[Show abstract][Hide abstract] ABSTRACT: To examine the sensory and motor response(s) of the stomach following fundic distention and to assess whether cholinergic mechanisms influence these responses.
Fundic tone, gastric sensory responses and antral motility were evaluated in eight healthy volunteers after a probe with two sensors was placed in the antrum and a highly compliant balloon in the fundus. Isobaric balloon distentions were performed with a barostat. Study was repeated in six volunteers after intravenous atropine was given.
Fundic distention induced large amplitude antral contractions in all subjects. The area under the curve was higher (P<0.05) during fundic distention. First sensation was reported at 12+/-4 mmHg, moderate sensation at 18+/-4 mmHg and discomfort at 21+/-4 mmHg. Discomfort was associated with a decrease in antral motility. After atropine was given, the area under the curve of pressure waves and fundic tone decreased (P<0.05). Sensory thresholds were not affected.
Fundic balloon distention induces an antral motor response, the fundo-antral reflex, which in part may be mediated by cholinergic mechanisms.
World Journal of Gastroenterology 11/2005; 11(42):6676-80. · 2.37 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Fecal incontinence is a common problem that disproportionately affects women and the elderly and has a significant impact on the quality of life. Incontinence is often multifactorial. Anorectal manometry, anal endosonography, magnetic resonance imaging, pudendal nerve latency, and electromyography provide morphologic and physiologic assessments of the internal and external anal sphincters, rectal motor and sensory function, rectal compliance, and rectoanal reflexes. This information, in concert, provides clues to the pathophysiology of fecal incontinence and may help to guide medical, surgical, or biofeedback therapy. These tests have also been used to assess the effectiveness of the therapeutic modalities. No data are available on the cost-effectiveness of diagnostic testing in fecal incontinence. Newer techniques, including electrophysiologic testing and morphologic imaging of the anorectum, are being pursued.
Current Gastroenterology Reports 11/2003; 5(5):406-13. DOI:10.1007/s11894-003-0054-2