Raju R. Kale

Banaras Hindu University, Vārānasi, Uttar Pradesh, India

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Publications (9)18.81 Total impact

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    ABSTRACT: A facile, simple, and high-yielding protocol for synthesis of novel glycosyl azetidines was developed from glycosyl β-amino alcohols via intramolecular cyclization under Mitsunobu reaction conditions.
    Synthetic Communications 12/2012; 42(24):3598-3613. DOI:10.1080/00397911.2011.587079 · 0.98 Impact Factor
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    ABSTRACT: A facile, simple, and high-yielding synthetic protocol for novel glycosyl tetrazoles has been devised from different carbohydrate-containing amides using benzotriazole methodology under mild reaction condition.
    ChemInform 07/2012; 31(2):130-142. DOI:10.1080/07328303.2011.652790
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    ABSTRACT: A novel, one-pot, and highly facile protocol has been devised for an easy access of a series of novel glycosyl carboxamides from aldehydes using diacetoxyiodobenzene in the presence of ionic liquid at ambient temperature.
    Organic Letters 05/2012; 14(12):2936-9. DOI:10.1021/ol3012315 · 6.32 Impact Factor
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    ABSTRACT: Thioquinazolinones react with two equivalents of silver cyanate to give quinazoline-fused azauracils via a cyclodesulfurization process.
    Synlett 05/2011; 42(2):195-198. DOI:10.1002/chin.201121166 · 2.46 Impact Factor
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    ABSTRACT: AbstractBenzotriazole methodology, nowadays recognized as a versatile, useful, and most successful synthesis protocol, has grown from an obscure level to very high popularity, since benzotriazole can easily be introduced into a molecule by a variety of reactions, activates it toward numerous transformations, is sufficiently stable during the course of reactions, and finally can easily be removed at the end of the reaction sequence. In this review, we briefly describe the way benzotriazole methodology has grown to its present height, the opportunities and its potentiality in the synthesis of diverse pharmacologically important heterocyclic skeletons. Graphical abstract KeywordsHeterocycles-Benzotriazole-Cyclization-Ylide
    Monatshefte fuer Chemie/Chemical Monthly 11/2010; 141(11):1159-1182. DOI:10.1007/s00706-010-0378-1 · 1.35 Impact Factor
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    ABSTRACT: A facile and high-yielding protocol for diverse benzotriazoles through intramolecular N-arylation of different o-chloro-1,2,3-benzotriazenes using CuI/Cs2CO3 has been developed.
    Tetrahedron Letters 10/2010; 51(43):5740–5743. DOI:10.1016/j.tetlet.2010.08.083 · 2.39 Impact Factor
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    ABSTRACT: Since past few decades, Room Temperature Ionic Liquids (RTILs) have extensively been used in organic synthesis as solvents, catalysts and catalyst/solvents in chemical as well as enzymatic reactions, whereas their interest in various different branches of science is expanding exponentially. RTILs show an enhanced performance in a number of syntheses involving carbohydrates when compared to the conventional organic solvents owing to their very interesting and attractive features, viz. simple handling, high yield, less reaction time, benign environmental character, ease of synthesis and excellent recyclability. Carbohydrates are not known only for their vital commercial applications as foods, drugs and chemical feed stocks etc., but sugar based molecules are also identified to play pivotal roles in various pathologically and physiologically important biological processes including cellular recognition, adhesion, migration, invasion, communication, bacterial/viral infection, tumor metastasis etc. The clear understanding of role of sugars in these important biological events has led to the increased demand for significant amounts of carbohydrate based molecules for complete chemical, biological, medicinal, and pharmacological investigations. Therefore, tremendous efforts have been made to develop novel and facile procedures for the synthesis of sugar based molecules of great biological interest and their modification. With an increasing focus on the glycomics, the RTILs solvent may offer promising solutions in carbohydrate chemistry. However, there is lack of recent and concise reports dealing with the RTILs in the field of carbohydrate chemistry particularly, in relevance to dissolution and functionalization, and their further modifications including glycosylation. This review highlights the application of RTILs that have been extensively used in carbohydrate chemistry.
    Current Organic Synthesis 09/2010; 7(5):506-531. DOI:10.2174/157017910792246063 · 2.44 Impact Factor
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    ABSTRACT: There is an increased demand for significant amounts of carbohydrate based molecules for complete biological, medicinal, and pharmacological investigations where tremendous efforts have been made to develop novel and facile procedure for the synthesis of glycoconjugates and diverse carboxamides. Limitations with the common approaches for amide bond formation, including use of hazardous chemicals, long reaction times, low reaction yields, frequently require strong basic catalysts, strictly anhydrous conditions, harsh reaction conditions, expensive and limited availability of coupling materials, and moreover the less stability of activated acids warrant the search of a simple, short, and high yielding amide bond synthetic methodology. Herein, a facile and high yielding synthesis of novel glycosyl carboxamide with both furanose and pyranose sugar using benzotriazole methodology has been developed under mild conditions.
    Letters in Organic Chemistry 02/2010; 7(2):136-143. DOI:10.2174/157017810790796363 · 0.65 Impact Factor
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    ABSTRACT: Leishmaniasis, a vector-borne parasitic disease resulting from infection of macrophages by obligate intracellular parasites of genus Leishmania, has been considered a major tropical disease by the World Health Organization. Generic pentavalent antimonials have been the mainstay for therapy in the endemic regions because of its efficacy and cost effectiveness. However, the growing incidence of resistance for the pentavalent antimony complex in endemic and non-endemic regions has seriously hampered their use in these regions. The second line drugs such as amphotericin B, paromomycin and miltefosine are the other alternatives, but they merely fulfill the desired requirements of a safe drug. The recent researches focused on plants have shown a wise way to get a true and potentially rich source of drug candidates against leishmaniasis, where alkaloids have been found more effective. The present review initially highlights the current status of leishmaniasis, synergy of the disease with HIV, therapeutic options available and in later sections summarizes all alkaloids, which have shown significant antileishmanial activities.
    Fitoterapia 11/2008; 80(2):81-90. DOI:10.1016/j.fitote.2008.10.009 · 2.22 Impact Factor