Junmo Hwang,
Hyung-Soo Kim,
Ji-Woong Seok,
Jun-Dae Kim, Soonil Koun,
So-Young Park,
Jinseok Lee,
Hyang Sook Kim,
Hyung-Seok Kim,
Kil Soo Kim,
Kyu-Tae Chang,
Zae Young Ryoo,
San Ming Wang,
Tae-Lin Huh,
Sanggyu Lee
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ABSTRACT: Mind bomb (Mib) facilitates Notch signaling pathway by promoting the endocytosis of Notch ligand. The zebrafish mib
ta52b
mutant has a defect in its ubiquitin ligase activity which is necessary to inhibit the neurogenesis, resulting in a neuronal
hyperplasia. Several genes regulated in the mib
ta52b
mutant have been well established, however, there were relatively few reports about the transcriptome profile. To identify
the genes differentially expressed in the mib
ta52b
mutant, genome-wide analysis was performed using serial analysis of gene expression. Three hundred and thirty-five transcripts
were identified whose expressions were significantly altered in the mib
ta52b
mutant as compared with the wild-type. Interestingly, it was suggested that the mib
ta52b
mutation may affect not only neurogenesis but also mesoderm development. These results provide new insights into Notch signaling
pathway.
Molecular and General Genetics 12/2008; 281(1):77-85. · 2.63 Impact Factor
