A J M Christina

Publications (13)15.95 Total impact

• Article: Wound healing activity of the leaves of Tribulus terrestris (linn) aqueous extract in rats

  J. John Wesley, A J M Christina, N Chidambaranathan, K. Ravikumar
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  ABSTRACT: The leaves of Tribulus terrestris(zygophyllaceae) are used traditionally in the folklore for the treatment of various kinds of wounds. The present study was undertaken to verify the effect of the leaves of T. terrestris on experimentally induced excision wound, incision wound and burn wound models in rats. Aloe vera was used as standard wound healing agent. A formulation of aqueous leaves extract in carbopol at 2.5% and 5% concentrations were prepared and applied to the wounds. In the excision and burn wound models, the animal showed significant reduction in period of epithelization and wound contraction (50%). In the incision wound model a significant increase in the breaking strength was observed. The results suggest that T. terrestris aqueous leaves extract applied topically possess wound healing activity.
  Journal of Pharmacy Research. 01/2009;
• Article: Antilithiatic Effect of Melia azedarach. on Ethylene Glycol–Induced Nephrolithiasis in Rats

  A.J.M. Christina, N.A. Haja Najumadeen, S. Vimal Kumar, N. Manikandan, G.C. Tobin, S. Venkataraman, N. Murugesh
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  ABSTRACT: The effect of the aqueous extract of Melia azedarach. Linn. (Meliaceae) against ethylene glycol–induced nephrolithiasis in male Wistar albino rats is summarized in this study. Lithiasis was induced in rats by administering 0.75% ethylene glycol in drinking water for 28 days and was manifested by high urinary calcium, phosphate, oxalate, and low urinary magnesium content. Simultaneous administration of aqueous extract of Melia azedarach. (AEMA; 250 mg/kg body weight) orally for 28 days along with ethylene glycol (0.75%) reduced urinary calcium, oxalate, phosphate, and elevated urinary magnesium level. It also increased the urine volume, thereby reducing the tendency for crystallization. The histopathological studies confirmed the induction of lithiasis as microcrystal deposition was observed in sections of kidney from animals treated with ethylene glycol. This was reduced, however, after treatment with the extract. These observations enable us to conclude that AEMA is effective against ethylene glycol–induced nephrolithiasis.
  10/2008; 44(6):480-485.
• Article: Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.?

  A J M Christina, G R Saraswathy, S J Heison Robert, R Kothai, N Chidambaranathan, G Nalini, R L Therasal
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  ABSTRACT: This study was carried out to evaluate the antifibrotic effect of ethanol extract of the fruits of Indian herb Piper longum Linn. Liver fibrosis was induced in rats by CCl(4) administration. The extent of liver fibrosis was assessed by measuring the level of liver hydroxy proline (HP) and serum enzyme levels. Following CCl(4) administration HP was significantly increased and serum enzyme levels were elevated. Treatment with the ethanol extract of Piper longum Linn. reduced the HP and also the serum enzymes. The liver weight that increased following CCl(4) administration due to the deposition of collagen was reduced by the ethanol extract. Hence, it is concluded that this extract inhibits liver fibrosis induced by CCl(4).
  Phytomedicine 03/2006; 13(3):196-8. · 3.27 Impact Factor
• Article: Antilithiatic effect of Asparagus racemosus Willd on ethylene glycol-induced lithiasis in male albino Wistar rats.

  A J M Christina, K Ashok, M Packialakshmi, G C Tobin, J Preethi, N Murugesh
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  ABSTRACT: The ethanolic extract of Asparagus racemosus Willd. was evaluated for its inhibitory potential on lithiasis (stone formation), induced by oral administration of 0.75% ethylene glycolated water to adult male albino Wistar rats for 28 days. The ionic chemistry of urine was altered by ethylene glycol, which elevated the urinary concentration of crucial ions viz. calcium, oxalate, and phosphate, thereby contributing to renal stone formation. The ethanolic extract, however, significantly (p < 0.05) reduced the elevated level of these ions in urine. Also, it elevated the urinary concentration of magnesium, which is considered as one of the inhibitors of crystallization. The high serum creatinine level observed in ethylene glycol-treated rats was also reduced, following treatment with the extract. The histopathological findings also showed signs of improvement after treatment with the extract. All these observations provided the basis for the conclusion that this plant extract inhibits stone formation induced by ethylene glycol treatment.
  Methods and Findings in Experimental and Clinical Pharmacology 11/2005; 27(9):633-8. · 0.93 Impact Factor
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  Available from: pjps.pk

  Article: Anti-inflammatory activity of Coldenia procumbens Linn.

  B Arul, R Kothai, K Sureshkumar, A J M Christina
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  ABSTRACT: Anti-inflammatory activity of the ethanolic extract of the aerial parts of Coldenia procumbens Linn. was studied in Wister rats using the carrageenan induced left hind paw edema, carrageenan induced pleurisy and cotton pellet induced granuloma model. The ethanolic extract (150 mg/kg, p.o.) produced the inhibition of carrageenan induced rat paw edema. It also showed an inhibitory effect on leukocyte migration and a reduction on the pleural exudates as well as reduction on the granuloma weight in the cotton pellet granuloma method. The results indicated that the ethanolic extract produced significant (P<0.001) anti-inflammatory activity when compared with the standard and untreated control.
  Pakistan journal of pharmaceutical sciences 07/2005; 18(3):17-20. · 1.10 Impact Factor
• Article: Hypoglycemic and antiperglycemic effects of Semecarpus anacardium linn in normal and alloxan-induced diabetic rats.

  R Kothai, B Arul, K Suresh Kumar, A J M Christina
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  ABSTRACT: The effect of ethanolic extract of dried nuts of Semecarpus anacardium on blood glucose level was investigated in both normal and alloxan induced diabetic rats. The blood glucose levels were measured at 0, 1, 2 and 3 hours after the treatment. The ethanolic extract of S. anacardium (100 mg/kg) reduced the blood glucose of normal rat from 84 +/- 1.4 to 67 +/- 1.7 mg/dl, 3 hours after oral administration of the extract (P < 0.05). It also significantly lowered blood glucose level in alloxan induced diabetic rat from 325 +/- 2.2 to 144 +/- 1.4 mg/dl, 3 hours after oral administration of the extract (P < 0.05). The antihyperglycemic activity of S. anacardium was compared with tolbutamide, an oral hypoglycemic agent.
  Journal of Herbal Pharmacotherapy 02/2005; 5(2):49-56.
• Article: Hypoglycemic and antihyperglycemic effect of Semecarpus anacardium Linn in normal and streptozotocin-induced diabetic rats.

  B Arul, R Kothai, A J M Christina
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  ABSTRACT: The effect of ethanolic extract of dried nuts of Semecarpus anacardium on blood glucose was investigated in both normal (hypoglycemic) and streptozotocin-induced diabetic (antihyperglycemic) rats. The blood glucose levels were measured at 0, 1, 2 and 3 h after the treatment. The ethanolic extract of S. anacardium (100 mg/kg) reduced the blood glucose of normal rats from 85.83 +/- 1.55 to 65.83 +/- 2.20 mg/dl, 3 h after oral administration of the extract (p < 0.05). It also significantly lowered blood glucose levels in streptozotocin-induced diabetic rats from 335.33 +/- 4.90 to 132.17 +/- 4.49 mg/dl, 3 h after oral administration of the extract (p < 0.05). The antihyperglycemic activity of S. anacardium was compared with tolbutamide, a sulfonyl urea derivative used in diabetes mellitus.
  Methods and Findings in Experimental and Clinical Pharmacology 01/2005; 26(10):759-62. · 0.93 Impact Factor
• Article: Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn.

  James B Perianayagam, S K Sharma, Aney Joseph, A J M Christina
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  ABSTRACT: The present study was designed to investigate the anti-pyretic and analgesic activity of ethanol (EEO) and aqueous (AEO) extracts of Emblica officinalis fruits in several experimental models. A single oral dose of EEO and AEO (500 mg/kg, i.p.) showed significant reduction in brewer's yeast induced hyperthermia in rats. EEO and AEO also elicited pronounced inhibitory effect on acetic acid-induced writhing response in mice in the analgesic test. Both, EEO and AEO did not show any significant analgesic activity in the tail-immersion test. These findings suggest that extracts of Emblica officinalis fruits possessed potent anti-pyretic and analgesic activity. Preliminary phytochemical screening of the extracts showed the presence of alkaloids, tannins, phenolic compounds, carbohydrates and amino acids, which may be responsible for anti-pyretic and analgesic activities.
  Journal of Ethnopharmacology 12/2004; 95(1):83-5. · 3.01 Impact Factor
• Article: Anticarcinogenic activity of Withania somnifera Dunal against Dalton's ascitic lymphoma.

  A J M Christina, D Gladwin Joseph, M Packialakshmi, R Kothai, S Jerry Heison Robert, N Chidambaranathan, M Ramasamy
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  ABSTRACT: The effect of ethanolic extract of the root of Withania somnifera Dunal (REWS) against Dalton's Ascitic Lymphoma has been evaluated in Swiss albino mice. A significant increase in the life span and a decrease in the cancer cell number and tumour weight were noted in the tumour-induced mice after treatment with REWS. The hematological parameters were also corrected by REWS in tumour-induced mice. These observations are suggestive of the protective effect of REWS in Dalton's Ascitic Lymphoma (DAL).
  Journal of Ethnopharmacology 09/2004; 93(2-3):359-61. · 3.01 Impact Factor
• Article: Effect of Indigofera aspalathoides against Dalton's ascitic lymphoma.

  A J M Christina, M Alwin Jose, S Jerry Heison Robert, R Kothai, N Chidambaranathan, P Muthumani
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  ABSTRACT: The effect of intraperitoneal injection of 400 mg/kg of ethanolic extract of Indigofera aspalathoides (EEIA) against Dalton's ascitic lymphoma has been evaluated in Swiss albino mice. A significant increase in the life span, a decrease in the cancer cell count and body weight were noted in the tumour-induced mice after treatment with EEIA. These observations indicate that the plant is having protective effect in Dalton's ascitic lymphoma.
  Fitoterapia 05/2003; 74(3):280-3. · 1.85 Impact Factor
• Article: Modulatory effect of Cyclea peltata Lam. on stone formation induced by ethylene glycol treatment in rats.

  A J M Christina, M Packia Lakshmi, M Nagarajan, S Kurian
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  ABSTRACT: The inhibitory effect of the root of Cyclea peltata Lam. on nephrolithiasis induced in rats by feeding with ethylene glycolated water (1%) for 35 days was summarized. Ethylene glycol administration led to oxalate stone formation, as indicated by its high level in urine. Complementary to this anion, the cation calcium level in urine was elevated. These two ions may have contributed to the formation of calcium oxalate stones. In addition to high serum potassium, a low serum magnesium level contributed to stone formation. Simultaneous administration of the powdered root of Cyclea peltata resulted in decreased urinary oxalate and calcium. Likewise, serum potassium was lowered and magnesium was elevated. These observations provided the basis for the conclusion that this plant inhibits the stone formation induced by ethylene glycol treatment.
  Methods and Findings in Experimental and Clinical Pharmacology 04/2002; 24(2):77-9. · 0.93 Impact Factor
• Article: Studies on the antilithic effect of Rotula aquatica lour in male Wistar rats.

  A J M Christina, M Priya Mole, P Moorthy
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  ABSTRACT: The decoction of Rotula aquatica lour was screened for antilithic activity in male Wistar rats and the results were summarized based on the ionic changes in both urine and serum. Nephrolithiasis was induced in rats by feeding them 3% glycolic acid mixed feed for 45 days, which resulted in high urinary calcium, oxalate and high serum potassium. Simultaneous treatment with the decoction reduced calcium and oxalate ion concentration in urine, confirming the stone inhibitory effect. Histopathological studies of kidney tissue samples further substantiated the findings. The decoction was found to be nontoxic over the 45-day treatment period.
  Methods and Findings in Experimental and Clinical Pharmacology 24(6):357-9. · 0.93 Impact Factor
• Article: Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn

  James B. Perianayagam, S.K. Sharma, Aney Joseph, A.J.M. Christina
  [show abstract] [hide abstract]
  ABSTRACT: The present study was designed to investigate the anti-pyretic and analgesic activity of ethanol (EEO) and aqueous (AEO) extracts of Emblica officinalis fruits in several experimental models. A single oral dose of EEO and AEO (500 mg/kg, i.p.) showed significant reduction in brewer’s yeast induced hyperthermia in rats. EEO and AEO also elicited pronounced inhibitory effect on acetic acid-induced writhing response in mice in the analgesic test. Both, EEO and AEO did not show any significant analgesic activity in the tail-immersion test. These findings suggest that extracts of Emblica officinalis fruits possessed potent anti-pyretic and analgesic activity. Preliminary phytochemical screening of the extracts showed the presence of alkaloids, tannins, phenolic compounds, carbohydrates and amino acids, which may be responsible for anti-pyretic and analgesic activities.
  Journal of Ethnopharmacology.