Publications (13)27.66 Total impact
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Article: Resistance patterns of multidrug-resistant tuberculosis in Western Province, Papua New Guinea.
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ABSTRACT: Few data are available on tuberculosis (TB) drug resistance patterns in Papua New Guinea (PNG) due to the lack of facilities for mycobacterial culture. Many patients from the Western Province seek care in Queensland health clinics in the Torres Strait. Since 2000, we have treated 161 TB cases from PNG, of whom 40 proved to have multidrug-resistant TB (MDR-TB; two human immunodeficiency virus positive). Drug susceptibility testing (DST) shows high levels of resistance to other drugs in the MDR-TB cases (streptomycin 93%, ethionamide 87%, ethambutol 18%, pyrazinamide 10%). No extensively drug-resistant TB (XDR-TB) has been identified. MDR-TB seems to be highly prevalent in the Western Province of PNG, and unless treatment is guided by DST, the risk of XDR-TB emerging is high.The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 04/2011; 15(4):551-2. · 2.73 Impact Factor -
Article: MYCOBACTERIUM BOVIS AS AN OCCUPATIONAL HAZARD IN ABATTOIR WORKERS
Internal Medicine Journal 03/2008; 19(4):409 - 410. · 1.54 Impact Factor -
Article: A cluster of tuberculosis associated with use of a marijuana water pipe.
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ABSTRACT: New cases of pulmonary tuberculosis (TB) were noted in a cluster of young Caucasian males, an unusual ethnic group for this disease in Queensland, Australia. It was noted that marijuana water pipe ('bong') smoking was common amongst cases and contacts. To report this cluster of TB and to investigate whether shared use of a marijuana water pipe was associated with transmission of TB. All contacts were identified and screened according to standard protocols. Cases were asked to list contacts with whom they had shared a marijuana water pipe. Five cases of open pulmonary TB were identified clinically and on sputum culture, and all isolates of Mycobacterium tuberculosis were identical on typing. Of 149 contacts identified, 114 (77%) completed screening, and 57 (50%) had significant tuberculin skin test (TST) reactions on follow-up. Of 45 contacts who had shared a marijuana water pipe with a case, 29 (64%) had a significant TST reaction. Sharing a marijuana water pipe with a case of pulmonary TB was associated with transmission of TB (OR 2.22, 95 % CI 0.96-5.17), although the most important risk factor for acquiring TB infection in this cluster was close household contact with a case (OR 4.91, 95% CI 1.13-20.70).The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 10/2003; 7(9):860-5. · 2.73 Impact Factor -
Article: Tuberculosis-related deaths in Queensland, Australia, 1989-1998: characteristics and risk factors.
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ABSTRACT: To review factors associated with TB-related deaths in Queensland, Australia. Review of data for TB patients dying before treatment completion; demographic and clinico-pathological comparison of TB-related deaths with other notified patients after exclusion of losses to follow-up; matched case-control study of co-morbid conditions in patients under 75 years. Of 1003 tuberculosis cases notified between 1989 and 1998, 127 died before completing anti-tuberculosis treatment. Tuberculosis was the main cause of death in 53 cases, a significant contributor in 34 and unrelated in 40, giving a TB-related case fatality rate of 8.7%. Decedents were older on average, except among indigenous Australians (IA); age-adjusted case fatality rates did not vary significantly among ethnic groups. Pulmonary and disseminated TB, coexistent malnutrition, renal disease and liver disease increased the risk of death. HIV infection increased the risk of dying, but was uncommon among Queensland cases. Neither sputum smear positivity nor drug resistance was associated with risk of death. Twenty-five TB-related deaths occurred before diagnosis, with significant overrepresentation of IA. Most had serious co-morbidities and symptomatic pulmonary disease. Seven socially or geographically isolated decedents did not access documented health care for tuberculosis. Fatality was related to older age, disseminated disease and co-morbidity. Dying undiagnosed from tuberculosis was associated with respiratory co-morbidity and social and geographical isolation, mainly in the aged in low TB risk populations and in IA in remote regions.The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 09/2003; 7(8):742-50. · 2.73 Impact Factor -
Article: Tuberculosis notifications in Australia, 1999.
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ABSTRACT: Australia has one of the lowest incidence of tuberculosis in the world. The crude annual notification rate for tuberculosis (TB) has remained stable at between 5 and 6 per 100,000 population since 1991. In 1999, there were a total of 1,159 TB notifications in Australia of which 1,117 were new TB cases, and 42 were relapsed cases. The corresponding annual notification rate for new and relapsed TB was 5.9 and 0.2 per 100,000 population respectively. People born overseas accounted for 83 per cent of the notified cases. TB notification rates remain highest among overseas-born residents from high prevalence countries, and indigenous Australians. The lowest rates of disease are in the non-indigenous, Australian born population and data from the last 7 years indicate that the rate of tuberculosis in this population is continuing to fall.Communicable diseases intelligence 12/2001; 25(4):254-60. -
Article: Patient and health care system delays in Queensland tuberculosis patients, 1985-1998.
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ABSTRACT: Queensland tuberculosis (TB) control centre QTCC). To investigate patient and health care system delays in the diagnosis of active TB in Queensland. Analysis of data extracted from the QTCC database and review of charts. Symptomatic patients with bacteriologically or histologically proven TB were considered as a total group and a pulmonary smear-positive (PSP) group. The median patient delays were 29 days (total group) and 30 days (PSP group). The median health care system delays were 22 days (total group) and 11 days (PSP group). There were significant trends towards increasing health care system delays with increasing age and longer residency of migrants in Australia. Health care system delays were significantly longer for females and those aged over 45. Migrants from countries of high TB incidence and indigenous Australians had shorter health care system delays compared to non-indigenous Australians. Common reasons for diagnostic delays of more than 90 days were failure to perform appropriate investigations and misdiagnosis of chest X-rays. Physicians need to consider including TB in the differential diagnosis in older age groups and migrants with longer residency in Australia. There should be a low threshold for obtaining chest X-rays and sputum samples in patients with persistent cough.The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 12/2001; 5(11):1021-7. · 2.73 Impact Factor -
Article: Tuberculosis notifications in Australia, 1998.
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ABSTRACT: Since the inception of the National Mycobacterial Surveillance System (NMSS) in 1991, annual crude notification rates for tuberculosis have remained stable at between 5 and 6 per 100,000 population. In 1998, there was a total of 923 TB notifications in Australia of which 884 were new TB cases, and 39 relapsed cases. The corresponding annual crude notification rate for new and relapsed TB was 4.72 and 0.21 per 100,000 respectively. Seventy-seven percent of notifications that had a country of birth reported were overseas born. In keeping with trends observed over recent reporting years, the populations for which notified TB rates are highest include the overseas born from high prevalence countries and Indigenous Australians. The lowest rates of disease have continued to be reported in the non-Indigenous, Australian born population. Surveillance reports over the last seven years indicate that the rate of disease in this population is gradually declining.Communicable diseases intelligence 02/2001; 25(1):1-8. -
Article: Missed opportunities for prevention of tuberculosis.
The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 05/1998; 2(4):345-7. · 2.73 Impact Factor -
Article: Two cases of Merkel cell carcinoma cured by intratumor injection of natural human tumor necrosis factor.
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ABSTRACT: Two patients were treated with intratumor injection of natural human tumor necrosis factor for recurrent or primary Merkel cell carcinoma. In both patients, local chemotherapy achieved complete tumor regression without causing ulceration or scarring. These results suggest that intratumor injection of natural human tumor necrosis factor may be very effective for the treatment of Merkel cell carcinoma.Plastic & Reconstructive Surgery 03/1997; 99(2):547-53. · 3.38 Impact Factor -
Article: What's in a name ... TB or not TB?
The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 03/1997; 1(1):91-2. · 2.73 Impact Factor -
Article: Treatment of nevus Ota: combined skin abrasion and carbon dioxide snow method.
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ABSTRACT: Thirty-seven patients with nevus Ota were treated by skin abrasion-carbon dioxide snow therapy. Data obtained from 24 patients (including 5 infants) who completed treatment were analyzed to determine the number of treatment courses and to assess the outcome by color and histologic type. The 5 infants completing treatment received a mean of 10 courses of carbon dioxide snow therapy. Excluding these infants, the mean number of treatment courses was 3 for skin abrasion and 16 for carbon dioxide snow therapy. The therapeutic outcome was satisfactory, being graded as "excellent" in 6 patients, "excellent to good" in 6 patients, "good" in 10 Patients, and "fair" in 2 patients. None of the patients had a "poor" outcome. Darker lesions were generally less responsive to treatment. Lesions with melanocytes in the superficial dermis showed a better response with fewer courses of treatment. Those with melanocytes throughout the whole dermis generally had a poorer outcome. The results confirm that the benefits of this procedure are limited by the associated pain and the need for great skill and a long treatment duration.Plastic & Reconstructive Surgery 04/1996; 97(3):544-54. · 3.38 Impact Factor -
Article: Pectoralis major myocutaneous flaps in rats.
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ABSTRACT: A new neurovascular, island, myocutaneous flap, including the pectoralis major, was created in a rat model. This model is useful for the observation of muscle degeneration and skin changes due to ischemia or denervation. Although this model requires a delay procedure, it allows the flap, that can be used as a free myocutaneous flap, to be raised reliably.Journal of Reconstructive Microsurgery 12/1995; 11(6):439-45. · 1.43 Impact Factor -
Article: Therapeutic drug monitoring of anti-tuberculous drugs.
Internal Medicine Journal 34(1-2):72-3. · 1.54 Impact Factor
