the MMC-treated group was the same as that of 5-FU-treated groups. Fibrosis of both study groups was significantly lower than that of the control group.
MMC is more effective than 5-FU, which is more effective than the simple myringotomy procedure in extending the patency of myringotomies in rat tympanic membranes (p < 0.05). Both medications are useful as an adjunct in preventing myringotomy closure.
Ontology & Neurotology 06/2005; 26(3):351-4. · 1.90 Impact Factor
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ABSTRACT: The purpose of this paper was to investigate the length, medial angulations and other structural variants of the styloid process (SP) by three-dimensional computed tomography (3D CT) in patients without any complaints related to elongated SP. We performed temporal computed tomography (CT) scans in 138 cases (87 males, 51 females) with a mean age of 34.5 (17-86). The structure, length and medial angulation of SPs were evaluated on 3D reconstructed images. SP lengths varied between 1.58 and 5.48 cm (average length 2.83 cm), and the angles varied between 60.6 and 84.1 degrees (average angle 69.4 degrees). Other morphological findings were absence of SP (3 unilateral and 1 bilateral), ossification of stylohyoid ligament (9 unilateral and 27 bilateral), irregular SP (5 unilateral and 5 bilateral), fragmentation of SP (12 unilateral and 9 bilateral), absence of the proximal part (5 unilateral and 9 bilateral) and double proximal part (1 unilateral). According to our results, we propose a new classification. Absence of SP, absence of the proximal part of SP, duplication of the proximal part of SP and angle values of SP have never been reported before according to the available medical literature. 3D CT is an effective method in the evaluation of the SP length, angulations and other morphological characteristics.
European Radiology 02/2005; 15(1):134-9. · 3.22 Impact Factor
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ABSTRACT: To discuss the differential diagnosis of two cases with mastoid mass.
Case report and review of the literature.
The study was carried out in Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey. PATIENT, INTERVENTION, AND RESULTS: Both cases were 23-year-old males. They admitted to our clinic with masses behind their left ears that had been progressively enlarging for 5 years. In both cases, coronal and axial computerized tomography scans revealed a wide-based lesion involving temporal bone cortex. The cases were operated on for diagnosis and for correction of the cosmetic deformity. Histopathological examinations were consistent with mixed and spongiotic osteoma.
Mastoid osteoma is a rare, benign tumor of bone. It may cause cosmetic deformity such as external mass or an auricular protrusion. Other neoplasms of the mastoid region, such as osteosarcoma and osteoblastic metastasis, should be considered for the differential diagnosis.
Ontology & Neurotology 04/2004; 25(2):95-7. · 1.90 Impact Factor
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ABSTRACT: Primary Hodgkin's lymphoma of the parotid gland is rare. A twenty-one-year-old man presented with a lesion that recurred two years after an excisional biopsy for a parotid gland mass. He underwent superficial parotidectomy. Frozen section examination suggested a diagnosis of Hodgkin's lymphoma. The patient was treated by radiotherapy. A complete recovery was obtained after a 27-month follow-up.
Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 08/2003; 11(1):21-4.
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ABSTRACT: Osteomas are the most frequent bone tumors of the facial bones, the most involving the frontal sinus and thus leading to symptoms of frontal sinusitis or associated complications. A twenty-one-year-old male patient presented with a growing swelling on the right side of the forehead. Examination revealed a slight facial asymmetry, a laterally shifted right orbital bulb, and disturbed vision. Cranial and orbital computed tomography showed a dense bony mass in the medial wall of the right orbit. The mass was excised totally following a bicoronal incision. The frontal and ethmoid sinuses were filled with fat tissue. Postoperatively, his vision improved to normal after two months and no complications or recurrences were detected in the sixth month.
Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 05/2003; 10(4):163-6.
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ABSTRACT: We evaluated the effects of ostioplasty and nasoantral window opening techniques employed in endoscopic surgery procedures for maxillary sinuses on mucociliary activity in rabbits.
The study included 15 adult male New Zealand white rabbits (mean weight 3.5 kg). The animals were divided into three groups equal in number. Following a vertical incision in the midline, one group underwent ostioplasty to widen the natural ostium of the maxillary sinus; a new nasoantral window was opened in another group; the other group (controls) underwent only sinus exploration. Thirty days after surgery, mucociliary activity of the maxillary sinuses was evaluated scintigraphically.
Compared with the control group, mucociliary activity decreased significantly in both groups, showing a higher deterioration with the nasoantral window opening technique (p<0.001) than that with the ostioplasty technique (p<0.05).
Since both techniques have adverse effects on the mucociliary activity of the maxillary sinuses, ostioplasty and nasoantral window opening techniques should be reserved for patients in whom they are uniquely required.
Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 04/2003; 10(4):148-52.
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ABSTRACT: Chiari malformation refers to caudal displacement of posterior fossa structures through the foramen magnum in the cervical canal and is classified according to the severity of displacement and accompanying cranial nerve and cervical pathologies. We presented a 24-year-old male patient who had isolated unilateral paralysis of the hypoglossal nerve and vagus nerve, with thyroid cartilage asymmetry. Chiari type I malformation was diagnosed by craniospinal magnetic resonance imaging. Suboccipital craniectomy and cervical 1-level large partial laminectomy were performed by the neurosurgery department. No improvement was observed in hypoglossal and vagal paralysis during an 18-month follow-up.
Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 18(2):118-20.
