Sri Fatmawati

Institut Teknologi Sepuluh Nopember, Surabaya, West Java, Indonesia

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Publications (8)17.27 Total impact

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    ABSTRACT: A series of lanostane-type triterpenoids, identified as ganoderma alcohols and ganoderma acids, were isolated from the fruiting body of Ganoderma lingzhi. Some of these compounds were confirmed as active inhibitors of the in vitro human recombinant aldose reductase. This paper aims to explain the structural requirement for α-glucosidase inhibition. Our structure-activity studies of ganoderma alcohols showed that the OH substituent at C-3 and the double-bond moiety at C-24 and C-25 are necessary to increase α-glucosidase inhibitory activity. The structure-activity relationships of ganoderma acids revealed that the OH substituent at C-11 is an important feature and that the carboxylic group in the side chain is essential for the recognition of α-glucosidase inhibitory activity. Moreover, the double-bond moiety at C-20 and C-22 in the side chain and the OH substituent at C-3 of ganoderma acids improve α-glucosidase inhibitory activity. These results provide an approach with which to consider the structural requirements of lanostane-type triterpenoids from G. lingzhi. An understanding of these requirements is considered necessary in order to improve a new type of α-glucosidase inhibitor.
    Bioorganic & medicinal chemistry letters 09/2013; · 2.65 Impact Factor
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    ABSTRACT: A series of lanostane-type triterpenoids, known as ganoderma acids were isolated from the fruiting body of Ganoderma lucidum. Some of these compounds were identified as active inhibitors of the in vitro human recombinant aldose reductase. To clarify the structural requirement for inhibition, some structure-activity relationships were determined. Our structure-activity studies of ganoderma acids revealed that the OH substituent at C-11 is an important feature and the carboxylic group in the side chain is essential for the recognition of aldose reductase inhibitory activity. Moreover, double bond moiety at C-20 and C-22 in the side chain contributes to improving aldose reductase inhibitory activity. In the case of ganoderic acid C2, all of OH substituent at C-3, C-7 and C-15 is important for potent aldose reductase inhibition. These results provide an approach to understanding the structural requirements of ganoderma acids from G. lucidum for aldose reductase inhibitor. This understanding is necessary to design a new-type of aldose reductase inhibitor.
    Bioorganic & medicinal chemistry letters 10/2011; 21(24):7295-7. · 2.65 Impact Factor
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    ABSTRACT: α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC(50) of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3,26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, with an IC(50) of 48.5 μg/ml (119.8 μM).
    Phytomedicine: international journal of phytotherapy and phytopharmacology 05/2011; 18(12):1053-5. · 2.97 Impact Factor
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    ABSTRACT: Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC(50) of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.
    Fitoterapia 12/2010; 81(8):1033-6. · 2.23 Impact Factor
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    ABSTRACT: CHCl(3) extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.
    Planta Medica 04/2010; 76(15):1691-3. · 2.35 Impact Factor
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    ABSTRACT: The human aldose reductase inhibitory effects of the methanol extracts of 17 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum on the galactitol level in the eye lens was studied in a galactosemic rat model in vivo. This mushroom significantly decreased the galactitol accumulation.
    Phytotherapy Research 01/2009; 23(1):28-32. · 2.07 Impact Factor
  • S Fatmawati, J Liu, K Shimizu, R Kondo
    Planta Medica 07/2008; 74(9):1002. · 2.35 Impact Factor
  • Sri Lestari Fatmawati
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    ABSTRACT: Soya bean is also known as green manure because it can increase soil fertility level. Nowadays, agricultural fields in Indonesia has drastically lowered in number to become housing and accomodate industrial purposes. Soya bean planting using agroforestry system is considered to overcome such problems in Indonesia as well as an effort to optimize under-tree spaces (forest vegetations). Soya bean rooting system is capable of forming nodulation in which Rhizobium japonicum bacteria colonize. Rhizobium bacteria establish such beneficial symbiosis with soya bean roots to fixate free nitrogen (N2) from air (Rahmat, 1995). Rhizobium japonicum is employed as an effort to increase the number of soil-living rhizobium bacteria which in turn provide the plant with Nitrogen and thus increase the soya bean production (Freire, et. al. 1977). Bradyrhizobium japonicum inoculum on soya bean is necessarily needed if soil nitrogen is the limiting factor of plant growth (Idiyah, 1997). Rhizobium infection and colonization into plant roots and initial root nodules are fully influenced by Ca. Ca is needed in rhizobium infection on interface level with medium of soil (Yutono, 1985). This research is conducted to isolate, select, and describe Bradyrhizobium japonicum in soya bean grown under sengon tree. The research was conducted in trial field of Muhammadiyah University of Malang in Tegalgondo and Biotechnology laboratory of Muhammadiyah University of Malang starting from April up to October 2007. Stages of operation include field preparation, soya bean seed planting, nodules picking up, nodules sterilization, Bradyrhizobium japonicum isolation, keeping of isolated strains, Gram Test, and bacteria portrayal. The research resulted in that by isolating, selecting, and describing 7 bacteria strains were found on the basis of its growth speed and share same characters including varyingly colony colors, from yellow to brownish white with colony tip is branched round to fully round and share the same thickness (Thick).

Publication Stats

23 Citations
17.27 Total Impact Points

Institutions

  • 2011–2013
    • Institut Teknologi Sepuluh Nopember
      • Department of Chemistry
      Surabaya, West Java, Indonesia
  • 2009–2013
    • Kyushu University
      • • Department of Agro-environmental Sciences
      • • Faculty of Agriculture
      Hukuoka, Fukuoka, Japan