Roseanna Presutti

Publications (2)6.68 Total impact

• Article: Prophylaxis of radiotherapy-induced nausea and vomiting in the palliative treatment of bone metastases.

  Kristopher Dennis, Janet Nguyen, Roseanna Presutti, Carlo DeAngelis, May Tsao, Cyril Danjoux, Elizabeth Barnes, Arjun Sahgal, Lori Holden, Florencia Jon, Shun Wong, Edward Chow
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  ABSTRACT: To document the incidence and timing of radiotherapy-induced nausea and vomiting (RINV) in the treatment of bone metastases among patients receiving prophylaxis with a 5-HT(3) receptor antagonist. Patients receiving single (SF) or multiple fraction (MF) palliative radiotherapy (RT) of moderate or low emetogenic risk for bone metastases were prescribed prophylactic Ondansetron. The frequency and duration of prophylaxis and the use of rescue antiemetics were left to the discretion of the treating physicians. Patients documented episodes of nausea (N) and vomiting (V) in daily diaries before and during RT, and until 10 days following RT completion. Rates of complete prophylaxis (CP) for N&V, respectively (CP = no event and no rescue medication), were calculated for the acute phase (the period from the start of RT to the first day following RT completion inclusive) and the delayed phase (the second to tenth days following RT completion inclusive). Fifty-nine patients were enrolled, and 32 were evaluable. CP rates were as follows: moderate-risk SF group (n = 16), acute phase (CP for N = 56%, CP for V = 69%) and delayed phase (CP for N = 31%, CP for V = 44%); moderate-risk MF group (n = 7), acute phase (CP for N = 71%, CP for V = 57%) and delayed phase (CP for N = 43%, CP for V = 57%); low-risk SF group (n = 8), acute phase (CP for N = 50%, CP for V = 100%) and delayed phase (CP for N = 43%, CP for V = 57%); and low-risk MF group (n = 1), acute phase (CP for N = 100%, CP for V = 100%) and delayed phase (CP for N = 100%, CP for V = 100%). Despite prophylaxis, RINV was common among patients receiving palliative radiotherapy for bone metastases, especially during the delayed phase.
  Supportive Care in Cancer 09/2011; 20(8):1673-8. · 2.09 Impact Factor
• Article: Elderly patients with painful bone metastases should be offered palliative radiotherapy.

  Sarah Campos, Roseanna Presutti, Liying Zhang, Nadia Salvo, Amanda Hird, May Tsao, Elizabeth A Barnes, Cyril Danjoux, Arjun Sahgal, Gunita Mitera, Emily Sinclair, Carlo DeAngelis, Janet Nguyen, Julie Napolskikh, Edward Chow
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  ABSTRACT: To investigate the efficacy of palliative radiotherapy (RT) in relieving metastatic bone pain in elderly patients. The response to RT for palliation of metastatic bone pain was evaluated from a prospective database of 558 patients between 1999 and 2008. The pain scores and analgesic intake were used to calculate the response according to the International Bone Metastases Consensus Working Party palliative RT endpoints. Subgroup analyses for age and other demographic information were performed. No significant difference was found in the response rate in patients aged >or=65, >or=70, and >or=75 years compared with younger patients at 1, 2, or 3 months after RT. The response was found to be significantly related to the performance status. Age alone did not affect the response to palliative RT for bone metastases. Elderly patients should be referred for palliative RT for their painful bone metastases, regardless of age, because they receive equal benefit from the treatment.
  International journal of radiation oncology, biology, physics 06/2009; 76(5):1500-6. · 4.59 Impact Factor