Tsuyoshi Chihara

Publications (2)3.42 Total impact

• Article: Kaposiform hemangioendothelioma arising in the deltoid muscle without the Kasabach-Merritt phenomenon.

  Noriyuki Tamai, Yoshiko Hashii, Keigo Osuga, Tsuyoshi Chihara, Eiichi Morii, Katsuyuki Aozasa, Hideki Yoshikawa
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  ABSTRACT: Kaposiform hemangioendothelioma (KHE) is a rare tumor that occurs nearly exclusively during infancy and childhood. It has features common to both capillary hemangioma and Kaposi sarcoma and for that reason many terms have been used for these tumors including "Kaposi-like infantile hemangioendothelioma" and "hemangioma with Kaposi sarcoma-like features." KHE typically presents as an ill-defined, red to purple, indurated plaque and is often complicated by the Kasabach-Merritt phenomenon (KMP), a condition of severe thrombocytopenia and consumptive coagulopathy. Knowledge of the radiological findings of this uncommon tumor might be helpful for diagnosis. We present the MRI features of a case of KHE with neither typical skin lesions nor the Kasabach-Merritt phenomenon.
  Skeletal Radiology 03/2010; 39(10):1043-6. · 1.54 Impact Factor
• Article: Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism.

  Kazuhiko Bessho, Yuri Etani, Hiroaki Ichimori, Yoko Miyoshi, Noriyuki Namba, Akihiro Yoneda, Takaharu Ooue, Tsuyoshi Chihara, Eiichi Morii, Tomoyuki Aoki, Masami Murakami, Sotaro Mushiake, Keiichi Ozono
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  ABSTRACT: Infantile hepatic hemangioma with consumptive hypothyroidism is a rare condition. A 4-month-old girl presented with diffuse hepatic hemangiomas during treatment of congenital hypothyroidism. Serum reverse triiodothyronine was elevated, and her hypothyroidism improved concomitant with involution of the hemangioma following prednisolone and interferon-alpha administration. At 20 months of age, 7 months after discontinuing prednisolone and interferon-alpha, a focal hemangioma regrew from one of the previous lesions and was surgically resected. The expression and activity of type 3 iodothyronine deiodinase (D3) were elevated in the resected tumor tissue compared with placenta. Here, we describe a patient with consumptive hypothyroidism and diffuse infantile hepatic hemangiomas, one of which regrew after involution following pharmacotherapy. The etiology of elevated D3 activity is also discussed. It is important to identify infantile hepatic hemangioma in patients with hypothyroidism refractory to hormone replacement therapy, who have low free triiodothyronine despite high thyrotropin and normal free thyroxine levels, and long-term follow-up will be needed for these patients.
  European Journal of Pediatrics 07/2009; 169(2):215-21. · 1.88 Impact Factor