Roman A. Ivanov

Publications (2)2.9 Total impact

• Article: High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation as a treatment option in multiple sclerosis.

  Yury L Shevchenko, Andrei A Novik, Aleksey N Kuznetsov, Boris V Afanasiev, Igor A Lisukov, Vladimir A Kozlov, Oleg A Rykavicin, Tatyana I Ionova, Vladimir Y Melnichenko, Denis A Fedorenko, Alexander D Kulagin, Sergei V Shamanski, Roman A Ivanov, Gary Gorodokin
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  ABSTRACT: High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell transplantation (auto-HSCT) is a new and promising approach to the treatment of multiple sclerosis (MS) patients because currently there are no effective treatment methods for this disease. In this article, we present results of a prospective clinical study of efficacy of HDIT + auto-HSCT in MS patients. The following treatment strategies were employed in the study: "early," "conventional," and "salvage/late" transplantation. Fifty patients with various types of MS were included in this study. No toxic deaths were reported among 50 MS patients; transplantation procedure was well-tolerated by the patients. The efficacy analysis was performed in 45 patients. Twenty-eight patients achieved an objective improvement of neurological symptoms, defined as at least 0.5-point decrease in the Expanded Disability Status Scale (EDSS) score as compared to the baseline and confirmed during 6 months, and 17 patients had disease stabilization (steady EDSS level as compared to the baseline and confirmed during 6 months). The progression-free survival at 6 years after HDIT + auto-HSCT was 72%. Magnetic resonance imaging data were available in 37 patients before transplantation showing disease activity in 43.3%. No active, new, or enlarging lesions were registered in patients without disease progression. In conclusion, HDIT + auto-HSCT suggests positive results in management of patients with different types of MS. Identification of treatment strategies based on the level of disability, namely "early," "conventional," and "salvage/late" transplantation, appears to be feasible to improve treatment outcomes.
  Experimental Hematology 09/2008; 36(8):922-8. · 2.90 Impact Factor
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  Available from: cellulartherapyandtransplantation.com

  Article: Autologous hematopoietic stem cell transplantation in multiple sclerosis

  Yury L. Shevchenko, Andrei A. Novik, Alexey N. Kuznetsov, Boris V. Afanasiev, Igor A. Lisukov, Oleg A. Rykavicin, Аlexandr A. Myasnikov, Vladimir Y. Melnichenko, Denis A. Fedorenko, Tatyana I. Ionova, Roman A. Ivanov, Gorodokin Gary
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  ABSTRACT: Background: Although there is no effective cure for this disease, high-dose chemotherapy (HDCT), together with autologous hematopoietic stem cell transplantation (auto-HSCT) offers promising results in the treatment of multiple sclerosis (MS) patients.Methods: In this paper we present results of a prospective clinical study of safety and efficacy of HDCT+auto-HSCT in MS patients. One hundred and nine patients with various types of MS were included in this study. The patients underwent early, conventional, or salvage/late transplantation.Results: The transplantation procedure was well tolerated by MS patients, with no transplant-related deaths at all. The efficacy analysis was performed in 79 patients. Forty-two achieved an objective improvement of neurological symptoms (defined as a ≥0.5 point decrease in EDSS score as compared to the baseline and confirmed over 6 months), and 37 patients had disease stabilization (steady EDSS level as compared to the baseline and confirmed over 6 months). Quality of life (QoL) was assessed in 44 patients. Thirty-nine patients exhibited a QoL response 1 year after transplantation.Conclusions: This study provides ample evidence in support of HDCT+auto-HSCT efficacy in MS patients. The results obtained show that transplantation appears to be effective in patients with various types of MS.
  Cellular Therapy and Transplantation. 01/2008;