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ABSTRACT: Changes of left ventricular systolic function in acute myocardial infarction are well known. However, diastolic function may also have a role for patients' symptoms and prognosis. The purpose of this study was to evaluate changes of diastolic function non-invazively and to delineate the relation between systolic and diastolic function. 52 patients with acute myocardial infarction were examined by Doppler echocardiography within the first 48 hours and one week later. Systolic function was defined by left ventricular outflow velocity measurements, diastolic function was characterized by mitral inflow parameters and patterns. Four types of mitral inflow were determined: normal pattern, patterns suggesting prolonged relaxation, pattern suggesting elevated filling pressure and "normalized" pattern. In the last situation the influence of prolonged relaxation and elevated filling pressure equalized each others effect producing a "normalized" inflow pattern. Diastolic function improved in 18 cases and impaired in 9 pts, systolic function improved only in 11 cases and decreased in 28 pts by the time of the second examination. Worsening of diastolic function was always accompanied by worsening of systolic function. Despite improving diastolic function, worsening in systolic function could be observed in 8 cases. Monitoring of patients with acute myocardial infarction by Doppler echocardiography offers a possibility to select high risk patients with worsening left ventricular function for further closer follow-up.Orvosi Hetilap 03/1996; 137(8):395-400.