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ABSTRACT: Treatment of multi-drug resistant Pseudomonas aeruginosa, which causes burn infection is a big challenge in clinics and needs novel strategies. Garlic extract has potent in vitro antibacterial activities against number of gram negative and gram positive bacteria including P. aeruginosa. The aim of this study, was to evaluate in vivo therapeutic efficacy of garlic extract in treating burn wound infection caused by P. aeruginosa in burned mouse model. Burn was induced on the back of anesthetized animals by hot water, after the hair removal. Bacterial infection was established by topical applying of highly pathogenic clinical isolate of P. aeruginosa. Potential of garlic extract on reduction of mortality was evaluated by topical application of 10% (v/v) garlic extract on burned and infected animals (treatment group 1) and was compared with two control groups: Burned and infected animals either treated with topical Silver Sulphadiazine (SSD) (1%) (treatment group 2) or left untreated (treatment group 3). The same groups were subjected to evaluate bacterial counts in organs (blood, liver, spleen and skin). Our results indicated that topical administration of garlic extract (10%) extended the survival of mice for 3-6 days, compared with survival of the untreated group. Both garlic extract and SSD treatments reduced the microbial loads in vital organs (blood, liver, spleen), compared to that of untreated control group (pP. aeruginosa.
Research Journal of Biological Sciences. 01/2007;
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ABSTRACT: Hydatidosis is one of common diseases between human and animals. Different intermediate hosts distribute this dangerous disease in a region. The aim of this study was to determine the prevalence of hydatid cyst in slaughtered animals in northwest Iran. In this cross-sectional study, a total of 5381 animals (928 cattle, 243 buffaloes, 3765 sheep and 445 goats) were inspected macroscopically for hydatid cyst. Prevalence rate of hydatid cyst in cattle, buffaloes, sheep and goats was 38.3, 11.9, 74.4 and 20%, respectively. In all cases, its prevalence in female cattle and sheep was more than male (pEchinococcus granulosus (E. granulosus) in this area.
Journal of Animal and Veterinary Advances. 01/2006;
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ABSTRACT: Fasciola spp. and Dicrocoelium dendriticum are common parasites of herbivores in most countries of the Middle East, such as Iran. In chronic infections, these parasites cause biliary cirrhosis in livers of cattle and sheep and lead to economic losses. The aim of this study was to determine the prevalence of fascioliasis and dicrocoeliasis in animals. In a cross-sectional study, the livers of 5381 animals bread with traditional methods and 1848 animals bread with commercial methods, in Ardabil province, northwestern Iran, (2004-2005) were inspected for Fasciola spp. and Dicrocoelium dendriticum. The highest prevalence of Fasciola and Dicrocoelium infections were seen in cattle and goats, respectively. There was a significant seasonal pattern for Dicrocoelium in cattle, sheep and goats (p<0.001), but in different animals there were no statistically significant differences with respect to season. The most and the least rates of total condemnation of liver were seen in cattle (19.4%) and goats (0.4%), respectively (p<0.001).
Journal of Animal and Veterinary Advances. 01/2006;
