Zahra Saidani

Publications (2)1.28 Total impact

• Article: Devant cet impuberisme quels sont vos diagnostics?

  Walid Denguezli, Zina Chouket, Raja Faleh, Anis Haddad, Zahra Saidani, Hayet Laajili, Mohamed Sakouhi
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  ABSTRACT: Les auteurs rapportent un tableau clinique atypique, celui d’un patient présentant un désordre du développement sexuel (46XY DDS). L’exploration a montré des taux de FSH et LH élevés, une testostéronémie basse, avec absence de gonades ainsi que tout dérivé des canaux de Müller et de Wolff à la laparoscopie. Les auteurs discutent les différentes possibilités diagnostiques pouvant correspondre à ce tableau clinique et insistent sur celui de syndrome de régression testiculaire embryonnaire, entité rare et originale. The authors report a case of a 16-year-old Tunisian phenotypically female patient with an 46, XY karyotype. Serum assays showed high serum FSH and LH levels and low serum testosterone levels. Laparoscopic exploration was performed to distinguish between testicular feminization syndrome and gonadal dysgenesis. No gonads and no persistent Müllerian or Wolffian ducts were found. The authors suspected the diagnosis of embryonic testicular regression syndrome (TRS), a congenital condition in which the testes disappear during early embryonic development. A spectrum of pathological findings may be present, but few systematic descriptions have been reported in the literature. The authors describe a new case of suspected embryonic testicular regression syndrome and discuss the differential diagnoses.
  Andrologie 04/2012; 17(2):179-182.
• Article: Efficacy and safety of six hourly vaginal misoprostol versus intracervical dinoprostone: a randomized controlled trial.

  Walid Denguezli, Adnene Trimech, Anis Haddad, Awatef Hajjaji, Zahra Saidani, Raja Faleh, Mohamed Sakouhi
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  ABSTRACT: To compare the efficacy and safety of intravaginal misoprostol versus dinoprostone cervical gel for cervical ripening and labour induction. We carried out an experimental clinical trial in which we enrolled 130 cervical consecutive patients with cervical ripening, randomly assigned to one of the following two treatment groups: (1) intravaginal misoprostol and (2) intracervical dinoprostone gel. A total of 50 microm of misoprostol was placed in the posterior vaginal fornix every 6 h for a maximum period of 24 h and 0.5 mg of dinoprostone was administrated in the uterine cervix every 6 h, for a maximum period of 24 h. The primary outcome measure was the number (rate) of women who went to vaginally deliver within 24 h of the protocol initiation. Among 130 patients evaluated, 65 were allocated to the misoprostol group and 65 to the dinoprostone group. The proportion of vaginal delivery within 24 h was significantly higher in the misoprostol group (75%) than in the dinoprostone group (53.8%) (RR = 1.40, 95% CI [1.07-1.45], P = 0.02). There was no significant difference between the mean time interval of delivery in the misoprostol group and the dinoprostone group (14.9 vs.15.8 h) (P = 0.51). The Bishop score was significantly higher in the misoprostol group, 6 h after the onset of the study (1.38; relative risk, 95% CI [1.02-1.85], P = 0.03). The Caesarean delivery rate for fetal distress was higher in the dinoprostone group (21 vs. 10.8%, P = 0.15). The tachysystole (Misoprostol 6.1% vs. dinoprostone 4.6%, relative risk 1.15, 95% CI [0.6-2.24]) and hyperstimulation syndrome rates (Misoprostol 7.6% vs. dinoprostone 4.6%, relative risk 1.26, 95% CI [0.72-2.24]) were slightly increased in the misoprostol group than in the dinoprostone group without reaching the level of statistical signification. Misoprostol as used in this protocol is more effective than cervical dinoprostone gel application in the cervical ripening and labour induction. There is a tendency for an increase in the rate of tachysystole and hyperstimulation syndrome.
  Archives of Gynecology and Obstetrics 09/2007; 276(2):119-24. · 1.28 Impact Factor