Sim Nodes

Freie Universität Berlin, Berlín, Berlin, Germany

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Publications (1)2.28 Total impact

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    ABSTRACT: We have previously shown that hepoxilin A3 increases the intracellular concentration of Ca+2 in human neutrophils. Herein we address the initial events of hepoxilin action on the neutrophil which precede the rise in intracellular calcium. We show that hepoxilin A3 at 10-1000 nM concentrations releases from [1-14C]-arachidonic acid labeled neutrophils diacylglycerol and unesterified arachidonic acid in a time and concentration dependent fashion. The release of arachidonic acid and diacyglycerol are receptor-mediated events which are blocked by pertussis toxin. This data shows that hepoxilin A3 stimulates phospholipases C and A2 in the cell which may be involved in the rise in cytosolic calcium. Thus, hepoxilins may represent a hitherto unrecognised class of cellular mediators.
    Biochemical and Biophysical Research Communications 10/1990; 171(3):944-8. DOI:10.1016/0006-291X(90)90775-I · 2.28 Impact Factor

Publication Stats

33 Citations
2.28 Total Impact Points

Institutions

  • 1990
    • Freie Universität Berlin
      Berlín, Berlin, Germany