Publications (1)0 Total impact
Article: [Expression of proline-rich tyrosine kinase-2 in human primary colorectal carcinoma and its prognostic implication].[show abstract] [hide abstract]
ABSTRACT: To investigate the expression of proline-rich tyrosine kinase-2 (Pyk2) in human primary colorectal carcinoma (CRC) and it's prognostic significance. The expression of Pyk2 was retrospectively examined with immunohistochemistry (IHC) in 108 tissues of primary CRC. The correlation of Pyk2 expression to prognosis and relevant clinical factors were analyzed. The rate of Pyk2 low-expression in CRC was 56.5% (61/108). The expression of Pyk2 correlated significantly to the histological grade (P < 0.05) and the TNM stage (P < 0.05), while no correlation between Pyk2 expression and age, tumor size (P > 0.05). Patients with Pyk2 over-expression had significantly higher 5-year survival rate (66.0%) than those with Pyk2 low-expression (31.4%). Pyk2 expression, together with carcinoma histologic grade and TNM stage were prognostic factors to CRC on the multivariate analysis. Pyk2 expression can be a prognostic factor to the CRC patients together with other predictors.Zhonghua wai ke za zhi [Chinese journal of surgery] 04/2008; 46(6):440-2.