A M Schell

Mount Sinai School of Medicine, Manhattan, NY, United States

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Publications (55)214.88 Total impact

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    ABSTRACT: OBJECTIVES. We examined whether children with and without autism spectrum disorder (ASD) differ in autonomic activity at rest and in response to auditory stimuli and whether behavioral problems related to sounds in everyday life are associated with autonomic responses to auditory stimuli. METHOD. We measured skin conductance (SC) at rest and in response to auditory stimuli as well as behavioral responses using the Sensory Processing Measure (SPM) Home Form. Participants were 25 children with ASD and 25 typically developing (TD) children, aged 5-12 yr. RESULTS. The ASD group had significantly higher resting SC and stronger SC reactivity to tones than the TD group. Correlations between SC and SPM indicated that more severe auditory behavioral difficulties were associated with higher sympathetic activation at rest and stronger sympathetic reactivity to sound. CONCLUSION. High sympathetic reactivity to sound may underlie the difficult behavioral responses to sound that children with ASD often demonstrate.
    The American journal of occupational therapy : official publication of the American Occupational Therapy Association. 09/2012; 66(5):567-76.
  • Schizophrenia Bulletin 04/2005; 31(2):211-212. · 8.49 Impact Factor
  • Schizophrenia Research - SCHIZOPHR RES. 01/2003; 60(1):264-264.
  • M.E. Dawson, A.M. Schell
    Schizophrenia Research 01/2002; 54(1). · 4.59 Impact Factor
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    ABSTRACT: This study of 31 college students employed the startle eye-blink modification (SEM) technique to index both early and later stages of attentional processing during a memory-load version of the Continuous Performance Test (CPT). Participants viewed a series of digits and pressed a button after the digit 7 of each 3-7 sequence. A startling noise burst was presented either 120 or 1,200 ms following three preselected prepulses: target (3), nontarget (non-3 and non-7 digits), or target plus distractor (3 and simultaneous tone distractor). Greater startle inhibition occurred 120 ms following target and target-plus-distractor prepulses compared with nontargets, indicating early selective attention. No difference was observed between SEM during target and target-plus-distractor prepulses, suggesting the distractor was effectively ignored. At 1,200 ms, the three prepulse types produced nondifferential inhibition, suggesting that modality-specific selective attention occurs in anticipation of the presentation of the next CPT prepulse. These findings indicate that SEM distinguishes between different early selective attention and later anticipatory attention subprocesses underlying the CPT.
    Psychophysiology 08/2001; 38(4):669-77. · 3.26 Impact Factor
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    ABSTRACT: Exaggerated startle and PTSD symptoms have been investigated primarily in relation to acute or Type I stressors. The present study examined PTSD symptoms and startle eyeblink response in relation to chronic or Type II stressors. Type II stressors were operationally defined as high levels of childhood corporal punishment and high levels of current partner aggression. This study recruited a sample of 52 women from a metropolitan community and administered several questionnaires assessing experience of corporal punishment in childhood, current intimate partner aggression and level of PTSD symptoms. Following questionnaires, women were presented with eight auditory startle probes (white noise). Results showed that both childhood corporal punishment and intimate partner aggression were associated with women's PTSD symptom scores. However, only PTSD symptom scores were associated with reduced startle. Results are discussed in light of Type I and Type II stressors, and recent suggestions in the PTSD literature that a subgroup of individuals may experience physiological suppression rather than heightened physiological reactivity.
    Psychiatry Research 04/2001; 101(2):157-69. · 2.68 Impact Factor
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    ABSTRACT: Schizophrenia patients have been shown to have a defective sensorimotor gating process as indexed by impaired prepulse inhibition of the startle eyeblink reflex. Moreover, we have previously reported that schizophrenia patients have dysfunctional attentional modulation of prepulse inhibition. The present experiment combined our previous sample of 14 schizophrenia outpatients and 12 demographically matched control subjects with a new sample of 10 outpatients and 6 control subjects. All participants performed a tone-length judgement task that involved attending to one pitch of tone (the attended prepulse) and ignoring another pitch of tone (the ignored prepulse). During this task the acoustic startle eyeblink reflex was electromyographically recorded from the orbicularis oculi muscle. The results replicated the finding of impaired attentional modulation of prepulse inhibition in the new sample of schizophrenia outpatients compared to demographically matched control subjects. Specifically, the new control group exhibited greater startle modification during the attended prepulse, whereas the new patient group failed to show this differential effect. In addition, impaired prepulse inhibition following the attended prepulse was significantly correlated with heightened delusions, conceptual disorganization, and suspiciousness as measured with the expanded Brief Psychiatric Rating Scale. These correlations were significant with prepulse inhibition to the attended prepulse but not with prepulse inhibition to the ignored prepulse. Impaired prepulse inhibition was not correlated with negative symptoms. All in all, the results support the hypothesis that impaired attentional modulation of startle prepulse inhibition reflects basic neurocognitive processes related to thought disorder in schizophrenia.
    Psychiatry Research 12/2000; 96(3):187-97. · 2.68 Impact Factor
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    ABSTRACT: The effect of prehabituation of the prepulse on startle eyeblink modification was studied in two experiments. In Experiment 1, college student participants were either prehabituated or nonhabituated to a tone that served as a prepulse in a startle modification passive attention paradigm. Neither short lead interval (60 and 120 ms) prepulse inhibition (PPI) nor long lead interval (2,000 ms) prepulse facilitation (PPF) was affected by the prehabituation procedure. In Experiment 2, participants were presented with an active attention paradigm in which one of two tone prepulses was attended while the other was ignored. One group was prehabituated to the prepulses and the other was not. Unlike the results with the passive paradigm in Experiment 1, prehabituation did significantly diminish attentional modulation of PPI and PPF. These results are consistent with the hypothesis that passive PPI and PPF are primarily automatic processes, whereas attentional modulation involves controlled cognitive processing.
    Psychophysiology 08/2000; 37(4):409-17. · 3.26 Impact Factor
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    J K Wynn, M E Dawson, A M Schell
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    ABSTRACT: The effectiveness of different types of auditory prepulses in eliciting skin conductance orienting and in producing prepulse inhibition (PPI) of the acoustic startle eyeblink was studied in two experiments. A discrete white noise prepulse produced greater PPI than either a continuous white noise, a discrete tone, or a continuous tone. The discrete white noise advantage was not due to similarity in bandwidth to the startle pulse or to a refractory effect of the prepulse. Moreover, a dissociation between PPI and skin conductance orienting was seen in both experiments. PPI using auditory prepulses appears to be dependent primarily on the acoustic characteristics of the transient portion of the prepulse, whereas skin conductance orienting is more dependent on the sustained portions of the stimulus.
    Psychophysiology 04/2000; 37(2):224-30. · 3.26 Impact Factor
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    Conference Paper: The electrodermal system
    M. E. Dawson, A. M. Schell, D. L. Filion
    Handbook of psychopysiology; 01/2000
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    ABSTRACT: Studies in our laboratory have shown that modification of startle by lead stimuli with short- and long-lead-intervals is modulated by stimulus significance. The significant stimulus in a tone duration judgement task generates enhanced short-lead-interval startle inhibition as well as pronounced long-lead-interval startle facilitation. The present study was designed to compare tones with simple visual stimuli as lead stimuli in a counterbalanced within-subjects design (Experiment I) or between-subjects design (Experiment II). The results show that auditory compared to visual lead stimuli generate more short-lead-interval inhibition but comparable amounts of long-lead-interval startle facilitation, which was significantly enhanced on to-be-attended trials independent of sensory modality. The attentional manipulation did not yield short-lead-interval effects in Experiment I, but previously reported attention effects were replicated in Experiment II. The results suggest early modality effects on startle modification, reflected by the differing levels of inhibition. Late effects of both modality and attention, however, seem to reflect a sensory modality independent process in startle modification.
    International Journal of Psychophysiology 07/1999; 32(3):239-50. · 2.04 Impact Factor
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    D L Filion, M E Dawson, A M Schell
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    ABSTRACT: The human startle eyeblink reflex is reliably modified by both cognitive and emotional processes. This review provides a comprehensive survey of the current literature on human startle modification and its psychological significance. Issues raised for short lead interval startle inhibition include its interpretation as a measure of protection of processing, sensorimotor gating and early attentional processing. For long lead interval effects, interpretations related to attentional and emotional processing are discussed. Also reviewed are clinical applications to information processing dysfunctions in the schizophrenia spectrum disorders, and to emotional processing disorders. Finally, an integrative summary that incorporates most of the cognitive findings is presented and directions for future research are identified regarding both cognitive and emotional modification of startle.
    Biological Psychology 01/1998; 47(1):1-43. · 3.40 Impact Factor
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    ABSTRACT: The differential allocation of attentional resources to attended and ignored stimuli was examined by measuring skin conductance orienting responses and secondary reaction time in relatively asymptomatic schizophrenia outpatients, demographically matched normal controls, college students putatively at risk for psychosis, and a college student control group. At-risk participants were those with extreme scores on scales for either anhedonia or perceptual aberration-magical ideation (per-mags). Compared to control groups, the patients and per-mags showed secondary reaction time results suggesting a delay in the differential allocation of attentional resources. This deficit was observed particularly in patients and matched controls with few or no skin conductance orienting responses, suggesting that impaired autonomic orienting is related to underlying cognitive-attentional vulnerability factors.
    Journal of Abnormal Psychology 06/1997; 106(2):171-81. · 4.86 Impact Factor
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    Biological Psychiatry 02/1997; 41(1):111-3. · 9.25 Impact Factor
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    ABSTRACT: In previous research on modulation of the startle eyeblink reflex, emotional effects have been demonstrated only at late probe positions, whereas attentional effects have been found at both early and late positions but only when the prepulses were affectively neutral. In Experiment 1, participants viewed emotionally valenced pictures and were instructed to attend to the duration of half of the slides. Affective modulation of the startle eyeblink occurred at long lead intervals, but attentional modulation also occurred late. In Experiment 2, participants viewed the same slides used in Experiment 1 but were instructed to attend to the duration of only the positive or the negative slides. Affective modulation occurred at both early and late probe positions, whereas attentional effects occurred only following slide offset. Early (250 ms) affective modification of startle eyeblink has not been previously reported. These results suggest that the time courses of emotional and attentional modulation of startle are variable and can occur at both early and late startle probe positions, depending on task requirements.
    Psychophysiology 12/1996; 33(6):691-7. · 3.26 Impact Factor
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    ABSTRACT: Startle eyeblink modification was examined as a measure of information processing. College students were presented with tones of 5 and 7 s duration of either high or low pitch, followed by startle-eliciting stimuli at lead intervals of 120, 2,000, 4,500, or 6,000 ms. Attention to tones was manipulated by instructing the task group to count the longer tones of either pitch. The no-task group had no instructed task. Startle eyeblink was inhibited at the short lead interval and facilitated at the long lead intervals in both groups. The task group showed greater inhibition and facilitation during attended than during ignored tones, indicating that early and late controlled processing was occurring. In the task group, the degree of facilitation appeared to reflect the degree of cognitive demands of the task. Startle eyeblink modification may provide a sensitive measure of the nature and timing of stages of processing in active and passive attentional conditions.
    Psychophysiology 04/1996; 33(2):148-55. · 3.26 Impact Factor
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    ABSTRACT: Attentional modulation of startle eyeblink was studied in college students putatively at risk for psychosis and in normal controls. At-risk subjects had extreme scores on scales for either anhedonia or perceptual aberration-magical thinking (per-mags). Subjects were presented with to-be-attended and to-be-ignored tones; white noise startle probes were presented at lead intervals of 60, 120, 240, or 2,000 ms following the onset of attended and ignored tones and during intertone intervals. Controls showed greater inhibition of startle blink at 120 ms and greater facilitation at 2,000 ms during to-be-attended than to-be-ignored tone, demonstrating attentional modulation of prepulse inhibition and facilitation. Both at-risk groups showed normal overall levels of early inhibition and late facilitation. However, per-mags failed to show attentional modulation of either inhibition at 120 ms or facilitation at 2,000 ms; anhedonics showed no modulation of inhibition and modulation of facilitation was delayed in development. The results for the per-mags are strikingly similar to those observed in schizophrenic patients and suggest that these deficits index a trait-linked vulnerability to disorders in the schizophrenic spectrum.
    Psychophysiology 06/1995; 32(3):266-73. · 3.26 Impact Factor
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    ABSTRACT: Tonic electrodermal measures have been widely used to index autonomic abnormalities in schizophrenia, whereas phasic electrodermal nonresponsiveness has been frequently used to index attentional orienting abnormalities. The primary objective of the present study was to assess whether these electrodermal abnormalities are episode indicators or vulnerability indicators. Twenty patients with a recent first episode of schizophrenia were tested during symptomatically remitted states and psychotic states. Twenty demographically matched normal controls were tested at two comparable intervals. Testing for stability of abnormalities across remitted and psychotic states allowed us to determine whether tonic and phasic electrodermal measures qualify as episode indicators or vulnerability indicators. Tonic electrodermal activity was abnormally elevated only during the psychotic state, which indicates that it is an episode indicator in schizophrenia. Phasic hyporesponsiveness relative to levels of general activation was present in both the remitted and the psychotic states, most strikingly during the psychotic state, and the proportion of patients who were electrodermally nonresponsive tended to be abnormally high during the remission test. Tonic electrodermal hyperarousal appears to be a state-sensitive episode indicator, whereas phasic electrodermal hyporesponsiveness to innocuous stimuli relative to activation level appears to be a mediating vulnerability factor.
    Archives of General Psychiatry 11/1994; 51(10):813-24. · 13.77 Impact Factor
  • D L Filion, M E Dawson, A M Schell
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    ABSTRACT: Current models of orienting suggest a relationship between the orienting response and attentional processing. This relationship was examined using two independent probe techniques to index attentional processing: secondary reaction time and startle eyeblink modification. Twenty-eight college-age subjects received intermixed presentations of to-be-attended and to-be-ignored tones. Skin conductance orienting responses were obtained during a subset of the tones. Each of the remaining tones contained either a secondary reaction time probe at lead intervals of 150 or 2,000 ms or a startle eyeblink probe presented at lead intervals of 120 or 2,000 ms. In addition, reaction time and startle probes also were presented during selected intertone intervals, and responses to these stimuli served as the baselines from which to compare changes in reaction time and blink amplitude produced by the attended and ignored tones. The results revealed that, compared with the ignored tones, the attended tones were associated with larger skin conductance orienting responses, greater blink inhibition at the 120-ms lead interval, greater blink facilitation at the 2,000-ms lead interval, and greater reaction time slowing at the 2,000-ms lead interval. Consistent with previous findings, the ignored tone was associated with greater reaction time slowing than was the attended tone at the 150-ms lead interval. The results support a relationship between elicitation of the skin conductance orienting response and attentional processes and suggest that the secondary reaction time and blink modification techniques may provide unique information regarding this relationship.
    Psychophysiology 02/1994; 31(1):68-78. · 3.26 Impact Factor
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    ABSTRACT: Event-related auditory and visual potentials were recorded from 36 attention-deficit hyperactivity disorder (ADHD) and 35 normal 6-year-old subjects engaged in a two-choice discrimination task. When normal subjects attended to stimuli in a given modality, enhanced negative (N2) and positive (P3b) responses (as compared with responses to nonattended stimuli) were found for auditory and visual target stimuli. In contrast, when ADHD subjects attended, little or no enhanced negative responses were found in either modality, and enhanced positive P3b responses were found only in response to visual target stimuli. Auditory N1, N2, and P3b and visual N2 amplitudes to attended target stimuli were significantly reduced in ADHD subjects as compared with normal subjects. No between-group differences were found for responses to nonattended stimuli. Both amplitude and latency abnormalities indicate that ADHD boys suffer from deficient preferential processing of attended stimuli. P3b and N2 abnormalities found here suggest deficiencies in two independent cognitive processes thought to be crucial to what we perceive, learn, and remember.
    Psychophysiology 02/1994; 31(1):1-10. · 3.26 Impact Factor

Publication Stats

2k Citations
214.88 Total Impact Points

Institutions

  • 1997–2001
    • Mount Sinai School of Medicine
      • Department of Psychiatry
      Manhattan, NY, United States
  • 1978–2001
    • Occidental College
      • Department of Psychology
      Los Angeles, California, United States
  • 1970–2000
    • University of Southern California
      • Department of Psychology
      Los Angeles, CA, United States
  • 1998
    • Kansas City VA Medical Center
      Kansas City, Missouri, United States
  • 1989
    • University of California, Los Angeles
      Los Angeles, California, United States