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ABSTRACT: We report the chest radiographic and CT findings in 21 immunocompromised patients with invasive pulmonary aspergillosis (IPA) and describe the outcome when the early diagnosis was linked to treatment with liposomal amphotericin B.
Chest radiographs and CT examinations were analyzed retrospectively in 53 consecutive neutropenic patients with suspected early IPA.
Twenty-one of 244 patients admitted for chemotherapy of hematologic malignancy fulfilled the definition for IPA - incidence of 8.6%. The incidence of normal and non-specific chest radiographic findings was high (29% and 71%, respectively) during the early stages of IPA. The CT halo sign was seen in 20 of the 21 patients (95%), and occurred within 5 days of neutropenic fever that was unresponsive to antibiotics in 5 patients. Crescent signs or cavitations were seen in 7 patients (33%). Treatment with liposomal amphotericin B was associated with an attributable mortality of 9.5%. Two patients died from IPA having a high fungal burden.
Early chest CT in neutropenic patients at risk for IPA is an important diagnostic and management tool and should be included in the investigative protocol even when chest radiographs are normal or non-specific.
Acta Radiologica 06/2002; 43(3):292-8. · 1.37 Impact Factor
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ABSTRACT: We compared 54 patients treated by a Medoff sliding plate (MSP) with 60 stabilised by a compression hip screw (CHS) in a prospective, randomised study of the management of intertrochanteric femoral fractures. Four months after the operation femoral shortening was determined from radiographs of both femora. In unstable fractures the mean femoral shortening was 15 mm with the MSP and 11 mm with the CHS (p = 0.03). A subgroup in which shortening was classified as large, comprising one-third of the patients in each group, had a similar extent of shortening, but more medialisation of the femoral shaft occurred in the CHS (26%) than in the MSP (12%) group (p = 0.03). Five postoperative failures of fixation occurred with the CHS and none with the MSP (p = 0.03). The marginally greater femoral shortening seen with the MSP compared with the CHS appeared to be justified by the improved control of impaction of the fracture. Biaxial dynamisation in unstable intertrochanteric fractures is a safe principle of treatment, which minimises the rate of postoperative failure of fixation.
Journal of Bone and Joint Surgery - British Volume 06/2001; 83(4):572-8. · 2.83 Impact Factor
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K Lunsjö,
L Ceder,
K G Thorngren,
B Skytting,
J Tidermark,
P O Berntson,
I Allvin,
S Norberg,
K Hjalmars,
S Larsson,
R Knebel, A Hauggaard,
L Stigsson
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ABSTRACT: We compared the efficacy of the Medoff sliding plate (MSP) with 3 other screw-plate systems for fixation of unstable intertrochanteric fractures in a randomized multicenter trial of 569 elderly patients. The MSP has biaxial dynamic capacity along both the neck and the shaft of the femur unlike the other systems, which lack dynamic capacity along the shaft. 268 fractures were operated on with the MSP, and 301 with the dynamic hip screw (DHS), with or without a trochanteric stabilizing plate (DHS/TSP) or with the dynamic condylar screw (DCS). The MSP had recently been shown to the surgeons. The patients in the groups were similar as regards age, domestic situation, preinjury walking ability and type of fracture. We followed the patients clinically and radiographically for at least 1 year. There was no significant difference in walking ability at follow-up or rate of return to home. Fixation failure occurred in 18/268 fractures operated on with the MSP, in 8/238 with the DHS, in 3/49 with the DHS/TSP and in 1/14 with the DCS. The difference in the rate of fixation failure was not statistically significant when the MSP group was compared to the 3 other groups. In 14 of the 18 fixation failures in the MSP group, the biaxial dynamic capacity of the MSP had not been used due to technical errors by surgeons, unfamiliar with the new method. No selection bias was found regarding fracture types in the 2 subgroups of patients with correct or inadequate biaxial dynamization. Extramedullary fixation of unstable intertrochanteric fractures with these implants showed a low failure rate. When using the MSP, biaxial dynamization must be correctly performed.
Acta Orthopaedica Scandinavica 05/2001; 72(2):133-40.
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ABSTRACT: The twin hook, which has 2 oppositely directed apical hooks, is an alternative to the lag screw for use with a 'dynamic plate' in the fixation of trochanteric hip fractures. In this prospective study lasting 1 year, 102 consecutive patients with trochanteric hip fractures were treated by 19 surgeons with either a twin hook or a lag screw combined with a conventional sliding hip screw plate or a Medoff sliding plate. Seven intraoperative errors were made with the twin hook but postoperative migration did not differ significantly between the 2 groups. Postoperative fixation failures were equally distributed between the 2 groups. The twin hook provides adequate fixation, which is comparable to that produced by a lag screw.
International Orthopaedics 02/2000; 24(5):249-55. · 2.03 Impact Factor
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K Lunsjö,
L Ceder,
J Tidermark,
P Hamberg,
B E Larsson,
B Ragnarsson,
R W Knebel,
I Allvin,
K Hjalmars,
S Norberg,
P Fornander, A Hauggaard,
L Stigsson
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ABSTRACT: We compared the efficacy of a load-sharing device, the Medoff sliding plate (MSP), with that of 3 other load-bearing screw-plate devices for the fixation of subtrochanteric fractures in a randomized multicenter trial of 107 elderly patients. 55 fractures were operated on with the MSP, and 52 with the dynamic hip screw (DHS) with or without a trochanteric stabilizing plate (TSP) or with the dynamic condylar screw (DCS). The patient material in the groups was similar regarding age, domestic situation, preinjury walking ability and fracture types. We followed the patients clinically and radiographically for a minimum of 1 year. There was no significant difference in walking ability or return rate to the home at follow-up. Fixation failure occurred in 1/55 fractures operated on with the MSP, in 3/32 with the DHS, in 3/12 with the DCS and in 2/8 with the DHS/TSR The difference in the rate of fixation failure was statistically significant, when the MSP group was compared to the 3 load-bearing devices in the other group (1 vs 8). On the basis of this experience, we think that the load-sharing principle of the MSP, which seems to facilitate fracture impaction and stability, appears to be a good alternative in extramedullary fixation of subtrochanteric fractures.
Acta Orthopaedica Scandinavica 11/1999; 70(5):459-66.
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ABSTRACT: Thirty-two consecutive subtrochanteric fractures in 32 patients were stabilized using the Medoff sliding plate and were followed up prospectively for 1 year. Two patients died during the first postoperative year. Twenty-nine of the remaining 30 (97%) fractures united by 1-year followup. Two types of plate dynamization schema were used: uniaxial (17 patients) and biaxial (15 patients). With uniaxial dynamization, plate sliding averaged 12 mm along the femoral shaft without medialization of the femoral shaft. With biaxial dynamization along the femoral shaft and the neck, plate sliding averaged 11 mm and screw in barrel sliding averaged 9 mm; medialization of the femoral shaft ranged from 0% to 35% of the femoral shaft diameter. Three fractures treated with uniaxial dynamization had migration of the lag screw within the femoral head; all three fractures united without additional screw migration after secondary or staged biaxial plate dynamization.
Clinical Orthopaedics and Related Research 03/1998; · 2.53 Impact Factor
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ABSTRACT: To find a practical method for estimating the degree of sliding that occurs in screw-plate devices used in hip-fracture surgery. Greater understanding of the sliding mechanisms in different fracture types should improve surgical technique and reduce the failure rate.
In dynamic screw-plate devices, the lag screw slides inside the barrel of the plate. A recent innovation allows the barrel-plate to slide inside a side-plate, thus making possible a combined fracture compression along the neck and the shaft of femur. The lengths of the different parts and the angle of a device in vivo, measured on a radiograph, depend on the position of the femur relative to the photographic film and the roentgen source. We obtained these measurements with a ruler and a protractor from sequential a.p. radiographs of the hip and implemented them in a special computerized program that used the principles of the scaled orthographic and the central projection models. These calculations provided the correct amount of sliding by the lag screw and by the barrel-plate within the side-plate.
The method presented here can establish the real degree of sliding in screw-plate devices from standard a.p. radiographs independently of the position of the hip.
Acta Radiologica 12/1997; 38(6):1057-62. · 1.37 Impact Factor
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ABSTRACT: In a prospective study, 94 consecutive patients with unstable intertrochanteric fractures were treated by 16 surgeons, using a modified 4-hole Medoff sliding plate and followed clinically and radiographically for 1 year. Weight bearing after surgery was allowed as tolerated. This new device is smaller and uses a simpler technique of insertion than the original 6-hole Medoff sliding plate. The modification of the plate makes biaxial sliding along both the shaft and the neck of the femur obligatory. All fractures united and no postoperative lag screw penetration occurred. The use of a shorter side-plate with 4 cortical bone screws was sufficient for fixation and no plate loosening or breakage was observed. On the basis of this experience, biaxial dynamization seems to facilitate fracture impaction and stability, and the simplified 4-hole Medoff sliding plate appears to be a suitable method for the treatment of unstable intertrochanteric fractures.
Acta Orthopaedica Scandinavica 09/1997; 68(4):327-31.
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A Hauggaard
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ABSTRACT: A case of adverse respiratory reaction to the i.v. injection of iohexol (300 mg I/ml, 131 ml in 4 min) in association with abdominal CT is described. The potentially pathogenetic mechanisms of pulmonary oedema induced by radiographic contrast media are discussed.
Acta Radiologica 10/1996; 37(5):823-5. · 1.37 Impact Factor
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ABSTRACT: The Medoff sliding plate (MSP) is a new device used to treat intertrochanteric and subtrochanteric fractures. There are three options for sliding; either along the shaft or the neck of the femur, or a combination of both. In a prospective series of 108 consecutive displaced intertrochanteric fractures we used combined dynamic compression. The patients were followed clinically and radiologically for one year. All fractures healed during the follow-up period. The only postoperative technical failure was one lag-screw penetration. Combined compression of the MSP gives increased dynamic capacity which reduces the risk of complications. The low rate of technical failure in our series compares favourably with that of the sliding hip screw or the Gamma nail but randomised trials comparing the MSP with other hip screw systems are necessary to find the true role of the MSP with its various sliding modes.
Journal of Bone and Joint Surgery - British Volume 06/1996; 78(3):387-90. · 2.83 Impact Factor
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ABSTRACT: This is an assessment of a new device for treatment of intertrochanteric and subtrochanteric fractures. The Medoff sliding plate (MSP) allows compression in 3 different modes: along the femoral shaft, along the femoral neck or a combination of both. In this prospective series of 104 consecutive intertrochanteric fractures, dynamic compression was allowed only along the femoral shaft. Simple undislocated intertrochanteric 2-part fractures were excluded. The patients were followed clinically and radiographically for 1 year. 21 patients died within 1 year after the operation. 7 technical failures including 2 non-unions occurred. All were lag screw penetrations, 4 of which were considered to be due to unforced errors by the surgeons. The technical failure rate in this preliminary evaluation of the MSP is similar to that of the dynamic hip screw. Randomized trials comparing the MSP with other hip screw systems should follow to ascertain possible advantages of the MSP, with its various sliding modes in different types of fractures of the proximal femur.
Acta Orthopaedica Scandinavica 09/1995; 66(4):343-6.
