A H M Moons

Publications (3)9.95 Total impact

• Article: The value of haemostatic markers in the triage of patients with chest pain presenting with a normal or non-diagnostic ECG.

  A H M Moons, P M van der Zee, R Bholasingh, A Sturk, C E Hack, J C M Meijers, O Kamp, J H Cornel, R J G Peters, R J de Winter
  Heart (British Cardiac Society) 10/2005; 91(9):1215-6. · 4.22 Impact Factor
• Article: Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin-10 response in human endotoxemia.

  A C J M de Pont, A H M Moons, E de Jonge, J C M Meijers, G P Vlasuk, W E Rote, H R Büller, T van der Poll, M Levi
  [show abstract] [hide abstract]
  ABSTRACT: The tissue factor-factor (F)VIIa complex (TF/FVIIa) is responsible for the initiation of blood coagulation under both physiological and pathological conditions. Recombinant nematode anticoagulant protein c2 (rNAPc2) is a potent inhibitor of TF/FVIIa, mechanistically distinct from tissue factor pathway inhibitor. The first aim of this study was to elucidate the pharmacokinetics and pharmacodynamics of a single intravenous (i.v.) dose of rNAPc2. The second aim was to study its effect on endotoxin-induced coagulation and inflammation. Initially, rNAPc2 was administered to healthy volunteers in three different doses. There were no safety concerns and the pharmacokinetics were consistent with previous studies, in which rNAPc2 was administered subcutaneously. rNAPc2 elicited a dose-dependent reduction of the endogenous thrombin potential and a selective prolongation of prothrombin time. Subsequently, the effect on endotoxin-induced coagulation and inflammation was studied. The administration of rNAPc2 completely blocked the endotoxin-induced thrombin generation, as measured by plasma prothrombin fragment F1+2. The endotoxin-induced effect on fibrinolytic parameters such as plasmin-antiplasmin complexes and plasminogen activator inhibitor type 1 was not affected by rNAPc2. The administration of rNAPc2 attenuated the endotoxin-induced rise in interleukin (IL)-10, without affecting the rise in other cytokines. In conclusion, rNAPc2 is a potent inhibitor of TF/FVIIa, which was well tolerated and could safely be used intravenously in this Phase I study in healthy male volunteers. A single i.v. dose rNAPc2 completely blocked endotoxin-induced thrombin generation without affecting the fibrinolytic response. In addition, rNAPc2 attenuated the endotoxin-induced rise in IL-10, without affecting the rises in other cytokines.
  Journal of Thrombosis and Haemostasis 02/2004; 2(1):65-70. · 5.73 Impact Factor
• Source

  Available from: nih.gov

  Article: Inhibition of the tissue factor pathway of coagulation by recombinant nematode anticoagulant protein c2 during elective coronary stent implantation

  A H M Moons, N R Bijsterveld, K T Koch, J.C.M. Meijers, J G P Tijssen, T van der Poll, H R Büller, R J G Peters