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ABSTRACT: A miniflow system for oxidative cyclization of alkenols with Oxone was developed. Thus, the oxidative cyclization of ( Z )- and ( E )-alkenols in i -PrOH with an aqueous solution of Oxone proceeded smoothly and safely in a PTFE tube without any exogenous catalytic species, and was subsequently quenched in a flow-reaction manner to afford the corresponding furanyl and pyranyl carbinols quantitatively within 5 or 10 min of residence time.
Beilstein Journal of Organic Chemistry. 01/2009;