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Publications (3)2.93 Total impact

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    ABSTRACT: To investigate the fetal cerebral lobes development between 20 and 28 weeks gestational age, 36 fetus specimen without CNS abnormality, with 4 fetuses in each gestation week, were scanned with 3.0T MR. Lobular parameters were measured, including the parenchyma thickness of the frontoparietal and the temporal lobes, the margin length of frontoparietal, the insula and the temporal lobes, the Sylvian fissure and the perimeter of hippocampus, on the plane perpendicular to the longitudinal axis of hippocampus body across the base of cerebral peduncle. The relative value of parenchyma thickness and the lobes' length ratios to the same side hemisphere were calculated and their correlation with gestational weeks was analyzed. All measured parameters were positively correlated with gestational age. No significant tendency was found for relative value of the parenchyma thickness (P>0.05). The temporal lobe length ratio increased while the frontoparietal ratio decreased before 24 weeks GA and then the two reversed. The Sylvian fissure length ratio increased (P<0.001) and the hippocampus decreased (P<0.001) throughout this period. In conclusion, the early fetal cerebrum lobes developed asynchronously during this period, the 24 weeks GA could be a turning point for cerebrum development pattern changing from primitive to mature.
    International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience 09/2013; · 2.03 Impact Factor
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    ABSTRACT: PURPOSE To determine the altered pattern of FA and ADC change in in serially studied neonates with mild, moderate or severe hypoxic ischemic injury (HIE) METHOD AND MATERIALS The study included 20 normal babies as age/sex-matched control and 30 babies (32 term neonates) who were diagnosed with mild (n = 8), moderate (n = 7) and severe( n=5) HIE within 7 days after birth and again at the age of three month with conventional and serial diffusion tensor cerebral MR imaging. Neurodevelopmental outcome was assessed at the time of the 2nd study. RESULTS On comparing FA and ADC changes over time using two-way analysis of variance between neonates with HIE and controls, we observed significant differences in age-related FA increase (p < 0.05) in anterior limb of internal capsule and periventricular white matter of parietal, occipital, and temporal lobes. Significant differences in age-related ADC decrease (p < 0.05) was observed in the caudate nuclei, and temporal white matter among these groups. Significant positive correlation was observed between neurodevelopmental outcome and FA. There was significant difference between conventional MR imaging and DTI in detecting sequelae at the end of three month. CONCLUSION the results suggest that abnormal FA and ADC values help in early and more accurate assessment of microstructural damage in HIE that may have predictive value for long-term neurofunctional outcome in these neonates.DTI is superior to other imaging modalities in detecting sequelae. CLINICAL RELEVANCE/APPLICATION Diffusion tensor imaging may have predictive value for long-term neurofunctional outcome in these neonates, which was a useful tool for predicting the individual outcomes of neonates with HIE.
    Radiological Society of North America 2007 Scientific Assembly and Annual Meeting; 11/2007
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    ABSTRACT: To study the clinical value of a new MRI compatible percutaneous bone biopsy system. Twenty-six patients with bone lesions MRI-guided biopsies underwent using a 0.23-T open MR system combined with an iPath-200 optical leading system. Of the 26 biopsies, 23 samples were sufficient for histological examination and the histopathologic diagnoses were confirmed. In the high-risk areas like spine, the biopsies were successfully done in 11 patients. No procedural complications occurred. Percutaneous biopsy of bone lesions performed under MRI-guidance in an iPath system was proved to be accurate and safe.
    Chinese medical journal 07/2003; 116(6):937-40. · 0.90 Impact Factor