Akin Erdal

Ataturk University, Kalikala, Erzurum, Turkey

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Publications (26)39.04 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective: Recent studies suggest that endogenous melatonin (MLT) production might play a role in the etiology of rheumatoid arthritis (RA). However, the role of MLT in RA pathogenesis remains unclear. This study was performed to determine MLT serum levels in RA patients. Materials and Methods: Twenty nine patients with RA and in 25 age- and sex-matched healthy controls were included in our study. Blood samples of the participants collected at 8AM. MLT was measured by enzyme-linked immunosorbent assay (ELISA). The MLT levels of the patients with RA were compared with healthy age- and sex-matched controls. The Mann-Whitney U-test was used to compare the data between the two groups. Results: MLT concentrations were significantly higher in RA patients than in the controls (p<0.05). Conclusion: Our results suggest that the higher blood concentrations of MLT in RA patients, especially in the early morning, may help to explain the morning stiffness and joint swelling. Turk J Phys Med Rehab 2013;59:42-4.
    FTR - Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi 03/2013; 59(1):42-44. DOI:10.4274/tftr.26122 · 0.14 Impact Factor
  • T Baykal · K Senel · F Alp · A Erdal · M Ugur ·
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    ABSTRACT: Background: Recently, it has been recognized that vitamin D not only is important for calcium metabolism and maintenance of bone healthy, but also plays an important role in reducing risk of many chronic diseases including rheumatoid arthritis (RA), systemic lupus erythematosus, insulin-dependent diabetes mellitus, multiple sclerosis, several cancers, heart and infectious diseases. In RA, the role of vitamin D is undefined. Methods: The objective of this present study was to determine serum 25-hydroxyvitamin D (25(OH)D) concentrations in patients with RA and to establish its correlation with disease activity. This study was performed on fifty-five consecutive patients RA fulfilling the American Collage of Rheumatology (ACR) criteria for the classification of RA and forty-five healthy subjects. Serum 25(OH)D levels were measured using Elecsys 25(OH)D reactive kit. Disease activity was assessed according to DAS28, the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). The association between serum levels of 25(OH)D and age, gender, disease duration and disease activity parameters were established. Results: The mean serum 25(OH)D levels were significantly decreased in RA patients compared to healthy controls (p < 0.01) and were associated with higher levels of parathyroid hormone. Vitamin D deficiency (i.e. < 30 ng/ml) was found in 50 patients (90.9 %). Serum levels of vitamin D lower than 20 ng/ml were found in 72 % of patients. We did not find the correlation between serum 25(OH)D levels and disease activity parameters. Conclusions: Our findings have demonstrated that serum 25(OH)D levels is highly prevalent in patient with RA. We believe that it will be helpful to investigate the vitamin D levels in order to determine the osteomalacia risk of RA patients (Tab. 2, Ref. 11).
    Bratislavske lekarske listy 10/2012; 113(10):610-1. DOI:10.4149/BLL_2012_137 · 0.44 Impact Factor
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    ABSTRACT: Brucellosis is a zoonotic disease and still a major public health problem in many geographic areas including Mediterranean basin and Middle East. Brucellosis causes multisystemic involvement and although rare central nervous system involvement causes serious manifestations. Neurobrucellosis occurs less than 5% of patients and presents with meningitis,encephalitis, myelitis, myelopathy, stroke, paraplegia, radiculoneuritis, intracerebral abscess, epidural abscess, demyelination and cranial nerve involvement or any combination of these manifestations. Spastic paraparesis and the sensorineural involvement are rarely reported in the literature. Herein we present a 28 years-old man with spastic paraparesis and sensorineural hearing loss due to neurobrucellosis. The patient was treated with antibiotics combination for 6 months and underwent rehabilitation program. Neurobrucellosis should be ruled out in patients with unexplained neurological symptoms and/or sensorineuralhearing loss particularly in those living in endemic areas.
    Journal of Back and Musculoskeletal Rehabilitation 10/2012; 25(3):157-9. · 0.71 Impact Factor
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    ABSTRACT: OBJECTIVES: The aim of this study was to assess the point prevalences of hay fever, asthma, and atopic dermatitis in OA, RA, and AS, and to compare with healthy controls. METHODS: A total of 935 patients and healthy controls were included. Demographic and clinical features were recorded, and a questionnaire assessing the existence of atopic disorders like asthma, hay fever, and atopic dermatitis in all groups was applied. "Either atopy" implied that an individual was either diagnosed with or had symptoms of one or more of these disorders, such as asthma, hay fever, or atopic dermatitis. RESULTS: When compared to the controls, only patients with AS had an increased risk for hay fever (OR 1.52, 95 % CI 1.00-2.41). Patients with RA had increased risks for hay fever, atopic dermatitis, and either atopy compared to the patients with OA (2.14, 95 % CI 1.18-3.89; 1.77, 95 % CI 1.00-3.18; and 3.45, 95 % CI 1.10-10.87, respectively). Steroid use had no effect on the prevalence of atopic disorders in patients with RA. CONCLUSIONS: Patients with OA, RA, and AS seem to have similar risks for asthma, atopic dermatitis, and either atopy to healthy controls. However, the prevalence of hay fever may increase in AS. Patients with RA have a higher risk of atopy than patients with OA.
    Modern Rheumatology 05/2012; 23(2). DOI:10.1007/s10165-012-0653-6 · 2.40 Impact Factor
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    ABSTRACT: The fibromyalgia syndrome (FMS) is a chronic, widespread pain disorder of unknown etiology. It has been suggest that familial component, environmental factors, endocrine and neurotransmitter alterations, and psychological factors may contribute to the development of FMS. The role of melatonin in FMS is unclear. Some studies describe a lower nocturnal peak and a decreased secretion of melatonin in women with FMS when compared with healthy matched controls. The aim of the present study was to determine the possible role of melatonin in FMS patients. We examined the characteristics and levels of melatonin in 25 consecutive premenopausal women with FMS. Serum blood samples were collected from 25 patients and 20 the age and gender matched healthy controls. Melatonin levels were measured by enzyme-linked immunosorbent assay. Then, the results were compared with those from healthy subjects. Serum melatonin levels of FMS patients were not statistically different from those of controls (P > 0.05). No association was observed between melatonin levels of patients with FMS and disease duration, sleep disturbances, fatigue, and pain scores. Our results demonstrate that melatonin levels were similar in patients with FMS and healthy controls. Further studies are needed to determine the possible role of melatonin.
    Rheumatology International 12/2011; 33(6). DOI:10.1007/s00296-011-2315-y · 1.52 Impact Factor
  • W. Conca · S. Al-Salam · H. J. Ding · A. A. Mohd Thabit · H. Hussein · A. Koc · A. G. Karatepe · R. Gunaydin · T. Kaya · Y.-H. Lee · [...] · M. Nawata · H. Nagasawa · E. Satoh · K. Saito · Y. Kaneko · S. Fukuyo · T. Kurasawa · K. Hanami · H. Kameda · H. Yamanaka ·

    Rheumatology 02/2011; 50(Supplement 2):ii6-ii14. DOI:10.1093/rheumatology/ker097 · 4.48 Impact Factor
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    ABSTRACT: Rheumatoid arthritis (RA) is a chronic and disabling disease frequently effects physical and psychological well being. The aim of the present study was to determine the impact of psychological status on health related quality of life in patients with RA and also to assess which quality of life (QoL) instrument - disease specific and generic - is more prone to this effect. A total of 421 patients with RA recruited from joint database of five tertiary centers. Depression and anxiety risks were assessed by the Hospital Anxiety and Depression Scale (HADS); and quality of life assessed by Rheumatoid Arthritis Quality of Life (RAQoL), Nottingham Health Profile (NHP) and The Short Form 36 (SF 36) questionnaire. Patients with higher risk for depression or anxiety had poorer quality of life compared to the patients without risk for depression or anxiety. Depression and anxiety scores significantly correlated with quality of life questionnaires. There was significant association between anxiety and depression with worsening in both disease specific and generic health related quality of life. However, RAQoL showed more association with depression and anxiety levels. Higher depression and anxiety risks showed increased deterioration in quality of life. Compared to generic QoL scales, RAQoL scale, a disease specific QoL instrument, is much more influenced by depression and anxiety.
    Journal of Back and Musculoskeletal Rehabilitation 01/2011; 24(2):95-100. DOI:10.3233/BMR-2011-0281 · 0.71 Impact Factor
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    ABSTRACT: The aim of this study was to investigate the indicative value of the patient-reported outcome instruments (PROs) on disease activity in rheumatoid arthritis (RA). Three hundred sixty eight patients with RA were included in this cross-sectional study. Disease activity was evaluated using both the Disease Activity Score 28 (DAS 28) and the Clinical Disease Activity Index (CDAI). Patients who had DAS 28 score < 3.60 points and CDAI score <10.00 points were allocated into the "low disease activity" group and those who had DAS 28 score > or = 3.60 points and CDAI score > or = 10.00 points into the "moderate or high disease activity" group. The Health Assessment Questionnaire (HAQ), Nottingham Health Profile (NHP), Rheumatoid Arthritis Quality of Life (RAQoL), and Short Form 36 (SF 36) were used as PROs. Logistic regression analysis was used to find variables, which had an indicative value for disease activity. HAQ, pain and emotional reaction subscales of NHP, and bodily pain, general health and social functioning subscales of SF 36 had independent indicative values, when DAS 28 was used as dependent variable. On the other hand, HAQ, pain and emotional reaction subscales of NHP, and general health and emotional role limitation subscales of SF 36 had indicative values when CDAI was used as dependent variable. DAS 28 and CDAI both showed HAQ as the parameter with the highest odds ratio (OR). But RAQoL had shown no independent indicative value for projecting disease activity. It was concluded that HAQ could determine disease activity in RA better than other PROs included in this study (Tab. 4, Ref. 36).
    Bratislavske lekarske listy 01/2011; 112(10):555-61. · 0.44 Impact Factor
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    ABSTRACT: To investigate discrimination ability of the Assessment of Spondyloarthritis International Society (ASAS) endorsed disease activity score (ASDAS) versions evaluating low and high disease activity in an unselected group of patients with ankylosing spondylitis (AS). Patients consecutively included into the joint database of five university hospitals were analyzed for low or high disease activity according to different criteria. Standardized mean differences (SMD) for two ASDAS versions were evaluated. The ASDAS versions (back pain, morning stiffness, patient global pain, pain/swelling of peripheral joints, plus either erythrocyte sedimentation rate or C-reactive protein) discriminated high and low disease activity in subgroups according to Bath Ankylosing Spondylitis Disease Activity Score (BASDAI) and ASAS remission/partial remission criteria. ASDAS versions were also not influenced by peripheral arthritis and correlated well with other outcome measurements and acute-phase reactants. The ASDAS versions performed better than patient-reported measures or acute-phase reactants discriminating high and low disease activity status. Both ASDAS versions, consisting of both patient-reported data and acute-phase reactants, performed well in discriminating low and high disease activity. Further longitudinal data may better estimate the usefulness of ASDAS to assess disease activity subgroups and treatment response.
    International Journal of Rheumatic Diseases 08/2010; 13(3):240-5. DOI:10.1111/j.1756-185X.2010.01537.x · 1.47 Impact Factor
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    ABSTRACT: Familial Mediterranean fever (FMF) is an autosomal, recessively inherited multisystem disease that affects various groups of people originating from the Mediterranean Sea region, most specifically those of Jewish, Turkish, Armenian, and Arabic ethnicity. Recurrent attacks of fever and sterile polyserositis of the peritoneum, synovial membranes, and pleura are the main clinical features, although the clinical features of FMF have been expanded in recent years to also include severe myalgia, scrotal swelling, cardiac involvement, and protracted febrile myalgia syndrome (PFMS). PFMS is seen in only a small percentage of FMF patients and is characterized by severe debilitating myalgia of the upper and lower extremities and high fever, occasionally accompanied by abdominal pain, diarrhea, arthritis/arthralgia, and transient vasculitic purpura mimicking Henoch-Schönlein purpura (HSP). Here, we report on a patient with FMF who also presents with PFMS, which is an uncommon and severe manifestation of the disease.
    Modern Rheumatology 03/2010; 20(4):410-2. DOI:10.1007/s10165-010-0288-4 · 2.40 Impact Factor
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    ABSTRACT: This study investigated the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in familial Mediterranean fever (FMF) patients and controls. Forty-nine patients with FMF were enrolled (23 had a history of arthritis during attacks and 26 had no such history). Two control groups were enrolled: 20 patients with rheumatoid arthritis (RA) and 30 healthy individuals. Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), rheumatoid factor (RF), and anti-CCP antibody levels were measured. In RA patients' ESR and CRP levels, frequency of RF, and anti-CCP antibody levels were significantly higher than in both FMF patients and healthy controls (p 0.001). Moreover, anti-CCP was negative in all healthy controls as well as in all FMF patients. Our results show that anti-CCP antibodies are not associated with FMF.
    Journal of Back and Musculoskeletal Rehabilitation 01/2010; 23(1):21-3. DOI:10.3233/BMR-2010-0243 · 0.71 Impact Factor

  • Revue du Rhumatisme 12/2009; 76(12):1368-1370. DOI:10.1016/j.rhum.2009.07.005
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    ABSTRACT: To assess the frequency of juvenile onset ankylosing spondylitis (JOAS) in Turkish patients with AS and to compare with adult onset AS (AOAS) in a cross-sectional study design. A total of 322 patients were recruited from the joint database of 5 university hospitals in eastern Turkey. Patients with JOAS (n = 43, 13.4%) had significantly longer diagnostic delay (9.21 vs 5.08 yrs), less severe axial involvement and more prevalent uveitis (OR 2.92, 95% CI 1.25-6.79), and peripheral involvement at onset (OR 3.25, 95% CI 1.51-6.98, adjusted for current age; and OR 2.26, 95% CI 1.07-4.76, adjusted for disease duration). Patients with AOAS had higher radiographic scores and more restricted clinimetrics but similar functional limitations and quality of life. JOAS and AOAS had distinctive courses and Turkish patients with AS had similar features compared to other Caucasian patient populations.
    The Journal of Rheumatology 11/2009; 36(12):2830-3. DOI:10.3899/jrheum.090435 · 3.19 Impact Factor
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    ABSTRACT: This study was carried out to determine the serum levels of melatonin (MLT) in patients with ankylosing spondilitis (AS) and to evaluate its correlation with disease activity. We assessed clinical characteristics and labaratory parameters. Serum samples from 36 patients (25 males, 11 females) with active AS and 25 healthy subjects (18 males, 7 females) were collected. MLT levels were measured by enzyme-linked immunosorbent assay, and disease activity of AS was assessed according to the Bath AS disease activity index (BASDAI), the erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Then, the results were compared with those from 25 healty controls. The serum levels of MLT were significantly increased in AS patients as compared to healthy controls (p < 0.05). MLT levels were correlated with BASDAI (r = 0.871, p < 0.001) and CRP levels (r = 0.691, p < 0.001), but not with ESR, in patients with AS. Our results suggest a possible role for this immunoregulatory hormone in the disease activity in AS patients.
    Rheumatology International 10/2009; 31(1):61-3. DOI:10.1007/s00296-009-1223-x · 1.52 Impact Factor

  • Joint, bone, spine: revue du rhumatisme 08/2009; 76(6):719-21. DOI:10.1016/j.jbspin.2009.02.008 · 2.90 Impact Factor
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    ABSTRACT: The purpose of this, open-label, non-comparative study, was to evaluate the efficacy on quality of life and the efficacy of gabapentin monotherapy in patients with chronic radiculopathy. Thirty-five patients with radicular pain and diagnosed as L4, L5 or S1 radiculopathy were treated with oral gabapentin from a total of 300 mg per day once up to a total of 1800 mg per day divided in 3 doses for eight-week trial period. Quality of life, functional disability and psychological mood of the patients were assessed using the Nottingham Healthy Profile (NHP), Oswestry Low Back Pain Disability Questionnaire (ODQ) and Beck Depression Inventory (BDI). Of the patients (n = 35), 25 were females and 10 were males (mean age: 41.8 +/- 10.4, range: 24-60 years); mean radiculopathy duration was 16.4 +/- 14.2 months (range: 3-48 months). The pain intensity at rest, quality of life, functional disability and depression scores were determined significantly improved after treatment and 4 months compared to baseline scores (p < 0.001). 1.5 points compared to baseline for at pain rest and 15 points improvement on the ODQ were obtained. Gabapentin may provide benefits in terms of alleviation of pain and overall quality of life in patients with chronic radiculopathy.
    Journal of Back and Musculoskeletal Rehabilitation 01/2009; 22(1):17-20. DOI:10.3233/BMR-2009-0210 · 0.71 Impact Factor
  • M Ugur · K Yildirim · A Kiziltunc · A Erdal · S Karatay · K Senel ·
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    ABSTRACT: We investigated serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and the activity of extracellular superoxide dismutase (EC-SOD) in rheumatoid arthritis (RA). We also considered whether there was a correlation between sICAM-1 and EC-SOD and disease activity. Levels of sICAM-1 were measured in serum from 42 patients with active RA and 30 control subjects by enzyme-linked immunosorbent assay (ELISA). EC-SOD activity was determined in sera isolated from patients with active RA and from controls. The serum levels of sICAM-1 were significantly higher in patients with RA than in control subjects (p<0.001). In contrast, the activity of EC-SOD was significantly lower in RA patients than in healthy controls (p<0.001). A significant negative correlation was found between the levels of sICAM-1 and EC-SOD activity (r=-0.39, p<0.01). There was a statistically positive correlation between sICAM-1 levels with Ritchie articular index (RAI) score and C-reactive protein (CRP) (r=0.32, p<0.05; r=0.44, p<0.01, respectively). These results show that the increased levels of sICAM-1 present in active RA patients might be due to the decreased activity of EC-SOD, and increased levels of sICAM-1 may also reflect disease status or activity.
    Scandinavian Journal of Rheumatology 07/2004; 33(4):239-43. DOI:10.1080/03009740310004054 · 2.53 Impact Factor
  • Akin Erdal · Mahir Uğur · Seyithan Taysi · Kazim Şenel ·
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    ABSTRACT: This study was carried out to determine the serum levels of soluble intercellular adhesion molecule 1 (ICAM-1), nitric oxide and xanthine oxidase in patients with rheumatoid arthritis (RA) and to investigate the correlations between ICAM-1 and nitric oxide and xanthine oxidase. Serum samples were obtained from 42 patients with active RA and 30 healthy controls. ICAM-1, nitric oxide and xanthine oxidase levels were determined. ICAM-1, nitric oxide and xanthine oxidase levels were significantly elevated in patients with RA (p < 0.001). We found a significant positive correlation between ICAM-1 and nitric oxide (r = 0.426, p < 0.05). There was also a significant positive correlation between ICAM-1 and xanthine oxidase (r = 0.511, p < 0.01). High serum levels of soluble ICAM-1 may be a consequence of inflammation or tissue damage induced by nitric oxide generated by xanthine oxidase.
    The Pain Clinic 06/2004; 16(2):181-185. DOI:10.1163/156856904774134398
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    ABSTRACT: The aims of this study were to investigate a possible relationship between the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and some acute phase reactant (APR) levels in patients with ankylosing spondylitis (AS). Twenty outpatients who fulfilled the modified New York criteria for AS were included in the study. Laboratory activity was assessed by examining erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), haptoglobin (Hp), and beta2 microglobulin (beta2MG). Disease activity was assessed according to the BASDAI, which includes a 10-point visual analogue scale to measure pain, fatigue, morning stiffness, swelling, and areas of local tenderness. When APR values were analyzed for the BASDAI, a positive correlation between CRP and BASDAI was observed (r = 0.556, P < 0.05). There was no clear, statistically significant correlation between BASDAI and the other APRs (ESR, r = 0.328, P > 0.05; Hp, r = 0.035, P > 0.05; and beta2MG, r = -0.190, P > 0.05). Our data suggest that CRP is a better marker of disease activity than ESR, Hp, and beta2MG.
    Southern Medical Journal 04/2004; 97(4):350-3. DOI:10.1097/01.SMJ.0000066946.56322.3C · 0.93 Impact Factor
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    ABSTRACT: This study was carried out to determine the efficacy of gabapentin in patients with radiculopathy. Fifty patients (32 women, 18 men) with lumbosciatalgia secondary to L5 or S1 radiculopathy were evaluated. MRI showed L4-5 and/or L5-S1 bulging and/or protrusion without significant spinal stenosis. Baseline assessments for each patient included a standard neurological examination and radiological investigation. The patients were randomly assigned into two groups: group 1 was treated with oral gabapentin from a total of 900 mg per day up a total of 3600 mg per day divided in 3 doses; group 2 received placebo for the 8-week trial period. In group 1 we observed statistically significant improvement in pain at rest (p < 0.001), motor function (p < 0.01), limitation of spinal flexion (p < 0.001), straight leg raising test (p < 0.001) and sensory function (p < 0.001). Stretch reflexes instead did not significantly change. In group 2 we observed significant improvement in all clinical parameters, muscle strength and stretch reflexes excluded. The results of group 1 were significantly better than those of group 2.
    The Pain Clinic 08/2003; 15(3):213-218. DOI:10.1163/156856903767650718

Publication Stats

206 Citations
39.04 Total Impact Points


  • 2009-2013
    • Ataturk University
      • Faculty of Medicine
      Kalikala, Erzurum, Turkey
  • 2002-2004
    • Yuzuncu Yil University
      • Faculty of Medicine
      Thospia, Van, Turkey