S Porubcin

Publications (2)1.08 Total impact

• Article: Impact of TTV and SENV infection in chronic hepatitis B or C on liver histology and therapy outcome.

  P Kristian, I Schreter, L Siegfried, P Jarcuska, Z Paralicova, S Porubcin
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  ABSTRACT: To determine the influence of TTV and SENV on histological findings and viral response in patients with chronic viral hepatitis B and C. The clinical impact of TTV or SENV coinfections in these patients remains unclear. Serum and liver biopsy specimens from chronic hepatitis B and C patients, 107 with liver biopsy and 105 who had finished complete antiviral therapy, were investigated for the presence of TTV and SENV. The Ishak score determined from 107 liver biopsy samples compared according to TTV or SENV coinfection was similar. Among 39 chronic hepatitis C patients with and 43 without virological response, we have found 9 and 3 SENV positive (p < 0.05) and 18 and 28 TTV positive patients, respectively (not significant). However 11 of 32 biopsy samples obtained in the responder's group and 19 of 31 in non-responders were TTV positive (p < 0.05). No similar differences were observed among 23 chronic hepatitis B patients. TTV clearance after interferon therapy exceeded 80%, clearance of SENV 90%. TTV or SENV infections did not negatively influence the severity of histological features or the antiviral response in patients with chronic hepatitis B and C. Both viruses were highly sensitive to interferon therapy (Tab. 5, Ref. 29).
  Bratislavske lekarske listy 01/2010; 111(12):629-34. · 0.40 Impact Factor
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  Article: Detection of SEN virus in the general population and different risk groups in Slovakia.

  I Schréter, P Kristian, P Jarcuska, S Porubcin, L Siegfried, E Birosová, A Rajnic, A Gocalová
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  ABSTRACT: Sera of 426 adult persons were examined to assess the prevalence of SEN virus (SENV) infection in Slovakia and to determine the importance of different risk factors for parenteral transmission. SENV prevalence was determined by the PCR method using primers of SENV-D and SENV-H strains. Positive results were found in 10 of 37 patients with acute hepatitis of unknown etiology, 7 of 38 with acute hepatitis B, 17 of 44 with chronic hepatitis B, 29 of 102 with chronic hepatitis C, 36 of 72 hemodialysis patients, 2 of 33 health care workers and 24 of 100 persons from the control group. The highest prevalence of SENV was among hemodialysis patients, significantly higher than in the groups of health care workers, acute hepatitis B and controls. The lowest prevalence was in health care workers group, significantly lower also in comparison with groups of chronic hepatitis B and C. Among the possible risk factors of virus transmission the average duration of hemodialysis (1.15 vs. 0.50 years), number of surgeries (1.60 vs. 1.10) and transfusions (1.34 vs. 0.94) showed notable differences in terms of SENV infection. Bilirubin and aminotransferase levels did not differ between SENV-positive and -negative groups. No pathogenetic role of SEN virus in liver injury was confirmed.
  Folia Microbiologica 02/2006; 51(3):223-8. · 0.68 Impact Factor