Victoria Grochocinski

Publications (2)14.4 Total impact

• Article: Age at onset in bipolar I affective disorder in the USA and Europe.

  Frank Bellivier, Bruno Etain, Alain Malafosse, Chantal Henry, Jean-Pierre Kahn, Orly Elgrabli-Wajsbrot, Stéphane Jamain, Jean-Michel Azorin, Ellen Frank, Jan Scott, Victoria Grochocinski, David J Kupfer, Jean-Louis Golmard, Marion Leboyer
  [show abstract] [hide abstract]
  ABSTRACT: Objective. To test for differences in reported age at onset (AAO) of bipolar I affective disorder in clinical samples drawn from Europe and the USA. Methods. Admixture analysis was used to identify the model best fitting the observed AAO distributions of two large samples of bipolar I patients from Europe and USA (n = 3616 and n = 2275, respectively). Theoretical AAO functions were compared between the two samples. Results. The model best fitting the observed distribution of AAO in both samples was a mixture of three Gaussian distributions. The theoretical AAO functions of bipolar I disorder differed significantly between the European and USA populations, with further analyses indicating that (i) the proportion of patients belonging to the early-onset subgroup was higher in the USA sample (63 vs. 25%) and (ii) mean age at onset (±SD) in the early-onset subgroup was lower for the USA sample (14.5 ± 4.9 vs. 19 ± 2.7 years). Conclusions. The models best describing the reported AAO distributions of European and USA bipolar I patients were remarkably stable. The intermediate- and late-onset subgroups had similar characteristics in the two samples. However, the theoretical AAO function differed significantly between the USA and European samples due to the higher proportion of patients in the early-onset subgroup and the lower mean age-at-onset in the USA sample.
  The World Journal of Biological Psychiatry 12/2011; · 2.38 Impact Factor
• Article: Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder.

  Ellen Frank, David J Kupfer, Michael E Thase, Alan G Mallinger, Holly A Swartz, Andrea M Fagiolini, Victoria Grochocinski, Patricia Houck, John Scott, Wesley Thompson, Timothy Monk
  [show abstract] [hide abstract]
  ABSTRACT: Numerous studies have pointed to the failure of prophylaxis with pharmacotherapy alone in the treatment of bipolar I disorder. Recent investigations have demonstrated benefits from the addition of psychoeducation or psychotherapy to pharmacotherapy in this population. To compare 2 psychosocial interventions: interpersonal and social rhythm therapy (IPSRT) and an intensive clinical management (ICM) approach in the treatment of bipolar I disorder. Randomized controlled trial involving 4 treatment strategies: acute and maintenance IPSRT (IPSRT/IPSRT), acute and maintenance ICM (ICM/ICM), acute IPSRT followed by maintenance ICM (IPSRT/ICM), or acute ICM followed by maintenance IPSRT (ICM/IPSRT). The preventive maintenance phase lasted 2 years. Research clinic in a university medical center. One hundred seventy-five acutely ill individuals with bipolar I disorder recruited from inpatient and outpatient settings, clinical referral, public presentations about bipolar disorder, and other public information activities. Interpersonal and social rhythm therapy, an adaptation of Klerman and Weissman's interpersonal psychotherapy to which a social rhythm regulation component has been added, and ICM. Time to stabilization in the acute phase and time to recurrence in the maintenance phase. We observed no difference between the treatment strategies in time to stabilization. After controlling for covariates of survival time, we found that participants assigned to IPSRT in the acute treatment phase survived longer without a new affective episode (P = .01), irrespective of maintenance treatment assignment. Participants in the IPSRT group had higher regularity of social rhythms at the end of acute treatment (P<.001). Ability to increase regularity of social rhythms during acute treatment was associated with reduced likelihood of recurrence during the maintenance phase (P = .05). Interpersonal and social rhythm therapy appears to add to the clinical armamentarium for the management of bipolar I disorder, particularly with respect to prophylaxis of new episodes.
  Archives of General Psychiatry 10/2005; 62(9):996-1004. · 12.02 Impact Factor