S Laïque

Université Libre de Bruxelles, Bruxelles, Brussels Capital Region, Belgium

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Publications (1)2.87 Total impact

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    ABSTRACT: Labeled amino acids (AA) are tumor tracers for use in nuclear medecine. O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) is transported by the L-system, known to function as an exchanger. In vitro utilization of FET, after a preload or prior to an afterload of non radioactive L-amino acids, was evaluated in order to measure the potential effects of AA content on the distinction between tumor and inflammatory lesions. Cellular uptake of FET was studied on rat osteosarcoma cells (ROS 17/2.8) and human leukocytes, initially loaded with nonradioactive L-tyrosine or L-methionine. FET efflux was evaluated from cells loaded with nonradioactive L-phenylalanine after tracer uptake. ROS 17/2.8 showed a higher sensitivity to preload and afterload effects on cellular FET content as compared with the leukocytes. We conclude that preload with L-tyrosine, prior to the administration of FET, may be a potential procedure to improve PET differentiation between tumor and inflammatory lesions.
    Contrast Media & Molecular Imaging 10/2006; 1(5):212-20. · 2.87 Impact Factor

Publication Stats

6 Citations
2.87 Total Impact Points

Institutions

  • 2006
    • Université Libre de Bruxelles
      Bruxelles, Brussels Capital Region, Belgium