Woo Jeong Kim

Chiba University, Tiba, Chiba, Japan

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Publications (2)2.87 Total impact

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    ABSTRACT: Thymus and activation-regulated chemokine (TARC/CCL17) is a highly specific ligand for CCR 4. TARC may contribute to the recruitment, activation, and development of Th2 polarized cells that express CCR4. These characteristics have led investigators to hypothesize that TARC is involved in the development of Th2 responses. Suplatast tosilate ((±)-[2-[4-(3-ethoxy-2-hydroxy-propoxy) phenylcarbamoyl] ethyl] dimethylsulfonium p-toluenesulfonate) is an anti-allergic agent that selectively suppresses the synthesis of Th2 cytokines. We examined the effect of suplatast tosilate on TARC production and CCR-4 expression in vitro. Furthermore, we attempted to clarify whether TARC production was suppressed after clinical administration of suplatast tosilate.
    Allergology International 12/2005; 54(3):373-380. DOI:10.2332/allergolint.54.373
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    ABSTRACT: In allergic inflammation involving allergic rhinitis, the predominance of Th(2) lymphocytes is one of the primary causal agents in promotion of the allergic condition. Thymus and activation-regulated chemokine (TARC/CCL17) is a recently identified chemokine that induces the development of Th(2) lymphocytes. One of the sources of TARC has been reported to be peripheral blood mononuclear cells (PBMCs). We investigated TARC production from PBMCs by the stimulation of specific antigens and Th(2) type cytokines. PBMCs were isolated from both allergic rhinitis patients and healthy volunteers. PBMCs were incubated with cytokine. TARC mRNA expression was examined by real time PCR methods and the amount of TARC production was examined by ELISA. IL-13 was found to be the most potent inducer for TARC mRNA expression and protein production in PBMCs. Furthermore, tumour necrosis factor alpha and IL-13 synergistically induce TARC. The amount of TARC from allergic rhinitis patients was significantly larger than that from healthy volunteers. Moreover, TARC was induced by a specific antigen, and was 35% inhibited by an anti-IL-13 neutralizing antibody. These results indicate that IL-13 is important in TARC mediated Th(2) lymphocytes infiltration in the nasal mucosa.
    Cytokine 11/2002; 20(2):49-55. DOI:10.1006/cyto.2002.1979 · 2.87 Impact Factor

Publication Stats

19 Citations
2.87 Total Impact Points

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Institutions

  • 2002–2005
    • Chiba University
      • • Department of Otorhinolaryngology, Head and Neck Surgery
      • • Department of Otorhinolaryngology
      Tiba, Chiba, Japan