Senol Akay

Georgia State University, Atlanta, GA, United States

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Publications (2)5.57 Total impact

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    ABSTRACT: Cell surface glycoproteins have been known to play very important roles in various physiologic and pathologic processes. Small molecule compounds capable of carbohydrate recognition can be very useful for the development of sensing, diagnostic, and therapeutic agents. Along this line, we are interested in developing water-soluble fluorescent boronic acid compounds for carbohydrate recognition. As such, a series of benzo[b]thiophene boronic acid derivatives have been synthesized and their fluorescent properties analyzed at physiologic pH. Benzo[b]thiophene derivatives were found to be a new type of fluorescent reporter compounds capable of dual fluorescent emission under physiologic pH conditions. Compounds 1, 3, 4, 5, and 6 showed unusual emission wavelength shifts upon binding of sugars. These boronic acids will be useful tools for building glycoprotein biosensors for biologic applications.
    Chemical Biology &amp Drug Design 11/2007; 70(4):279-89. · 2.47 Impact Factor
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    ABSTRACT: Three new fluorescent probes based on the 4-amino-1,8-naphthalimide structure were synthesized, and their sugar binding properties were studied by using D-fructose, D-glucose and D-sorbitol in 0.1 M phosphate buffer at pH 7.4. All three compounds showed fluorescence intensity changes upon addition of sugars. In this series, compound 1c gave the longest emission wavelength (570 nm) and fluorescence intensity increases of up to 2.5-fold after addition of D-fructose.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
    Annalen der Chemie und Pharmacie 03/2007; 2007(13):2091 - 2099. · 3.10 Impact Factor