Publications (2)19.61 Total impact
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Article: Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory.
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ABSTRACT: Cyclic AMP response element binding protein (CREB) plays a critical role in fear memory formation. Here we determined the role of CREB selectively within the amygdala in reconsolidation and extinction of auditory fear. Viral overexpression of the inducible cAMP early repressor (ICER) or the dominant-negative mCREB, specifically within the lateral amygdala disrupted reconsolidation of auditory fear memories. In contrast, manipulations of CREB in the amygdala did not modify extinction of fear. These findings suggest that the role of CREB in modulation of memory after retrieval is dynamic and that CREB activity in the basolateral amygdala is involved in fear memory reconsolidation.Learning & memory (Cold Spring Harbor, N.Y.) 01/2012; 19(5):178-81. · 4.08 Impact Factor -
Article: Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A.
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ABSTRACT: Reconsolidation-the stabilization of a memory after retrieval-is hypothesized to be a critical and distinct component of memory processing, the disruption of which results in memory impairment. In the rat, we found that activation of amygdalar protein kinase A (PKA) was sufficient to enhance memory only when it was retrieved; in contrast, PKA inhibition impaired reconsolidation. This study demonstrates both a selective enhancement and an impairment of memory reconsolidation dependent on amygdalar PKA.Nature Neuroscience 03/2006; 9(2):167-9. · 15.53 Impact Factor
