[Show abstract][Hide abstract] ABSTRACT: In the most developed countries, laparoscopic diagnostics and surgical procedures in the chosen cases still play a very important role and represent the acceptable alternative to the extrauterine fertilization. On the basis of histopathological verification of ovary biopsy cuts taken during the laparoscopy, the optimum conditions are fulfilled for determination of the ovary potentiality enabling the selection of patients for the further proper treatment. 113 patients that, due to the marriage infertility, were examined and treated at the Department of Sterility and infertility of the Obstetrics and Gynecology Clinic, Clinical Center of Nis, with the average age of 31.39 +/- 6.10 and with the average marriage infertility period lasting from 4.11 +/- 2.99 had undergone the surgical laparoscopy. The most frequently used interventions that were performed, disregarding the adnexial findings, were salipongovariolyses in 73 cases (64.60%), then fimbrioplastic in 60 cases (53.10%). Ovary biopsy and histopathological analysis of the cuts taken were performed in 110 patients (89.39%). We got 105 histopathological findings. The most common histopathological findings showed the existence of the primordial folicules in 39.60% of women, with the prevalence in younger ones. (In patients younger than 20--66.67%, while in patients over 40--25%). We found out that the prevailing number of women had the histological findings that spoke on behalf of the potential ovaries in case the infertility lasted shorter. The ovary tissue cuts taken by biopsy that were histopathologically analyzed, showed the significantly higher pregnancy and delivery rate in findings with the primordial folicules present (67.5% of the pregnancy rate 57.5% of the intrauterine pregnancy rate and 47.5% of the delivery rate).
Srpski arhiv za celokupno lekarstvo 01/2003; 131(9-10):389-95. · 0.23 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Dysgerminoma is best known as the ovarian counterpart of seminoma of the testis Relatively uncommon tumors, dysgerminomas account for less than 2% of all ovarian cancer. We report a case of a 14 years old girl with a large and rapidly growing unilaleral ovarian dysgerminoma. Examination of the surgical specimen showed a tumor of 27x17x8 cm in size and 4800 gr. in weight. It was oval in shape with a slightly glistening fibrous capsule, soft but solid and hemorrhagic. The mass arose from the right ovary and did not invade any surrounding structures. The tumor and the ovary were torqued with its fallopian tube. Microscopic examination showed typical characteristics of ovarian dysgerminoma, with a micrometastasis in the omentum (in the vicinity of the tumor). The patient underwent a right salpingo-oophorectomy, had an uncomplicated postoperative course and received radio and chemotherapy Thirty months after the operation, the patient is in good health and with normal ultrasound and laboratory results. We believe that conservative surgery followed by adjuvant radiotherapy and chemotherapy seems to be ideal treatment in case of pure ovarian dysgerminoma when careful surgical staging confirmed the unilaterality of disease.