Rakotonirina A

Publications (10)2.34 Total impact

• Source

  Available from: Elisabeth Ngo Bum

  Article: Decoctions of Bridelia micrantha and Croton macrostachyus may have anticonvulsant and sedative effects.

  Ngo Bum E, Ngah E, Ngo Mune R.M, Ze Minkoulou D.M, Talla E, Moto F.C.O, Ngoupaye G.T, Taiwe G.S, Rakotonirina A, Rakotonirina S.V
  Epilepsy & Behavior 07/2012; 24(3):319-323. · 2.34 Impact Factor
• Article: Anxiolytic activity evaluation of four medicinal plants from Cameroon.

  Ngo Bum E, Soudi S, Ayissi E R, Dong C, Lakoulo N H, Maidawa F, Seke P F E, Nanga L D, Taiwe G S, Dimo T, Njikam N, Rakotonirina A, Rakotonirina S V, Kamanyi A
  African Journal of Traditional, Complementary and Alternative medicines. 01/2011; 8:140-143.
• Chapter: Antiepileptic Medicinal Plants used in Traditional

  Ngo Bum E, Taiwe G, Moto FCO, Ngoupaye GT, Vougat RRN, Sakoue VD, Gwa C, Ayissi ER, Dong C, Rakotonirina A, Rakotonirina SV
  01/2011: pages 175-192; , ISBN: ISBN 978-953-307-700-0
• Article: Anticonvulsant and Sedative Activity of Leaves of Senna spectabilis in Mice

  Rakotonirina S.V, Rakotonirina A, Maidawa F, Nanga, Ngoupaye G.T, Pelanken M.M, Taiwe G.S, Njikam N, Nkantchoua G.N, Bum E.N
  [show abstract] [hide abstract]
  ABSTRACT: Senna spectabilis DC. is a small tree, 3 to 5 m, found in tropical areas in Africa, Asia, Australia, Latino and South America. It is used in traditional medicine in Cameroon to treat many diseases (constipation, insomnia, epilepsy, anxiety, etc.). Therefore, the aim of this study was to look scientifically for the anticonvulsant and sedative properties of S. spectabilis . In vivo animal models of epilepsy (Maximal Electroshock (MES), N-Methyl-D-Aspartate (NMDA), Pentylenetetrazol (PTZ) and Strychnine (STR) induced convulsions or turning behavior) and insomnia (diazepam-induced sleep) were used. Mice were divided in six groups: one negative control group, one positive control group and four groups treated with the plant extract, (except for diazepam-induced sleep test). Four doses of the ethanolic extract were used: 100, 200, 500 and 1000 mg kg<SUP>-1</SUP>. The ethanolic extract of the leaves of Senna spectabilis strongly increased the total sleep time induced by diazepam (p<0.001). It also protected mice against Maximal Electroshock (MES) (p<0.01), pentylenetetrazol (p<0.001), picrotoxin (p<0.01) strychnine (p<0.01) and n-methyl-d-aspartate (p<0.001)-induced seizures and turning behavior and increased the latency to the onset of seizure in Isonicotinic Hydrazide Acid (INH) test (p<0.01). The results lead to the conclusion that the extract of Senna spectabilis possesses anticonvulsant and sedative properties in mice and could explain its used in traditional medicine in Africa, in the treatment of insomnia and epilepsy.
  International Journal of Pharmacology. 01/2010;
• Article: Anticonvulsant and Sedative activity of leaves of Senna spectabilis in mice

  Ngo Bum E., Nkantchoua GN, Njifutie Njikam, Taiwe GS, Ngoupaye GT, Pelanken MM, Nanga L, Maidawa F, Rakotonirina A, Rakotonirina SV
  [show abstract] [hide abstract]
  ABSTRACT: 4. (2010). . 6(2), 123-128
  International Journal of Pharmacology. 01/2010; 6:123-128.
• Source

  Available from: Elisabeth Ngo Bum

  Article: Psorospermum Febrifugum Spach (Hypericaceae) Decoction Antagonized Chemically-induced Convulsions in Mice

  E. Ngo Bum, Naami Y.F.C, Soudi S, Rakotonirina S.V, Rakotonirina A
  [show abstract] [hide abstract]
  ABSTRACT: Psorospermum febrifugum Spach is used in traditional medicine in Cameroon to treat epilepsy. The decoction of Psorospermum febrifugum slightly increased the total sleep time induced by diazepam (50 mg kg^-1 i.p.). It � also �protected mice against pentylene tetrazol-, picrotoxin-and strychnine-induced seizures. Dose 300 mg kg^-1 provided 83.3% of protection against pentylene tetrazol-induced clonic convulsions (the same protection as clonazepam 0.1 mg kg^-1). For the strychnine test, Psorospermum febrifugum protected 66.7% of mice at a dose of 1000 mg kg^-1. 83.3% of mice were protected against picrotoxin-induced seizures at a dose of 3000 mg kg^-1. The antagonism of chemically-induced seizures suggests that Psorospermum febrifugum decoction possesses anticonvulsant properties in mice.
  International Journal of Pharmacology. 01/2005;
• Article: Organic and water extracts of Cyperus articulatus (Cyperaceae) inhibited chemically and electrically induced convulsions in mice

  Ngo Bum E., Rakotonirina S.V., Rakotonirina A., Bopelet M.
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  ABSTRACT: 6. (2004). . 4, 99-106.
  Journal of the Cameroon Academy of Sciences. 01/2004; 4:99-106.
• Article: Effect of the decoction of rhizomes of Cyperus articulatus on bicuculline-, N-methyl-D-aspartate- and strychnine-induced behavioural excitation and convulsions in mice

  Ngo Bum E., Gwa C., Ntchapda F., Nyemb N., Sokeng S., Rakotonirina S.V., Rakotonirina A
  Journal of the Cameroon Academy of Sciences. 01/2002; 2:91-95.
• Article: Sedatives properties of the total extract of the rhizome of Cyperus articulatus L.

  Rakotonirina S. V., Ngo Bum E., Rakotonirina A., Bopelet M.
  Fitoterapia. 01/2001; 72:22-29.
• Article: Anticonvulsivant properties of the methanolic extract of Cyperus articulatus (Cyperaceae).

  Ngo Bum E., Schmutz M., Meyer C., Rakotonirina A., Bopelet M., Portet T., Jeker A., Rakotonirina S. V., Olpe H-R, Herrling P.L.
  Journal of Ethnopharmacology. 01/2001; 76:145-150.