Vučetić Dragana

Publications (2)0 Total impact

• Article: COLOR DOPPLER AND COLOR DOPPLER ENERGY IMAGING AND MEASUREMENTS OF INTRAOVARIAN VASCULARISATION DURING LUTEAL PHASE OF MENSTRUAL CYCLE

  Kutlešić Ranko, Popović Jasmina, Vukomanović Predrag, Stefanović Milan, Vidović Bratislav, Janjić Zoran, Vučetić Dragana
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  ABSTRACT: The aim of this investigation was to determine if there were differences: (1) in color Doppler (CD) ultrasound imaging and measurements of periluteal vascularisation in ovary bearing corpus luteum and stromal blood flow of contralateral ovary in ovulatory cycle, and (2) between intraovarian midluteal vascularisation in the group of ovulatory patients and ovarian stromal blood flow of the 21st cycle day in the patients with anovulatory cycles. This prospective clinical investigation involved 205 patients divided into two groups: with ovulatory and anovulatory cycles. CD ultrasound examination of intraovarian vascularisation were performed during menstrual cycle, and CD indices were analyzed: pulsatile index PI, resistance index RI, and systolic/diastolic - S/D ratio. PI was statistically significantly lower in the group of ovulatory patients: 0.8 ± 0.14 vs 1.265 ± 0.41. The same was true for RI ( 0.51 ± 0.04 vs 0.65 ± 0.07) and for S/D ratio (2.08 ± 0.23 vs 2.91 ± 0.58. Resistance to blood flow in periluteal vessels during the midluteal phase was lower than in stromal vessels of nondominant ovary in ovulatory patients (PI 0.8 ± 0.14 vs 2.08 ± 0.31; RI 0.51 ± 0.04 vs 0.74 ± 0.1 and S/D ratio 2.08 ± 0.23 vs 4.25 ± 1.76). Our investigation showed that the resistance to intraovarian blood flow was lower in ovulatory compared to anovulatory cycles. The same was true for intraovarian – periluteal vascularisation in the ovary with corpus luteum compared to stromal vascularisation of nondominant ovary.
  Acta Facultatis Medicae Naissensis. 01/2009;
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  Available from: ni.ac.rs

  Article: RECURRENT MICROSCOPIC GRANULOSA CELL TUMOR OF THE OVARY 21 YEARS AFTER INITIAL OPERATION

  Milosavljević Mileva, Vukomanović Predrag, Kutlešić Ranko, Stefanović Milan, Vučetić Dragana
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  ABSTRACT: Granulosa cell tumors of the ovary are rare hormonally active neoplasms characterized by endocrine manifestations, an indolent course, and late relapse. These tumors have preponderance for local spread and extremely late recurrence and high survival rates. Late recurrence can be extensive with initial, clinically undetectable, microscopic granulosa cell tumor of the ovary. Only a small percentage of such tumors metastasize.We report a case of a 71-year-old woman with extensive recurrent granulosa cell tumor of the ovary 21 years after undergoing abdominal hysterectomy and bilateral salpingo-oophorectomy for atypical endometrial hyperplasia. 20 years after the initial treatment, she was well without evidence of the disease. 21 years after the initial treatment, abdominal pain was abrupt followed by unstable vital signs. Under the impression of internal bleeding, immediate laparotomy was performed. Macroscopic examination revealed predominantly cystic mass filled with clotted blood and separated by solid tissue. Biopsy showed granulosa cell tumor of the ovary. A thorough staging surgery included lymph node sampling, partial omentectomy and excision of any suspicion lesions within the abdominal cavity. The final pathologic expertise confirmed malignant granulosa cell tumor of the ovary. At the pathohystological re-expertise of the first operation material, the diagnosis of the initial, microscopic granulosa cell tumor of the ovary was confirmed. By pathological analysis of the second operation material, the diagnosis of malignant granulosa cell tumor of the ovary was confirmed.Autors describe a case of microscopic granulosa cell tumor of the ovary, which recurred 21 years after the original surgery. Late recurrence can be extensive with initial, clinically undetectable, microscopic granulosa cell tumor of the ovary. Patients must be monitored closely after a diagnosis of ovarian granulosa cell tumor, even if the tumor is occult. This case report emphasises the need for long-term follow-up in patients with granulosa cell tumors of the ovary and considers the possibility of recurrence when presented with acute abdomen after conservative treatment.
  Acta Medica Medianae. 01/2007;