Z. Khaksar

Shiraz University, Chimaz, Fārs, Iran

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Publications (6)1.18 Total impact

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    ABSTRACT: Otostegia persica extract was used as a traditional medicine for the management of diabetes mellitus in humans in some parts of Iran. This study investigated the effects of O. persica oral extract on pancreatic beta cells in streptozotocin-induced diabetic rats by stereological methods. Thirty-two matured normoglycemic male Sprague–Dawley rats, weighing 180–220 g, were selected and randomly divided into four groups: Control group consists of normal rats which did not receive the extract during the study. Diabetic group comprises diabetic rats but did not receive any extract. Treated control group rats were normal but received the extract at a dose of 500 mg/kg/day. Treated diabetic group (TD) was made up of diabetic rats and received the extract (500 mg/kg/day). Diabetes was induced by a single intraperitoneal injection of 50 mg/kg of streptozotocin. After 1 month, all the rats received deep anesthesia with ether, and then, the pancreas was dissected and processed. Isotropic uniform and random sections were obtained by orientator method. Volume of pancreatic beta cells and also volume density of pancreatic island were studied, using stereologic and ultrastereological methods. Blood glucose level (BGL) and blood insulin level (BIL) were measured in different phases during the investigation. Statistical analysis by one-way analysis of variance test showed the presence of hypertrophic changes in the volume of the remaining beta cells in diabetic group, not in the controls. But such changes reduced significantly (P < 0.05) in the TD group which received the extract. Also, a significant reduction in pancreatic islet volume in diabetic and TD groups was seen, in comparison with the controls (P < 0.01). BGL decreased significantly in TD group, compared to the diabetic group (P < 0.001). BIL decreased in diabetic and TD groups in comparison to the controls (P < 0.05). This study demonstrated that O. persica oral extract can play an effective role in the management of diabetes and probably by controlling the hyperglycemic condition and not stimulating the beta cell to increase insulin secretion can help prevent to a large extent the entering of the remaining beta cells to some pathologic changes, like hypertrophy.
    Comparative Clinical Pathology 05/2013; 23(3). DOI:10.1007/s00580-013-1682-z
  • S. Gholami, S. R. Ghazi, Z. Khaksar
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    ABSTRACT: Gholami, S., Ghazi, S.R. and Khaksar, Z. 1996. Postnatal changes of termination of spinal cord in camel (Camelus dromedarius). J. Appl. Anim. Res., 11: 69–72.
    Journal of Applied Animal Research 11/2011; 11(1):69-72. DOI:10.1080/09712119.1997.9706162 · 0.48 Impact Factor
  • Z Khaksar, G Jelodar, H Hematian
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    ABSTRACT: Introduction: In pregnant mothers, maternal diabetes occurs when pancreas can't produce enough insulin resulting in increased blood glucose levels in the mother and subsequently in the fetus. This investigation was conducted to evaluate the effects of maternal diabetes on cerebellum of offspring of diabetic mothers (ODM), which was carried out at the veterinary faculty of Shiraz University in 2007-2008. Methods: This was an experimental study that included sixteen normal adult female rats divided in two groups. Diabetes was induced in one group by Alloxan agent. Both groups became pregnant by natural mating . At 7, 14, 21 and 28 days after birth, the cerebellum of all offsprings were collected and the weight of neonates was also measured. After producing histological slides, Olympus BX51 microscope and ‍‍‍‍‍‍‍ Olysia softwarwere used. Various histological parameters used included gray and white matters thicknesses (µ), the number of cells in gray and white matter separately per unit and the ratio of gray matter to white matter. Results: Cerebellar parameters decreased in ODM as compared to the control group. The body weight of ODM was significantly more than that of the control group (p< 0.05). Conclusions: Maternal hyperglycaemia exhibited deleterious effects on cerebellum during fetal life, which remained persistent during postneonatal period. Maternal diabetes also resulted in reduction of number of cells and thicknesses of both gray and white matter.
  • 12/2009; 4(12):1227-1229. DOI:10.3923/rjbsci.2009.1227.1229
  • S. Jafari, S. N. S. Gaur, Z. Khaksar
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    ABSTRACT: Jafari, S., Gaur S.N.S. and Khaksar, Z. 1996. Prevalence of Dirofilaria immitis in dogs of Fars province of Iran. J. Appl. Anim. Res., 9: 27–31.The study was carried out for one year to observe the prevalence of Dirofilaria immitis in dogs of Fars province of Iran. Out of a total of 114 dogs examined, 11(9.65%) were found positive for this infection. The native Iranian dogs showed highest (18.5%) infection. There was no difference in the susceptibility to this infection, in long and short-haired animals.
    Journal of Applied Animal Research 03/1996; 9(1):27-31. DOI:10.1080/09712119.1996.9706101 · 0.48 Impact Factor
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    Z Khaksar, G A Jelodar
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    ABSTRACT: This study was conducted to evaluate the effects of maternal diabetes on fetal spinal structure, especially in brachial enlargement. Sixteen adult female rats were divided into two groups. Diabetes was induced in one group by alloxan agent. Both groups became pregnant by natural matting. On days 7, 14, 21 and 28 after birth, the brachial enlargement of the spinal cord was collected from offspring of all rats and the weight of neonates was measured. Various histological parameters were determined using histological techniques. The results revealed a significant decrease in transverse spinal diameter and number of neurons of gray matter and an increase in vertical spinal diameter in spinal cord of offspring of diabetic mothers (ODM) as compared with the control group. The body weight of ODM was significantly more than that of the control group (P<0.05). Maternal hyperglycemia exhibited deleterious effects on spinal cord, especially brachial enlargement during fetal life which remained persistent during postneonatal period.
    Iranian Journal of Veterinary Research 11. · 0.22 Impact Factor